What is pathophysiology of Diabetes?

['Engkalingai iyaé bagiyangngé']

Aga fisiopatologi pole ri diabetes?

Pathophysiology of diabetes iyanaritu aggurung proses fisiologis iya de'na taratur iya nassabari pallebangenna diabetes mellitus.

Diabetes mellitus iyanaritu kelompo' lasa metabolisme iya ritanrai pole kadar gula darah (glukosa) matanre iya wassele pole defek ri laleng sekresi insulin, aksi insulin, iyarega keduwa e.

Fisiologi pato diabetes muttama interaksi kompleks faktor genetik, lingkungan, nenniya gaya atuongeng iya mabbantu lao pallebangeng lasa e.

Ri laleng tipe 1 diabetes, patofisiologi muttama'i ancurukeng autoimun sel beta iya makkewassele insulin ri pankreas, nassabari kurangna produksi insulin.

Iyyae nassabari de'na ullei natoro tingka' glukosa dara, nassabari hiperglikemia (gula dara matanre).

Ri lalenna tipe 2 diabetes, patofisiologi lebbi kompleks nenniya naputtama'i keduwa resistensi insulin nenniya gangguan sekresi insulin.

Resistensi insulin kajajiang narekko selna watakkalena de'na natarimai insulin sibawa makessing, nassabari de'na ullei makkeguna glukosa untu' energi.

Iyae nassabari pankreas makkebbu lebbi maega insulin untu' nacoba nacau resistensi, naekiya ri wettu labe'e, pankreas nulle de naullei napertahankang sibawa apparelluang, nassabari makurang produksi insulin.

Gesta diabetes, iya kajajiang sipungenna mattampu, ripancaji pole perubahan hormonal iya nassabari resistensi insulin.

Placenta makkebu hormon iya weddingnge nasolang akkegunang insulin, nassabari menre tingka' glukosa dara.

Pathophysiology diabetes to naputtama'i allebbangeng komplikasi, pappada ancurukeng lao ri pembuluh dara, saraf, nenniya organ, iya wedding nassabari masalah kesehatan iya matane'e pappada lasa ati, stroke, lasa ginjal, nenniya ateddengeng pakkitang.

Mappahang patofisiologi diabetes parellu ladde untu' pallebang pabbura nenniya strategi pencegahan iya efektif untu' lasa iyae mallamung e.

['Rilaleng']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

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What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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