What causes Alzheimer?

['Piŋë në ye athöörë yic']

Yeŋo ye alzheimer bɛ̈ɛ̈i?

Tuany de Alzheimer ee tuany ye tɔ̈ ke ye tuany de neurodegenerative disorder ye nhom riɔ̈ɔ̈k apɛi, man ye nhom määr, ku ye nhom riɔ̈ɔ̈k apɛi, ku ye aciëëk bɛ̈n waar.

Kë ye tuaany de Alzheimer bɛ̈i acïï nyic apuɔth, ku ka ye gam ke ye rot looi në kë de kä ye röt määt yiic, kä ye röt looi në ɣän kɔ̈k yiic, ku jɔl ya tɛ̈n yenë raan pïïr thïn.

Kä kɔ̈k lëu bïk tuany de Alzheimer ya juakic anɔŋic:

1. Genetics: Genes kɔ̈k acï kek ya ŋic ëke ye tuany de Alzheimer juakic, ku ye tuany kënë ee tuany de apolipoprotein E (APOE) gene.

2. Run: Kë ye yök ke tuany de Alzheimer ee rot juak apɛi ke run lɔ tueŋ, ku kɔc juëc aye tuany de yök të nɔŋ run 65.

3. Akököl de baai: Na nɔŋ raan de baai cï tuaany de Alzheimer dɔm, ke ka lëu bï tuanydu juak.

4. Tɔŋ nhom: Tɔŋ nhom cï lac yök, cï man de kä ye raan cɔk mär nhom, alëu bï tuany de Alzheimer juak.

5. Riɛ̈m de cuäŋ: Riɛ̈m cïtmɛn de cuäŋ ë riɛm, cholesterol, ku tuany de cuäŋ alëu bï tuany de Alzheimer juakic.

6. Kä ye raan ke looi: Të yenë raan rëër ke cïn kë ye looi, mïïth ye cam, ku jɔl ya tɛ̈n cïï nhom de raan rot lac lui apath, alëu bï tuany de Alzheimer juak yic.

7. Gɛ̈ɛ̈r: Gɛ̈ɛ̈r ë nhom de raan alëu bï tuany de Alzheimer bɛ̈i.

8. Rɛ̈ɛ̈c de kä ye cɔla oxidative: Të cïï kä ye cɔla free radicals röt ye looi ku jɔl ya riɛl de guɔ̈p de kä rɛc ke yiic, alëu bï tuany de Alzheimer ya cɔk loi rot.

9. Amyloid plaques ku jɔl ya neurofibrillary tangles: Käjuäc cï kek ya tɔ̈ɔ̈u në nhom yic aye lac nyic në tuany de Alzheimer, ku ka cïï kek ye deet apath në kë ye kek tuany kënë bɛ̈i.

Kë thiekic ba nyic ee lɔnadɛ̈ ke kë ye tuaany de Alzheimer looi ee kë rilic apɛi ku ka nɔŋ kä juëc ye kek mat thïn.

Rïthäc aye looi në yemɛɛn agonë kä tɔ̈ thïn ya deet ku bï kä ye tuaany kän ya kony ya cak.

['Kä cï gɔ̈ɔ̈r']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

['Wɛ̈t cï lueel: wal']

['Wɛbthait kën ee piööc ku wël tɔ̈u thïn ku acie kë ye looi bï kɔc ke akïm ya lɛ̈k wala bï kɔc ke luɔi ya kony.']

['Wël cï kek ya lueel në ye athöör kënë yic acïï lëu bï kek ya kony agonë tuanytuɛny ya ŋic ku bï kek ya kony, ku kɔc wïc kuɔɔny de akïm adhil akïm de akïm ya thiëëc bï kek ya kony.']

['Tiɛ̈ŋë kä ye kuɔɔny de neural net looi, man ye kä ye bɛ̈n në kä cï kek ya thiëëc yiic, aye kek cɔk tɔ̈ ëke cïï kek ye deet yiic në thɛɛr juëc yiic. Cïmën de, ciin de kɔc cï kek yök ëke tuany.']

['Thïëc wɛ̈t akïmdu ka raan dɛ̈t wënë cï piöc ë pialgup wënë cï yök në biäk de tuaany. Duk wɛ̈t akïm ye kuɛ̈ɛ̈c nhom cɔk alɔn cï yen ya kë cï kueen në wɛbthait kënnë yic. Na ye tak ke yïn nɔŋ kë wïc bë yï kony në tuany, cɔl 911 ka lɔɔr në ɣön akïm tɔ̈u të thiääk ke yï në kaam thiin koor yic. Acïn akïm-tuany ye thiääk në yen në wɛbthait kënnë yic ka luɔ̈i de. BioMedLib ka kɔc cï luöi, ka raan ëbɛ̈n ye luui në yen në wɛbthait kënnë yic, acïn kë ye lueel, ye lueel ka ye lueel, në kë de wël cï kek gɔ̈ɔ̈r në ye athöör kënnë yic ka luɔ̈i de.']

['Wɛ̈t cï lueel: copyright']

['Lööŋ ke Digital Millennium Copyright Act de 1998, 17 U.S.C. § 512 (ye DMCA) ee kɔc ye käke kɔc gɔ̈t gam ke kä tɔ̈ në Internet aye käken tɔ̈ në U.S. copyright law dhoŋ kɔ̈th. ']

['Na ye gam në yith ke këriɛ̈ɛ̈c ka kä cï gɔ̈ɔ̈r tɔ̈ në wɛbthaitda ka kuɔɔnyda yic acï löŋ de gël de kä cï gɔ̈ɔ̈r dhoŋ kɔ̈u, ke yïn (ka raan ye yïn luɔ̈ɔ̈i) alëu ba ɣok tuɔ̈c wɛ̈t bï këriɛ̈ɛ̈c ka kä cï gɔ̈ɔ̈r nyaai, ka bï yïn pëën ba lɔ thïn. ']

["Wël aa bë ke tuɔɔc në athöör yic në email (tïŋ 'Rin de athöör' në biäk de email)."]

['DMCA ee wïc lɔnadɛ̈ ke kë ca lueel de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i anɔŋic wël cï keek gɔ̈ɔ̈r: (1) luɛɛl de kä cï keek luɔ̈ɔ̈i cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i cï keek lueel; (2) luɛɛl de kä cï keek gɔ̈ɔ̈r cï keek lueel ku wël cï keek lueel bï keek cɔk lëu bïkë kä cï keek gɔ̈ɔ̈r yök; (3) wël bï yïn ke kɔn ya kɔɔr, nɔŋiic adrɛ̈ɛ̈rdu, namba de telepun ku adrɛ̈ɛ̈r de imeel; (4) wɛ̈t cï lueel në yï nhom lɔnadɛ̈ ke yïn ye gam ke kë cï gɔ̈ɔ̈r cï looi në kueer cï yïn ye gaam acie gam në raan de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i, ka raan de lööŋ, ka në luɔɔi de löŋ; ']

['(5) athöör cï yïn gätpiny në awuɔ̈c de wɛ̈t lueth, lɔnadɛ̈ ke wël tɔ̈ në athöör yic aye yith ku lɔnadɛ̈ ke yïn anɔŋ riɛl ba kä cï gɔ̈t ke lööŋ ke raan nɔŋ nhïïm ya looi në kë cï wuɔ̈ɔ̈c; ']

['Ku (6) ke ye kä cï gɔ̈t ke guɔ̈p ka kä cï gɔ̈t ke mɛ̈ɛ̈t de raan de kä cï luɔ̈ɔ̈i ka raan cï gäm riɛl bï luui në nyin de raan de kä cï luɔ̈ɔ̈i. ']

['Na këc wël cï gɔ̈ɔ̈r nhial tɔ̈u thïn kedhiɛ gɔ̈t, ke ka lëu bï këdun cï yïn gaam ya gääu.']

['Thiëc kek']

['Tuɔɔc email tënë ɣok na nɔŋ këdun thiëc/cï yïn tak.']

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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