Urticaria, man ye lac ŋic ke ye tuany de cuäŋ, aye nyuɔɔth ke nɔŋ kë ye raan ŋuɛ̈ɛ̈n, ye rot jat nhial, ku ye kɔ̈u thiäŋ në miök.
Kä ye tuany cɔl urticaria bɛ̈i aye histamine ku jɔl ya kä kɔ̈k ye tuany cɔl inflammatory mediators bɛ̈i bei në mast cells yiic, man ye kek cɔl kek immune cells ye tɔ̈ në guɔ̈p yic ku jɔl ya guɔ̈p kɔ̈k peei yiic.
Në tuany de urticaria yic, ke histamine ku jɔl ya kä kɔ̈k peei ye kek liääp aye kek bɛ̈n ya liääp në kë de tuany de cuäŋ, cïmën de mïïth, wal, ka käm ye kek cuäŋ.
Kän ee cells ke mast cɔk liääp, ku bïk histamine ku jɔl ya kä kɔ̈k peei ye riɛm ya liääp bɛ̈i ku bïk ya liääp.
Në tuany de urticaria, ke kë ye yen bɛ̈i acïï nyic, ku ka ye tak ke ye tuany de autoimmune.
Në ye mɛn ke guɔ̈p ee autoantibodies looi man ye high-affinity IgE receptor (FcεRI) në mast cells, man ye kek cɔk lui ku bïk histamine ku jɔl ya kä kɔ̈k peei ya cɔk loi röt ya cɔk loi röt.
Në tuanytuɛnytuɛɛny ke adheŋ ku jɔl ya tuanytuɛɛny ke gup, ke histamine ku jɔl ya kä kɔ̈k peei ye kek liääp aye kä ye kɔc nyuɔ̈th adheŋ ë nyin bɛ̈i, ku bï kek ya ŋuɛ̈ɛ̈n ku bï kek ya ŋuɛ̈ɛ̈n.
Wal aye yen mat thïn ëbën agut cï wal ye histamine gël ku bïk kä ye yen nyuɔɔth cɔk liääp.
Në tuany rac apɛi, ke wal kɔ̈k cït corticosteroids ka omalizumab alëu bï kek ya looi ago tuanytuɛɛny ya mac.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
['Wɛ̈t cï lueel: wal']
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['(5) athöör cï yïn gätpiny në awuɔ̈c de wɛ̈t lueth, lɔnadɛ̈ ke wël tɔ̈ në athöör yic aye yith ku lɔnadɛ̈ ke yïn anɔŋ riɛl ba kä cï gɔ̈t ke lööŋ ke raan nɔŋ nhïïm ya looi në kë cï wuɔ̈ɔ̈c; ']
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What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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