What is pathophysiology of Breast cancer?

['Tega amatwi iyi paji']

Ni iyihe mikorere y'umubiri w'indwara ya kanseri y'ibere?

Imikorere y'umubiri w'indwara ya kanseri y'ibere yerekeza ku mpinduka zidasanzwe mu mikorere isanzwe n'imikorere y'umubiri ibaho mu mikurire n'iterambere bya kanseri y'ibere.

Harimo kwiga uburyo kamere n'imikorere y'uturemangingo dutera kanseri yo mu mabere gukura no gukwirakwira mu buryo butagira rutangira.

Ibi birimo imiterere y'uturemangingo dutera kanseri, imiterere y'uturemangingo dutera kanseri n'ibidukikije bigira uruhare mu gutangira, guteza imbere no gukwirakwiza kanseri y'ibere.

Zimwe mu mpinduka z'ingenzi mu mikorere y'umubiri w'indwara mu kanseri y'ibere harimo:

1. Impinduka mu ngirabuzima fatizo: Impinduka mu ngirabuzima fatizo zimwe na zimwe, urugero nka BRCA1 na BRCA2, zishobora gutuma umuntu arwara kanseri y'ibere.

Izo mpinduka zishobora guturuka ku murage umuntu aba yarazwe cyangwa zikamubamo mu gihe cy'ubuzima bwe.

2.Kudashyira mu gaciro kw'imisemburo: imisemburo, cyane cyane estrogen, ishobora kugira uruhare mu ikura n'ikwirakwira rya kanseri y'ibere.

Iyo imisemburo y'abagore idahwanye cyangwa se iyo hari imisemburo myinshi cyane, bishobora gutuma barwara kanseri y'ibere.

3. Kuribwa: Kuribwa mu gatuza igihe kirekire bishobora gutuma habaho kanseri y'ibere, kuko bituma ingirabuzimafatizo ziyirimo zikura kandi zigakomeza kubaho.

4. Aho kanseri y'ibere iba: Aho kanseri y'ibere iba, harimo uturemangingo two hanze yayo, uturemangingo turinda umubiri ndetse n'imitsi, bishobora gutuma ikura kandi igakwirakwira.

5. Gukura: Kanseri y'ibere ishobora gukwirakwira mu bindi bice by'umubiri binyuze mu maraso, bigatuma habaho ibindi bibyimba mu bindi bice by'umubiri.

Gusobanukirwa imiterere ya kanseri y'ibere ni ingenzi mu rwego rwo kwirinda, gutahura hakiri kare no kuvura neza.

['Ibitabo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.

Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.

Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.

Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.

Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.

['Icyitonderwa: ubuvuzi']

["Uru rubuga rwashyiriweho kwigisha abantu no kubaha amakuru gusa, ntirutanga inama ku birebana n'ubuvuzi cyangwa ngo rukore nk'ikigo gitanga serivisi z'ubuvuzi."]

["Amakuru atangwa n'iyi porogaramu ntagomba gukoreshwa mu gusuzuma cyangwa kuvura ikibazo cy'uburwayi cyangwa indwara runaka, kandi abashaka inama z'ubuvuzi bagombye kugisha inama umuganga ubifitiye uburenganzira."]

['Nyamuneka menya ko imbuga nkoranyambaga zitanga ibisubizo kubibazo, ntabwo zifite ukuri mugihe kijyanye numubare. Kurugero, umubare wabantu basanzwemo indwara runaka.']

["Buri gihe ujye usaba inama umuganga wawe cyangwa undi muntu wemewe mu bijyanye n'ubuzima ku bijyanye n'uburwayi. Ntuzigere wirengagiza inama z'abaganga cyangwa ngo utinde kuzisaba bitewe n'ikintu wasomye kuri uru rubuga. Niba utekereza ko ufite ikibazo cyihutirwa, hamagara 911 cyangwa ujye ku ivuriro rikwegereye. Nta mubano hagati y'umuganga n'umurwayi ukorwa n'uru rubuga cyangwa ikoreshwa ryarwo. Yaba BioMedLib cyangwa abakozi bayo, cyangwa undi muntu wese wagize uruhare kuri uru rubuga, nta gihamya batanga, yaba igaragara cyangwa itagaragara, ku bijyanye n'amakuru atangwa hano cyangwa ikoreshwa ryayo."]

["Ibirego: uburenganzira bw'umuhanzi"]

["Itegeko ryo mu 1998 ryerekeye uburenganzira bw'ibihumbi by'ibihumbi by'ibihumbi by'ibihumbi, 17 U.S.C. § 512 (DMCA) ritanga ubujurire ku bafite uburenganzira bw'umuhanzi bemera ko ibintu bigaragara kuri interineti bibangamira uburenganzira bwabo hakurikijwe amategeko y'uburenganzira bw'umuhanzi muri Amerika. "]

['Niba wemera ko ibintu cyangwa ibikoresho byashyizwe ku rubuga rwacu cyangwa serivisi bitubahiriza uburenganzira bwawe, wowe (cyangwa umuhagarariye) ushobora kutwoherereza ubutumwa udusaba ko ibyo bintu cyangwa ibikoresho bikurwaho, cyangwa ko utabikoresha.']

['Itangazo rigomba koherezwa mu nyandiko kuri interineti (reba ahanditse "Kwitaba" kugira ngo ubone aderesi ya interineti). ']

["DMCA isaba ko imenyesha ryawe ry'ikirego cyo kuvutswa uburenganzira rikubiyemo amakuru akurikira: (1) ibisobanuro by'igikorwa kirengera uburenganzira bw'umuhanzi kivugwaho kuvutswa uburenganzira; (2) ibisobanuro by'ibikubiyemo bivugwa ko ari ukurenga ku mategeko n'amakuru ahagije atuma dushobora kubona ibikubiyemo; (3) amakuru yo kuguhamagaraho, harimo aderesi yawe, nomero ya terefone na aderesi imeyiri; (4) inyandiko yawe ivuga ko ufite icyizere ko ibikubiyemo mu buryo bwatanzwe nta burenganzira bifite na nyiri uburenganzira bw'umuhanzi, cyangwa umukozi we, cyangwa mu mategeko ayo ari yo yose; "]

["(5) inyandiko yawe isinyweho, uhanishwa kubeshya, yemeza ko amakuru ari mu itangazo ari ukuri kandi ko ufite ububasha bwo kurengera uburenganzira bw'umuhanzi uvugwaho kubwamburwa; "]

["kandi (6) umukono usanzwe cyangwa wa elegitoroniki w'ufite uburenganzira ku nyandiko cyangwa uw'umuntu wabiherewe uburenganzira bwo gukora mu izina ry'ufite uburenganzira ku nyandiko. "]

['Kudatanga amakuru yose yavuzwe haruguru bishobora gutuma ikibazo cyawe gitinda gukemurwa.']

['Uko twavugana na we']

['Ohereza imeri ikibazo / igitekerezo.']

What is pathophysiology of breast cancer?

Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.

It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.

This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.

Some of the key pathophysiological changes in breast cancer include:

1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.

These mutations can be inherited or acquired during a person's lifetime.

2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.

An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.

3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.

4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.

5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.

Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.

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