Muanda wa disama dia muoyo (anyi infarctus du myocarde) udi utangila dinyanguka dia mashi adi aya ku tshitupa tshia mufuba wa muoyo, ne udi ufikisha ku lufu lua selile ya mu muoyo.
Batu batamba kuenzela bualu ebu padi disama dia mu mashi disanga mu mijilu ya mu mashi, ne misangu ya bungi disama edi ditu difumina ku disama dia atherosclerose, disama didi dienza bua ne: mashi a bungi adishangishe mu mijilu ya mu mashi.
Tshintu etshi tshidi tshienza ne kolestrol, mafuta, bintu bidi mu selile, calcium ne fibrine.
Padi disama edi dibola, didi mua kuenza bua mashi a disama adibu babikila ne: caillot a mu mutshima adishinde, ne kupangisha mashi adi ne oksijene bua kafikidi ku muoyo.
Dipangila dia kapepe aka didi difikisha selile ya mu mubidi wa muoyo ku difua, ne difikisha ku disama dia muoyo.
Bujitu bua njiwu budi bulonda bunene bua muaba udi disama edi dienzeka ne bungi bua matuku adi pankatshi pa disama ne diondopibua.
Bimanyinu bia disama dia muoyo bidi mua kuikala bisama mu tshiadi, mupuya mukole, disama dia mu mutu, dibungama, ne bisama mu maboko, mu nshingu, mu matama anyi mu nyima.
Pa tshibidilu, buanga bua disama dia muoyo butu buambuluisha bua mashi kupinganawu mu mubidi wa muoyo ne lukasa luonso, ku diambuluisha dia manga anyi dia ngondapilu bu mudi angioplasty ne dibueja dia dibue dia mu nshingu anyi dia dibueja dia mashi mu nshingu.
Bidi ne mushinga bua kumanya ne: disama dia muoyo ditu ne malu a bungi adi aditungunukila, bu mudi dia mu mashi, dia mu nsombelu ne dia muaba utudi basombele.
Bimue bintu bidi mua kukebesha disama dia muoyo mbashipa mashi, disama dia mu mubidi, dinua dia makanya, disama dia diabete, dibanda dia mubidi, dibenga kuibidija mubidi ne kuikala ne disama dia muoyo mu dîku.
Kuikala ne meji mimpe bua malu aa kudi mua kukepesha njiwu ya kupeta disama dia muoyo.
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Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .
Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.
LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.
Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.
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['Dibenga kuambula bujitu: bua malu a luondapu']
['Site eu udi ne tshipatshila tshia kulongesha ne kumanyisha patupu, ki ntshia kufila mibelu ya manga anyi midimu ya baminganga to.']
['Malu adibu bafile aa kaena ne bua kuambuluisha bua kumanya disama kampanda anyi bua kudiondopa to, ne bantu badi bakeba mibelu ya malu a luondapu badi ne bua kuyikila ne munganga udi ne mukanda wa dianyisha dia mudimu.']
['Tangila ne: ordinatere udi ufila mandamuna a nkonko eyi utu utamba kupanga kujadika malu padiwu ne malu a bungi bu mudi bungi bua bantu badibu bakuate ne disama kampanda.']
['Ikala misangu yonso ukeba mibelu ya munganga anyi ya munganga mukuabu udi mumanye bimpe malu a luondapu. Kupepeji mibelu ya baminganga anyi kuanji kuanji kuindila bua kuyikeba anu bua bualu kampanda buudi mubale mu site eu to. Wewe wela meji ne: udi ne disama dia lukasa, fubidila 911 anyi ndaku diakamue ku lupitadi lua pabuipi nebe. Site eu anyi dienza mudimu nende ki mbienze bua kuikale malanda pankatshi pa munganga ne mubedi to.']
['Mikenji ya mu États-Unis idi ilomba bantu badi ne bukenji bua kuenza bintu kampanda bua kuenzabu malu makuabu.']
['Wewe mumone ne: bualu kampanda budi mu site wetu anyi mu midimu yetu budi bunyanga manême ebe a bintu, udi mua kututumina mukanda bua kutulomba bua kubujikija anyi kubupangisha bua kububala.']
['Badi ne bua kutuma dimanyisha edi mu mukanda ku Enternete (bala tshiena-bualu tshia "Contact" bua kupeta adrese wa Enternete). ']
['DMCA udi ulomba ne: mu dimanyisha diebe dia bualu budibu bamba ne: mbupangile bukenji bua kufundilangana malu mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu 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mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda 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mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik 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mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik 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mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik']
['5) mukanda uudi wewe muine mufunde udi uleja ne: malu adi mu mukanda eu mmalelela ne udi ne bukokeshi bua kuenzeja bukenji budibu bamba ne: mbunyange.']
['ne 6) tshiala tshia muena bukenji anyi tshia muntu udi ne bukokeshi bua kuenza malu mu dîna dia muena bukenji. ']
['Nudi mua kututumina mesaje a ku Enternete ne lukonko anyi lungenyi luenu luonso.']
What is pathophysiology of heart attack?
The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.
This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.
The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.
When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.
This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.
The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.
Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.
Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.
It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.
Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.
Managing these risk factors can help reduce the likelihood of experiencing a heart attack.
Disclaimer: medical
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