What is pathophysiology of Lung cancer?

Ntshinyi tshidi tshienza bua kansere ka bisulusulu kulela?

Muaku patophysiologie udi umvuija dishintuluka dia malu adi enzeka mu mubidi ne mushindu udiwu wenda padi kansere ka bisulusulu kenda kavula.

Kansere ka bisulusulu nkasama ka bungi kadi kafumina ku didiunda ne ditapuluka dia selile idi kayiyi mienza bimpe mu bisulusulu.

Tuishi etu tudi mua kuenza tumue tumue ne kualabalaka mu bitupa bikuabu bia mubidi, tufikisha ku bimanyinu ne ntatu mishilashilangane.

Muanda wa kansere ka bisulusulu udi ne malu a bungi bu mudi: dishintuluka dia bintu bia mu selile, malu a mu nsombelu ne nsombelu wa muntu.

Dishintuluka dia mu selile didi mua kuenzeka mu selile ya bisulusulu, difikisha ku didiunda dia selile ne ditapuluka dia selile.

Dishintuluka dia mushindu eu dia mubidi didi mua kuikala dia ku tshilelelu anyi dia muntu udi mudilengeje, ne didi mua kuikala difumine ku bintu bidi bikuata kansere bu mudi muishi wa makanya, radon, amiante ne dinyanguka dia kapepe.

Kansere ka bisulusulu idi mua kuikala ya mishindu ibidi: kansere ka bisulusulu bikese (SCLC) ne kansere ka bisulusulu bikese (NSCLC).

Disama dia kansere ka bisulusulu edi didi mua kuikala dishilangane bualu didi ne tutupa tukuabu tua mu selile ne ditu diandamuna mushindu mukuabu ku luondapu.

Mu malu a kansere ka bisulusulu mudi kabidi dipetangana pankatshi pa selile ya kansere ne bisulusulu bidi bimunyunguluke, kusangisha ne bia mubidi.

Tuishi tua kansere tutu tupangila mubidi bua kutupangisha bua kuluangana ne masama, tulekelayi yenda yenda yenda ivula ne yenda yenda yenda yenda yenda yenda yenda yenda.

Kabidi, tumue tutupa tudi tuenza bua kansere katuadije kudiunda tudi mua kukuatshisha kabidi bua katuadije kuvula.

Malu a disama dia kansere ka bisulusulu mmakole ne adi enda aya kumpala, ne bakebuludi badi benza mudimu bikole bua kumvua bimpe malu adi enzeka bua kupeta ngondapilu muimpe ne kuondopa babedi bimpe.

['Malu adibu bafunde']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.

Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.

Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.

Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .

Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .

Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.

['Dibenga kuambula bujitu: bua malu a luondapu']

['Site eu udi ne tshipatshila tshia kulongesha ne kumanyisha patupu, ki ntshia kufila mibelu ya manga anyi midimu ya baminganga to.']

['Malu adibu bafile aa kaena ne bua kuambuluisha bua kumanya disama kampanda anyi bua kudiondopa to, ne bantu badi bakeba mibelu ya malu a luondapu badi ne bua kuyikila ne munganga udi ne mukanda wa dianyisha dia mudimu.']

['Tangila ne: ordinatere udi ufila mandamuna a nkonko eyi utu utamba kupanga kujadika malu padiwu ne malu a bungi bu mudi bungi bua bantu badibu bakuate ne disama kampanda.']

['Ikala misangu yonso ukeba mibelu ya munganga anyi ya munganga mukuabu udi mumanye bimpe malu a luondapu. Kupepeji mibelu ya baminganga anyi kuanji kuanji kuindila bua kuyikeba anu bua bualu kampanda buudi mubale mu site eu to. Wewe wela meji ne: udi ne disama dia lukasa, fubidila 911 anyi ndaku diakamue ku lupitadi lua pabuipi nebe. Site eu anyi dienza mudimu nende ki mbienze bua kuikale malanda pankatshi pa munganga ne mubedi to.']

['Dibenga kutumikila mikenji: bukenji bua kufunda']

['Mikenji ya mu États-Unis idi ilomba bantu badi ne bukenji bua kuenza bintu kampanda bua kuenzabu malu makuabu.']

['Wewe mumone ne: bualu kampanda budi mu site wetu anyi mu midimu yetu budi bunyanga manême ebe a bintu, udi mua kututumina mukanda bua kutulomba bua kubujikija anyi kubupangisha bua kububala.']

['Badi ne bua kutuma dimanyisha edi mu mukanda ku Enternete (bala tshiena-bualu tshia "Contact" bua kupeta adrese wa Enternete). ']

['DMCA udi ulomba ne: mu dimanyisha diebe dia bualu budibu bamba ne: mbupangile bukenji bua kufundilangana malu mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mufunda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mikanda mu mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik mik']

['5) mukanda uudi wewe muine mufunde udi uleja ne: malu adi mu mukanda eu mmalelela ne udi ne bukokeshi bua kuenzeja bukenji budibu bamba ne: mbunyange.']

['ne 6) tshiala tshia muena bukenji anyi tshia muntu udi ne bukokeshi bua kuenza malu mu dîna dia muena bukenji. ']

['Wewe kuyi mufunde malu onso aa, udi mua kuladikija tshilumbu tshiebe.']

['Diyukidilangana']

['Nudi mua kututumina mesaje a ku Enternete ne lukonko anyi lungenyi luenu luonso.']

What is pathophysiology of lung cancer?

The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.

Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.

These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.

The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.

Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.

Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.

The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.

Cancer cells can evade the immune system, allowing them to grow and spread unchecked.

Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.

The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.

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