How is Alzheimer diagnosed?

Wuliriza olupapula luno

Obulwadde bwa alzheimer buzuulibwa butya?

Obulwadde bwa Alzheimer buzuulibwa okuyita mu nkola ez'enjawulo, nga mw'otwalidde n'okunoonyereza okw'amaanyi okw'ekisawo, ebigezo eby'okutegeera n'eby'obwongo, okukuba ebifaananyi by'obwongo, n'okusalawo ku bintu ebirala ebiyinza okuleetawo obulwadde buno.

1. Okukeberebwa abasawo: Omusawo ajja kukeberebwa era n'atwala ebyafaayo by'obulamu bw'omuntu okusobola okumanya obanga waliwo ebintu ebirala ebiyinza okuleetera omuntu okufiirwa ekijjukizo oba obutegeera, gamba ng'obulwadde bw'ekibumba, obutaba na bitamiini, oba obwongo.

2. Ebigezo by'okutegeera n'eby'obwongo: Ebigezo bino bikebera okujjukira, olulimi, okugonjoola ebizibu, n'emirimu emirala egy'okutegeera okusobola okumanya obunene bw'obunafu bw'okutegeera n'okusalawo wakati w'okufiirwa okujjukira okw'omulembe n'obulwadde bw'obwongo.

3. Okukebera obwongo: Okukebera obwongo nga bakozesa magnetic resonance imaging (MRI) oba computed tomography (CT) kisobola okukuyamba okumanya enkyukakyuka eziri mu bwongo eziyinza okulaga obulwadde bwa Alzheimer.

Positron emission tomography (PET) esobola n'okukozesebwa okupima omutindo gw'ebirungo ebimu ebikwatagana n'obulwadde bwa Alzheimer.

4. Ebigezo by'omusaayi: Okunoonyereza okwakolebwa gye buvuddeko awo kulaga nti ebigezo by'omusaayi ebimu bisobola okuyamba okuzuula obulwadde bwa Alzheimer nga bikebera omutindo gw'ebijanjaalo oba biomarker ezikwata ku bulwadde buno.

5. Enkola y'okuggyawo endwadde: Okuva bwe kiri nti tewali nkola emu ey'okunoonyereza ku bulwadde bwa Alzheimer, oluusi kyetaagisa okuggyako ensonga endala eziyinza okuleetawo obubonero obw'obulwadde obw'obulwadde bw'obwongo.

Kikulu okukijjukira nti obulwadde bwa Alzheimer busobola okuzuulibwa oluvannyuma lw'okufa okuyita mu kukebera obwongo bw'omuntu.

Kyokka, enkola z'okunoonyereza ez'omu kiseera kino zisobola okuwa obukakafu obw'amaanyi ku bulwadde bw'omuntu ng'akyali mulamu.

Okuzuula obulwadde mu bwangu kikulu nnyo okusobola okutandika okufuna obujjanjabi n'okuteekateeka eby'omu maaso.

Ebikwata ku bantu

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

Okwewala obuvunaanyizibwa: eby'obujjanjabi

Omukutu guno guweereddwa olw'ebigendererwa by'enjigiriza n'obubaka bwokka era teguwa kubuulirira kw'ekisawo oba obuweereza bw'ekikugu.

Obubaka obuweereddwa tebusaanidde kukozesebwa okuzuula oba okujjanjaba bulwadde, era abo abanoonya amagezi g'ekisawo balina okwebuuza ku musawo alina layisensi.

Weetegereze nti enkola ya neural net ekola eby'okuddamu mu bibuuzo, si ntuufu nnyo bwe kituuka ku muwendo gw'abantu. Ng'ekyokulabirako, omuwendo gw'abantu abalwadde obulwadde obumu.

Bulijjo noonya amagezi g'omusawo wo oba omusawo omulala omutuufu ku bikwata ku mbeera y'obulamu. Teweerabira magezi g'omusawo oba okulwawo okuganoonya olw'ekintu ky'osomye ku mukutu guno. Bw'oba olowooza oyinza okuba n'embeera ey'amangu mu by'obulamu, yita 911 oba genda mu ddwaaliro ly'amangu erisinga okumpi amangu ddala. Tewali nkolagana ya musawo n'omulwadde ekolebwa ku mukutu guno oba okukozesawo. BioMedLib oba abakozi baagwo, oba omuntu yenna ayamba ku mukutu guno, talina ky'agamba, ekyogamba oba ekiteeberezebwa, ku bikwata ku bubaka obuli wano oba okukozesawo.

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Okuwuliziganya

Tukusaba otutumire e-mail n'ebibuuzo / amagezi.

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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