Ensonga entuufu eziviirako kookolo wa prostate tezitegeerekeka bulungi, naye waliwo ebintu ebiwerako ebimanyiddwa ebyongera ku bulabe bw'okufuna obulwadde buno.
Mu bino mwe muli emyaka, ebyafaayo by'amaka, ekika, n'enkyukakyuka ezimu ez'ekinnansi.
Obulwadde bw'akawuka ka prostate businga kubaawo mu basajja abakaddiye, ng'abasinga kulabika mu basajja ab'emyaka egisukka mu 65.
Okugatta ku ekyo, abasajja abalina obulwadde bwa kookolo mu maka gaabwe bali mu kabi ak'amaanyi, nga n'abasajja Abazungu Abamerika n'abasajja ab'omu Caribbean bwe bali.
Obulwadde bwa kookolo wa prostate buzingiramu okukula n'okwawukana kw'obutoffaali mu prostate gland.
Kino kiyinza okubaawo olw'enkyukakyuka z'ensolo ezireetawo okweyongerayongera kw'ebintu ebimu ebireeta okukula oba okulemererwa kw'ensolo ezirwanyisa obulwadde bw'ekibumba.
Mu mbeera ezimu, obutoffaali bw'akawuka busobola okuva ku bulwadde obusookerwako ne busasaana mu bitundu ebirala eby'omubiri okuyita mu musaayi oba mu lymphatic system, enkola eyitibwa metastasis.
Kansa ya prostate era eyinza okukosebwa ebintu eby'ekika kya hormone, naddala testosterone ey'ekika kya androgen.
Testosterone esobola okukubiriza okukula kw'obutoffaali bw'akawuka ka prostate, era obujjanjabi bungi obw'akawuka ka prostate bulina ekigendererwa eky'okukendeeza ku mutindo gwa hormone eno oba okuziyiza ebivaamu.
Mu bufunze, obulwadde bwa kookolo wa prostate buzingiramu okukula n'okugabanyizibwamu kw'obutoffaali mu prostate gland, obusobola okukosebwa ebintu eby'ekika ky'ekika, eby'ekika ky'ekika ky'ekika ky'ekika, n'eby'obutonde.
Okutegeera enkola y'obulwadde buno kikulu nnyo mu kukulaakulanya obujjanjabi obw'omugaso n'okulongoosa ebivuddemu eri abalwadde b'obulwadde bwa kkansa ya prostate.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
Okwewala obuvunaanyizibwa: eby'obujjanjabi
Omukutu guno guweereddwa olw'ebigendererwa by'enjigiriza n'obubaka bwokka era teguwa kubuulirira kw'ekisawo oba obuweereza bw'ekikugu.
Obubaka obuweereddwa tebusaanidde kukozesebwa okuzuula oba okujjanjaba bulwadde, era abo abanoonya amagezi g'ekisawo balina okwebuuza ku musawo alina layisensi.
Weetegereze nti enkola ya neural net ekola eby'okuddamu mu bibuuzo, si ntuufu nnyo bwe kituuka ku muwendo gw'abantu. Ng'ekyokulabirako, omuwendo gw'abantu abalwadde obulwadde obumu.
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The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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