How is Alzheimer diagnosed?

['Theetša letlakala le']

Bolwetši bja Alzheimer bo lemogwa bjang?

Bolwetši bja Alzheimer bo lemogwa ka go diriša mekgwa e fapa-fapanego, go akaretša go hlahlobja ka botlalo ke ngaka, diteko tša go tseba le tša monagano, go dirwa ga diswantšho tša bjoko le go phengwa ga dilo tše dingwe tšeo di ka bago di bo bakile.

1. Tekolo ya tša kalafo: Ngaka e tla dira tlhahlobo ya mmele le go tšea pego e tseneletšego ya tša kalafo go bona ge e ba go na le dilo tše dingwe tšeo di ka bakago go lahlegelwa ke monagano goba go fokola ga bokgoni bja go nagana, tše bjalo ka mathata a kgeleswa ya thyroid, go hlaelela ga dibithamine goba dikankere tša bjoko.

Diteko tša go lemoga le tša go laola monagano: Diteko tše di hlahloba go gopola, leleme, go rarolla mathata le mediro e mengwe ya go lemoga go bona tekanyo ya go fokola ga go lemoga le go kgethologanya go lahlegelwa ke go gopola mo go tlwaelegilego mo go tswalanago le botšofadi le bolwetši bja monagano.

Go tšea diswantšho tša bjoko: Magnetic resonance imaging (MRI) goba go tšea diswantšho tša computer tomography (CT) go ka thuša go hlaola diphetogo tša sebopego sa bjoko tšeo di ka bontšhago bolwetši bja Alzheimer.

Go dirwa ga di-positron emission tomography (PET) scans go ka dirišwa gape go lekanya ditekanyo tša diproteine tše itšego tšeo di tswalanago le bolwetši bja Alzheimer.

4. Diteko tša madi: Nyakišišo ya morago bjale e bontšhitše gore diteko tše dingwe tša madi di ka thuša go hlaola bolwetši bja Alzheimer ka go ela tekanyo ya diproteine tše itšego goba di-biomarker tšeo di tswalanago le bolwetši.

5. Tshepedišo ya go e tloša: Ka ge go se na teko e tee e kgonthišetšago bolwetši bja Alzheimer, go bo hlaola gantši go akaretša go tloša dilo tše dingwe tšeo di ka bakago dika tše di swanago le tša go lahlegelwa ke monagano.

Go bohlokwa go lemoga gore tlhahlobo e kgonthišeditšwego ya bolwetši bja Alzheimer e ka dirwa feela ka morago ga lehu ka go hlahloba dithishu tša bjoko.

Lega go le bjalo, mekgwa ya gona bjale ya go hlahloba bolwetši e ka nea tekanyo e phagamego ya kgonthišetšo ya go hlahloba bolwetši ge motho a sa phela.

Go lemoga bolwetši e sa le ka pela go bohlokwa bakeng sa go thoma kalafo le go rulaganya bokamoso.

['Ditšhupetšo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

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Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

['Boikano: bja tša kalafo']

['Wepesaete ye e neetšwe feela bakeng sa go ruta le go nea tsebišo gomme ga e nee keletšo ya tša kalafo goba ditirelo tša tša kalafo.']

['Tsebišo yeo e neilwego ga se ya swanela go dirišwa bakeng sa go hlahloba goba go alafa bothata bja tša maphelo goba bolwetši, gomme bao ba nyakago keletšo ya tša kalafo ya motho ka noši ba swanetše go boledišana le ngaka yeo e nago le tumelelo.']

['Ka kgopelo lemoga gore netweke ya methapo yeo e tšweletšago dikarabo tša dipotšišo, ga e nepagale kudu ge go tliwa go diteng tša dinomoro. Ka mohlala, palo ya batho bao ba hweditšwego ba na le bolwetši bjo bo itšego.']

['Ka mehla nyaka keletšo ya ngaka ya gago goba mofani yo mongwe wa tlhokomelo ya tša maphelo yo a nago le bokgoni mabapi le boemo bja tša kalafo. Le ka mohla o se ke wa hlokomologa keletšo ya tša kalafo goba wa diega go e nyaka ka baka la selo seo o se badilego wepesaeteng ye. Ge e ba o nagana gore o ka ba o le boemong bja tšhoganetšo bja tša kalafo, leletša 911 goba o ye phapošing ya tšhoganetšo ya kgauswi le wena kapejana. Ga go na tswalano ya ngaka le molwetši yeo e bopšago ke wepesaete ye goba go e diriša. BioMedLib goba bašomi ba yona, goba motho le ge e le ofe yo a tsenyago letsogo wepesaeteng ye, ga ba dire ditshepišo le ge e le dife, e ka ba tše di boletšwego ka go lebanya goba tše di sa hlaloswago gabotse, mabapi le tsebišo yeo e neilwego mo goba go e diriša.']

['Go se tšee karolo: tokelo ya ngwalollo']

['Molao wa Digital Millennium Copyright wa 1998, 17 U.S.C. § 512 (DMCA) o nea baamogedi ba tokelo ya ngwalollo bao ba dumelago gore dilo tšeo di tšwelelago ka go Inthanete di tshwenyana le ditokelo tša bona ka tlase ga molao wa U.S. wa tokelo ya ngwalollo. ']

['Ge e ba o dumela ka potego gore diteng goba dilo tšeo di lego mabapi le wepesaete ya rena goba ditirelo di tshwenyana le tokelo ya gago ya go gatiša, wena (goba moemedi wa gago) o ka re romela tsebišo ya gore o kgopele gore diteng goba dilo tšeo di tlošwe goba gore o thibelwe go di fihlelela. ']

["Ditsebišo di swanetše go romelwa ka go ngwala ka emeile (lebelela karolo ya 'Kgokagano' go hwetša aterese ya emeile). "]

['DMCA e nyaka gore tsebišo ya gago ya go pharwa ga molao wa tokelo ya ngwalollo e akaretše tshedimošo ye e latelago: (1) tlhaloso ya mošomo wa tokelo ya ngwalollo wo o pharwago ka molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa go pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa go pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao wa pharwa ga molao.']

['(5) setatamente sa gago, seo se saennwego ka tlase ga kotlo ya go bolela maaka, gore tshedimošo yeo e lego tsebišong e nepagetše le gore o na le maatla a go phethagatša ditokelo tša mongwadi tšeo go thwego di a gatakelwa; ']

['le (6) tshaeno ya kgonthe goba ya elektroniki ya mong wa tokelo ya ngwalollo goba motho yo a dumeletšwego go dira legatong la mong wa tokelo ya ngwalollo. ']

['Go palelwa ke go akaretša tshedimošo ka moka ya ka godimo go ka dira gore go šongwa ga ngongorego ya gago go diege.']

['Go Ikgokaganya']

['Re romele imeile ka kgopelo le ge e le efe goba tšhišinyo.']

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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