What is pathophysiology of Diabetes?

['Dengel mo iyan pahina']

Anto so pathophysiology na diabetes?

Say pathophysiology na diabetes et ontutukoy ed panagaral ed saray ag-agawaan a proseso na laman ya pansesengegan na diabetes mellitus.

Say diabetes mellitus et sakey a grupo na sakit ya nalilikna na saray pasyente lapud atagey so blood sugar (glucose) da.

Say pathophysiology na diabetes et nalalanor so komplikadon pandurumaan na genetic, environmental, tan lifestyle factors ya sengegan na sakit.

Diad type 1 diabetes, say pathophysiology et lapud autoimmune destruction na saray beta cell ya mamapawala na insulin diad pancreas, kanian kulang so insulin ya papawalaen na satan.

Lapud satan et agla nakontrol so blood glucose, kanian ombabaleg so blood sugar.

Diad type 2 diabetes, mas komplikado so pathophysiology tan nalalanor so insulin resistance tan impaired insulin secretion.

Say insulin resistance et no ag-ondengel iray selula ed insulin, kanian ag-ira makausar na glucose pian nawalaay enerhiya.

Lapud satan, say pancreas et mamapawala na mas dakel ya insulin pian nalabanan so resistensya, balet diad ilabas na panaon et agla nagawaan na pancreas so amin ya kaukolan to, kanian ondaiset so insulin ya papawalaen to.

Say gestational diabetes, ya nagagawa legan na panlukon, et resulta na hormonal changes ya manresulta ed insulin resistance.

Say placenta so mamapawala na saray hormone a nayarin mangamper ed ikikiwas na insulin, a manresulta ed itatagey na glucose ed dala.

Say pathophysiology na diabetes et mangilalanor met ed pakawalaay komplikasyon, a singa say pakaderal na saray blood vessel, nerves, tan organ, a nayarin manresulta ed graben sakit a singa say sakit ed puso, stroke, sakit ed bato, tan pakakabulag.

Importante so pakatalos ed pathophysiology na diabetes pian napawala iray epektibon paraan na panagtambal tan pan-prevent ed sayan graben sakit.

['Saray reperensya']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

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What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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