What is pathophysiology of Breast cancer?

Dhageyso boggan

Waa maxay pathophysiology-ka kansarka naasaha?

Pathophysiology of breast cancer waxaa loola jeedaa isbeddelada aan caadiga ahayn ee geeddi-socodka caadiga ah ee jirka iyo hababka dhaca horumarinta iyo horumarka kansarka naasaha.

Waxay ku lug leedahay daraasadda hababka bayoolojiga iyo molecular-ka ah ee keena koritaanka aan la xakamayn karin iyo faafitaanka unugyada kansarka ee unugyada naasaha.

Tan waxaa ka mid ah waxyaabaha hiddo-wadaha, hiddo-wadaha, iyo arrimaha deegaanka ee gacan ka geysta bilowga, horumarinta, iyo horumarka kansarka naasaha.

Qaar ka mid ah isbedelada muhiimka ah ee pathophysiological ee kansarka naasaha waxaa ka mid ah:

1. Isbedelada hiddo-wadaha: Isbedelada hiddo-wadaha qaarkood, sida BRCA1 iyo BRCA2, waxay kordhin karaan halista kansarka naasaha.

Kala duwanaanshahan waxaa la dhaxli karaa ama la heli karaa inta qofku nool yahay.

2. Isku dheelitir la'aanta hormoonnada: Hormoonnada, gaar ahaan estrogen, waxay door ka ciyaari karaan horumarinta iyo koritaanka kansarka naasaha.

Isku dheelitir la'aanta heerarka hormoonnada ama soo-gaadhista estrogen-ka xad dhaafka ah waxay kordhin kartaa halista kansarka naasaha.

3. Caabuqa: Caabuqa joogtada ah ee unugyada naasaha wuxuu gacan ka geysan karaa horumarinta kansarka naasaha isagoo kor u qaadaya koritaanka iyo badbaadada unugyada kansarka.

4. Deegaanka unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada unugyada

5. Metastasis: Kansarka naasaha wuxuu ku faafi karaa qaybaha kale ee jirka iyada oo loo marayo nidaamka lymphatic ama dhiigga, taasoo keenta sameynta burooyinka labaad ee xubnaha fog.

Fahamka cudurka kansarka naasaha wuxuu muhiim u yahay horumarinta ka hortagga wax ku oolka ah, ogaanshaha hore, iyo istiraatiijiyadaha daaweynta.

Tixraacyada

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.

Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.

Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.

Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.

Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.

Diidmada masuuliyada: caafimaadka

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DMCA waxay u baahan tahay in ogeysiiskaaga ku saabsan xadgudubka xuquuqda daabacaadda ee la sheegay uu ku jiro macluumaadka soo socda: (1) sharaxaadda shaqada xuquuqda daabacaadda ee ay ku saabsan tahay xadgudubka la sheegay; (2) sharaxaadda nuxurka xadgudubka la sheegay iyo macluumaadka ku filan ee noo oggolaanaya inaan helno nuxurka; (3) macluumaadkaaga xiriirka adiga, oo ay ku jiraan cinwaankaaga, lambarka taleefanka iyo cinwaanka emaylkaaga; (4) bayaan aad ku leedahay aaminaad wanaagsan oo ah in nuxurka habka lagu cabiray uusan oggolaan milkiilaha xuquuqda daabacaadda, ama wakiilkiisa, ama hawlgalka sharci kasta;

(5) bayaan aad saxiixday oo aad ku cadeyneyso in macluumaadka ku jira ogeysiiska uu sax yahay iyo in aad awood u leedahay in aad dhaqan geliso xuquuqda daabacaadda ee la sheeganayo in la jabiyay;

iyo (6) saxiix jireed ama elektaroonig ah oo ka yimid milkiilaha xuquuqda daabacaadda ama qof loo oggol yahay inuu ku dhaqmo magaca milkiilaha xuquuqda daabacaadda.

Haddii aadan ku darin dhammaan macluumaadka kor ku xusan waxay keeni kartaa dib u dhac ku yimaada ka baaraandegista cabashadaada.

Xiriirka

Fadlan noogu soo dir emayl su'aal kasta / soo jeedin.

What is pathophysiology of breast cancer?

Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.

It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.

This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.

Some of the key pathophysiological changes in breast cancer include:

1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.

These mutations can be inherited or acquired during a person's lifetime.

2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.

An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.

3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.

4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.

5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.

Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.

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