What causes Alzheimer?

['Harim dispela pes']

Wanem samting i save kamapim sik alsaima?

Sik Alsaima em wanpela sik we i save bagarapim kru na mekim man i lusim tingting long ol samting, na tingting bilong em i no wok gut, na pasin bilong em i senis.

Ol i no save gut long as tru bilong sik Alsaima, tasol ol i ting i gat sampela samting long skin, na long sindaun bilong man, na long ol samting i save stiaim ol samting em i mekim.

Sampela samting inap mekim na sik Alsaima i kamap em:

1. Ol samting i stap long skin bilong man: Ol i bin painim sampela jin i save mekim na man inap kisim sik Alsaima, na moa yet wanpela jin (apolipoprotein E (APOE).

2. krismas: Taim man i go lapun, dispela sik i save kamap bikpela moa, na planti man i kisim dispela sik taim ol i winim pinis 65 krismas.

3. Famili i gat sik Alsaima: Sapos wanpela long famili i gat dispela sik, dispela inap mekim na sik Alsaima inap kamap long famili.

4. Bagarapim Het: Sapos bipo yu bin kisim bagarap long het, na moa yet sapos yu bin hap indai, dispela inap mekim na yu kisim sik Alsaima.

5. Ol samting inap mekim na sik bilong klok i kamap: Sapos blut presa i go antap, mak bilong kolestrol long bodi i go antap, na sik daiabitis, dispela inap mekim na sik Alsaima i kamap bikpela moa.

6. Sindaun bilong man: Sapos man i sindaun nating, o em i no kisim gutpela kaikai, na em i no tingting gut, dispela inap mekim na em i kisim sik Alsaima.

7. Skin i solap: Sapos kru i solap oltaim, dispela inap mekim na man i kisim sik alsaima.

8. Sik bilong sik alsaima: Sapos bodi i no inap rausim ol marasin nogut long skin, dispela inap mekim na man i kisim sik alsaima.

9. Ol liklik hap hap bilong ol lip samting i gat marasin amiloid long en na ol liklik hap bilong ol rop samting i gat marasin amiloid long en i save bung long kru, em wanpela mak bilong sik Alsaima, tasol ol i no save gut long wok bilong ol long kamapim dispela sik.

Em i bikpela samting long tingim olsem as bilong sik Alsaima i gat planti samting long en na ating ol dispela samting i as bilong en.

Ol i mekim wok painimaut long ol samting i mekim na dispela sik i stap, na ol i laik painim rot bilong stretim dispela sik.

['Ol Tok Bilong Bipo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

['Toksave: sik']

['Dispela Web-sait i bilong skulim na givim save tasol long ol man, na i no bilong givim tok bilong helpim ol sikman o helpim ol narapela long sait bilong helt.']

['Ol i no ken yusim ol dispela tok bilong helpim ol long save long sik bilong ol, na ol man i laik kisim helpim long ol samting bilong helt, ol i mas toktok wantaim wanpela dokta.']

['Tingim, ol kompiuta i save yusim ol kompiuta long kamapim ol bekim bilong ol askim, tasol ol i no save kolim stret ol namba, olsem namba bilong ol man i gat wanpela sik.']

['Oltaim yu mas kisim tingting bilong dokta o narapela lain i gat save long helpim yu long sait bilong helt sapos yu gat sik. No ken sakim tok bilong dokta o wet long kisim tingting bilong dokta, long wanem, yu ritim sampela tok long dispela Web-sait. Sapos yu ting yu gat sik, ringim 911 o go long haus sik i stap klostu.']

['Toksave: raits bilong man i bosim']

['Digital Millennium Copyright Act bilong 1998, 17 U.S.C. § 512 (the DMCA) i tok ol papa bilong ol samting i gat rait long wokim ol samting, sapos ol i ting ol samting i stap long Intenet i brukim ol lo bilong ol long Amerika.']

['Sapos yu bilip olsem sampela samting i stap long dispela Web-sait o ol sevis bilong mipela i brukim lo bilong kopirait bilong yu, yu (o agent bilong yu) inap salim toksave long mipela na askim mipela long rausim o pasim rot bilong yu long kisim dispela samting.']

['Ol i mas salim ol toksave long rot bilong e-mail (lukim hap "Kontek" bilong lukim e-mail atres). ']

['Lo bilong DMCA i tok olsem toksave bilong yu long ol man i bin brukim lo bilong kopirait i mas i gat ol dispela tok: (1) stori long ol samting i gat kopirait long en, em ol man i tok ol i bin brukim; (2) stori long ol samting i gat kopirait na ol tok bilong helpim mipela long painim ol dispela samting; (3) ol tok bilong yu bilong salim pas long mipela, olsem atres, telefon namba, na e-meil atres; (4) tok yu bin mekim olsem yu bilip tru olsem man i gat kopirait o agent bilong em i no orait long ol samting i stap long dispela websait.']

['(5) Yu mas raitim wanpela pepa na putim han bilong yu bilong tokaut olsem ol tok bilong dispela pepa i stret na yu gat namba long mekim ol samting bilong lukautim ol rait bilong man i bin wokim ol samting.']

['Na (6) wanpela sain o sain bilong man i gat rait long wokim dispela samting o bilong wanpela man i gat namba long mekim wok bilong dispela man.']

['Sapos yu no raitim olgeta dispela tok, dispela inap mekim na ol i no stretim kwik komplen bilong yu.']

['Kontektim']

['Plis salim e-mail long mipela sapos yu gat sampela askim o tingting.']

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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