How is Alzheimer diagnosed?

['Engkalingai iyaé bagiyangngé']

Pékkugii riaddiagnosis alzheimer?

Penyakit Alzheimer riaddiagnosis sibawa kombinasi metode, matame' evaluasi medis iya sukku, tes kognitif nenniya neuropsikologis, pencitraan ota'e, nenniya proses penghapusan penyebab laing iya nulle e.

1. Assessment medis: Dokter e napajoppai assessment fisik sibawa malai sejarah medis iya rinci e untu' patentui saba' laing iya nulle nassabari ateddengeng amesseng iyarega ateddengeng kognitif, pada padanna masalah tiroid, akurangeng vitamin, iyarega tumor otak.

2. Tes kognitif nenniya neuropsikologis: Tes e ro napannessai memori, bahasa, solusi masalah, nenniya fungsi kognitif lainge untu' pattentui tingka' gangguan kognitif nenniya untu' mabberekkada antara ateddengeng memori na umuru' na demensia.

3. Imaging otak: Magnetic resonance imaging (MRI) iyarega computed tomography (CT) scans wedding bantui natentuangi perubahan struktural ri otak iya nulle mappaita lasa Alzheimer.

Positron emission tomography (PET) scans wedding toi ripakkeguna untu' naukkuru tingka'na protein mattentu iya sisompungnge sibawa lasa Alzheimer.

4. Analisis dara: apparessang makokoe pura mappaitangngi majeppu analisis dara mattentu nulle bantu nasappai lasa Alzheimer nasibawai naukkuru tingka' protein mattentu iyarega biomarker iyya sisompung sibawa lasa e.

5. Proses eliminasi: Nasaba degaga seddi tes definitif untu' lasa Alzheimer, diagnosis maderri mattama'i de'na engka alasang laing untu' gejala pappada demensia.

Parellu riisseng majeppu diagnosis pasti pole lasa Alzheimer wedding ripogau bawang purana amateng naolai ujian jaringan ota'e.

Namuni, metode diagnostik makkokkoe nulle mabbere tingka' mattentu matanre untu' diagnosis klinis riwettu tau e tuo mupa.

Diagnosis pammulang parellu untu' pammulai pabbura nenniya perencanaan untu' wettu mangoloe.

['Rilaleng']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

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How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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