Pathophysiology of colon cancer iyanaritu mekanisme nenniya proses dasar iya nassabari pallebangeng nenniya allebbangenna kanker kolon.
Kanker kolon, riaseng toi sebagai kanker kolorektal, iyanaritu rupanna kanker iya ripammulai ri kolon iyarega rektum, iyanaritu bageang pole ri usus maraja.
Purana kanker usus maraja mallebbang, nulle mallebbang lalo siare tahap, pole kanker tahap pammulang iya tassibatasi ri usus maraja lettu tahap lebbi maju tegana kanker e mallebbang lao ri bageang lainge watakkalena.
Sel kanker e wedding narajang jaringan nenniya organ macawe'e, nenniya wedding to mallebbang lalo sistem limfatik iyarega aliran dara lao ri onrong mabelae, pappada ati iyarega paru-paru.
Perawatan untu' kanker usus maraja biasanna naputtama kombinasi operasi, kemoterapi, nenniya terapi radiasi, taggattung ri tahap nenniya onrong kanker.
Deteksi nenniya perawatan pammulang iyanaritu kunci untu' napamenceng wassele, nasaba kanker usus maraja maderri wedding ripajjappa narekko riita ri tahap pammulangna.
Seleksi maderri, pappada kolonoskopi, nulle bantu runtui kanker usus maraja ri tahap pammulangna, wettunna kaminang wedding ripajjappa.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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