Mae pathophysiology canser y prostad yn cyfeirio at y mecanweithiau a'r prosesau sylfaenol sy'n arwain at ddatblygiad a cynnydd y clefyd.
Mae canser y prostad yn tiwmor peryglus sy'n deillio o gelloedd y gland prostad, sy'n organ bach sy'n siâp walnut sy'n cael ei leoli o dan y chwistrell mewn dynion.
Mae'r gland prostate yn cynhyrchu hylif seminol, sy'n maethu ac yn cludo sberm.
Nid yw'r achos cywir o ganser y prostad yn cael ei ddeall yn llawn, ond mae sawl ffactor yn hysbys i gynyddu'r risg o ddatblygu'r clefyd.
Mae'r rhain yn cynnwys oedran, hanes teuluol, hil, a rhai mudiadau genetig.
Mae canser y prostad yn fwy cyffredin mewn dynion hŷn, gyda'r rhan fwyaf o achosion yn digwydd mewn dynion dros 65 oed.
Yn ogystal, mae dynion sydd â hanes teuluol o ganser y prostad mewn perygl uwch, yn ogystal â dynion Affricanaidd-Americanaidd a dynion o ddisgynyddion y Caribî.
Mae pathophysiology canser y prostad yn cynnwys twf a rhannu celloedd heb reolaeth o fewn y gland prostad.
Gall hyn ddigwydd oherwydd mudiadau genetig sy'n arwain at orymdeimlad o rai ffactorau twf neu anweithrediad gennau atal tiwmor.
Gall y mudiadau hyn arwain at dyfu celloedd heb ei reoleiddio, gan arwain at ffurfio tiwmor.
Wrth i'r tiwmor dyfu, gall ymosod ar feinweoedd ac organau cyfagos, fel y chwistrell, y rectum, a'r nodau limff cyfagos.
Mewn rhai achosion, gall celloedd canser dorri i ffwrdd o'r tiwmor sylfaenol a lledaenu i rannau eraill o'r corff trwy'r ffrwd gwaed neu'r system limffig, proses a elwir yn metastasis.
Unwaith y mae'r canser wedi lledaenu, gall fod yn anoddach ei drin.
Gall canser y prostad hefyd gael ei ddylanwadu gan ffactorau hormonol, yn enwedig y hormon androgen testosterone.
Gall testosterone ysgogi twf celloedd canser y prostad, ac mae llawer o driniaethau ar gyfer canser y prostad yn anelu at leihau lefelau'r hormon hwn neu atal ei effeithiau.
Mewn crynodeb, mae pathophysiology canser y prostad yn cynnwys twf a rhannu celloedd heb reolaeth o fewn y gland prostate, a all fod yn cael ei ddylanwadu gan ffactorau genetig, hormonol ac amgylcheddol.
Mae deall mecanweithiau sylfaenol y clefyd yn hanfodol ar gyfer datblygu triniaethau effeithiol a gwella canlyniadau ar gyfer cleifion â chanser prostad.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
Gwaharddiad cyfrifoldeb: meddygol
Mae'r wefan hon yn cael ei ddarparu at ddibenion addysgol a gwybodaeth yn unig ac nid yw'n darparu cyngor meddygol neu wasanaethau proffesiynol.
Ni ddylid defnyddio'r wybodaeth a ddarperir i ddiagnosio neu drin broblem neu glefyd iechyd, a dylai'r rhai sy'n ceisio cyngor meddygol personol ymgynghori â meddyg trwyddedig.
Sylwch fod y rhwydwaith niwrol sy'n cynhyrchu atebion i'r cwestiynau, yn arbennig o anghywir pan ddaw i gynnwys rhifol. Er enghraifft, nifer y bobl sy'n cael diagnosis o glefyd penodol.
Ceisiwch gyngor eich meddyg neu ddarparwr iechyd cymwys arall bob amser ynghylch cyflwr meddygol. Peidiwch byth ag anwybyddu cyngor meddygol proffesiynol neu ohirio ei geisio oherwydd rhywbeth rydych chi wedi ei ddarllen ar y wefan hon. Os ydych chi'n meddwl y gallai fod gennych argyfwng meddygol, ffonwch 911 neu ewch i'r ystafell brys agosaf ar unwaith. Nid oes unrhyw berthynas meddyg-cleifion yn cael ei greu gan y wefan hon na'i ddefnydd. Nid yw BioMedLib na'i weithwyr, na unrhyw gyfrannwr i'r wefan hon, yn gwneud unrhyw gynrychiolaeth, yn glir neu'n awgrymol, mewn perthynas â'r wybodaeth a ddarperir yma na'i ddefnydd.
Gwrthod cyfrifoldeb: hawlfraint
Mae Deddf Hawlfraint y Mileniwm Digidol o 1998, 17 U.S.C. § 512 (y DMCA) yn darparu adnodd i berchnogion hawlfraint sy'n credu bod deunydd sy'n ymddangos ar y Rhyngrwyd yn torri eu hawliau o dan gyfraith hawlfraint yr Unol Daleithiau.
Os ydych chi'n credu mewn ffydd da bod unrhyw gynnwys neu ddeunydd a wnaed ar gael mewn cysylltiad â'n gwefan neu'n gwasanaethau yn torri eich hawlfraint, gallwch chi (neu'ch asiant) anfon hysbysiad atom yn gofyn i'r cynnwys neu'r ddeunydd gael ei ddileu, neu fod mynediad ato wedi'i rwystro.
Rhaid i rybuddion gael eu hanfon yn ysgrifenedig trwy e-bost (gweler adran "Cyflwyniad" am gyfeiriad e-bost).
Mae'r DMCA yn gofyn i'ch hysbysiad o dorri hawlfraint honedig gynnwys y wybodaeth ganlynol: (1) disgrifiad o'r gwaith hawlfraint sy'n destun y dorri hawlfraint honedig; (2) disgrifiad o'r cynnwys sy'n dorri hawlfraint honedig a gwybodaeth ddigonol i'n galluogi i ddod o hyd i'r cynnwys; (3) gwybodaeth gyswllt i chi, gan gynnwys eich cyfeiriad, rhif ffôn a chyfeiriad e-bost; (4) datganiad gan chi bod gennych gred ffyddlon nad yw'r cynnwys yn y ffordd sy'n cwyno amdano wedi'i awdurdodi gan berchennog yr hawlfraint, neu ei asiant, neu gan weithredu unrhyw gyfraith;
(5) datganiad gennych chi, wedi'i lofnodi o dan gosb llygredd, bod y wybodaeth yn y hysbysiad yn gywir ac bod gennych chi'r awdurdod i orfodi'r hawlfraint sy'n cael eu troseddu;
a (6) llofnod corfforol neu electronig o berchennog y hawlfraint neu berson wedi'i awdurdodi i weithredu ar ran perchennog y hawlfraint.
Gall methu â chynnwys yr holl wybodaeth uchod arwain at oedi wrth brosesu'ch cwyn.
Cysylltwch
Anfonwch e-bost i ni gyda unrhyw gwestiwn / awgrym.
What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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