What is pathophysiology of Colon cancer?

['A lamɛn']

Bana min be mɔgɔ fari faga ka tɛmɛ, o ye mun lo ye?

Bana min be mɔgɔ fari faga, o ye kansɛri ye.

Kɔnɔnatumuni, min bɛ wele fana ko kansɛri, ye kansɛri suguya dɔ ye min bɛ daminɛ kɔkolo la walima kankɔnɔna na, min ye nuguba yɔrɔ dɔ ye.

A daminɛ na, a be kɛ i n'a fɔ sumuni min be bonya ani a be yɛlɛma ka kɛ kansɛri ye.

Bana min be mɔgɔ minɛ ka caya biɲɛdimi na, o sababuw ye bana dɔw ye i n'a fɔ joli yɛlɛmacogo, sumaya, ani lamini nɔɔ.

Zɛnɛtiki yɛlɛmaniw be se ka kɛ joli siraw fɛ ka wolo kɔrɔ ani ka wolo kɔrɔw kolow yɛlɛma.

O yɛlɛmaniw be se ka kɛ wolo fɛ wala mɔgɔ yɛrɛ lo ye.

Kɔnɔboli min be se ka kɛ bana dɔw sababu ye i n'a fɔ kɔnɔboli, o fana be se ka kansɛri farati bonya.

Farikolokisɛw be falenfalen ani u be tila ka kɛ joli ye.

Ɲɛnamaya kɛcogo, dumuni nafama dunni ani bagaji dɔw tali fana be se ka kɛ sababu ye ka kansɛri lase mɔgɔ ma.

O kama, a ka ɲi an k'an yɛrɛ kɔrɔsi.

Koo wɛrɛw be se k'a to fana a ka teli ka kɛ ten: sumaya, sigarɛtimin ani farilajidɛsɛ.

Ni kansɛri donna mɔgɔ kɔnɔ, a be se ka yɛlɛma ka kɛ bana suguya caaman ye.

Kansɛri ka seliliw be se ka don fari yɔrɔ dɔw la ani ka jɛnsɛn joli sira fɛ ka se yɔrɔjanw na i n'a fɔ biɲɛ wala biɲɛ.

A ka ca a la, kansɛri furakɛli bɛ kɛ ni kirinni ye, ka joli furakɛ ni bagafuraw ye ani ka joli furakɛ ni kirinni ye.

A ka fisa ka kɔn ka banaw furakɛ joona, barisa ni kansɛri daminɛna joona, a ka teli ka kɛnɛya.

O la, a ka nɔgɔ k'a furakɛ joona.

['Kunnafoni wɛrɛw']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.

Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.

Chen JK, Yaffe MB: Atlas Drugged. Cell. 2019, 177 (4): 803-805.

Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.

Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.

Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.

Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.

['Kunnafoni nafaman: furakɛli']

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["Mɔgɔ minw b'o gafew kalan, olu man kan k'u kɛ ka bana dɔw furakɛ."]

['Aw ye aw janto nin na: ɛntɛrinɛti min bɛ ɲiningaliw jaabiw labɛn, a tɛ se ka jatidenw fɔ ka ɲɛ. misali la, bana kɛrɛnkɛrɛnnen dɔ bɛ mɔgɔ minw na.']

["Tuma bɛɛ i ka kan ka ladili ɲini i ka dɔgɔtɔrɔ fɛ wala kɛnɛya baarakɛla dɔ fɛ bana dɔ koo la. I kana ban ka ladili ɲini dɔgɔtɔrɔ fɛ wala ka mɛɛn a ɲinili la sabu i ye koo dɔ kalan site web nin kan. N'i miirila ko bana dɔ be i kan, i ka kan ka teliya ka mɔgɔ wele 911 wala ka taga dɔgɔtɔrɔso la joona joona."]

['Kunnafoniw: sɛbɛkɔrɔ']

["Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (DMCA) ye sariya dɔ ye min b'a to mɔgɔ minw b'u ka gafew sɔrɔ ɛntɛrinɛti kan, olu ka se k'u yɛrɛ lafasa."]

["N'i lanin b'a la ko kunnafoni wala fɛɛn o fɛɛn be sɔrɔ an ka site web kan wala an ka baaraw kan, k'o be i ka sariya tiɲɛ, i (wala i ka lasigiden) be se k'o kunnafoni wala fɛɛn bɔ yen wala k'a bali k'a sɔrɔ."]

['I ka kan ka ci nin ci nin kɛ e-mail fɛ (i ka e-mail lajɛ yɔrɔ nin na)']

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["5. i ka sɛbɛ dɔ kɛ ka yira ko i ye tiɲɛn fɔ ani ko joo b'i fɛ ka joo dɔ latanga."]

["O kama, a ka ɲi i k'a ɲini k'a lɔn n'i ka ɲi k'o gafew wala videwo nunu jati k'u ye gafew ye minw labɛnna mɔgɔw ye."]

["N'i ma kunnafoni nunu bɛɛ di, a be se ka kɛ ko i ka ɲinini baara be mɛɛn."]

['Kumaɲɔgɔnya kɛ']

["N'i ka ɲiningaliw wala i ka ladiliw be yen, an ci e-mail fɛ."]

What is pathophysiology of colon cancer?

The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.

Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.

It typically starts as a growth called a polyp, which can develop into cancer over time.

The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.

Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.

Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.

Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.

Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.

A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.

Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.

Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.

The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.

Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.

Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.

Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.

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