La orticarie, cognossude pal solit come orticarie, e je une condizion de piel caraterizade de comparizion di grîs ros, jevadis e rialzadis su la piel.
La fisiopatologjie de orticarie e rivuarde il rilassi di istamine e altris mediadôrs de infiammazion dai mastocits, che a son celulis imunitariis cjatadis inte piel e altris tiessûts.
Inte orticarie agude, il rilasci di istamine e altris mediadôrs al è provocât di une reazion allergiche a un specific alergjen, come un mangjâ, une medicazion o une punture di inset.
Chest al cause i mastocits a degranulâsi, molant fûr istamine e altris mediadôrs che a fasin deventâ i vasions sanguins permeabii, puartant ae formazion di rocs.
Inte orticarie croniche, la cause no je cognossude, ma e si pense che e sedi corelade a un mecanisim autoimun.
In chest câs, il cuarp al prodûs autoanticorps che smirin il ricevidôr IgE a alte afinitât (FcεRI) sui mastocits, puartant ae lôr ativazion e al rilasci di istamine e altris mediadôrs.
Te urticarie sedi acute sedi croniche, il rilasci di istamine e altris mediadôrs al puarte ai sintoms carateristics di prurît, ros e tumefazion.
Il tratament al impliche par solit l'ûs di antistaminis par blocâ i efiets de istamine e ridusi i sintoms.
In câs severis, par controlâ la cundizion a puedin jessi doprâts altris medisinis come i corticosteroits o omalizumab.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
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What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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