Tha pathophysiology aillse broilleach a 'toirt iomradh air na h-atharrachaidhean anabarrach anns na pròiseasan agus na h-innealan fiseòlasach àbhaisteach a tha a' tachairt ann an leasachadh agus adhartas aillse broilleach.
Tha e a' toirt a-steach sgrùdadh air na h-innealan bith-eòlasach agus moileciuil bunaiteach a tha a' leantainn gu fàs agus sgaoileadh neo-riaghlaichte cheallan aillse ann an clò na broilleach.
Tha seo a 'toirt a-steach na factaran ginteil, epigenetic, agus àrainneachd a tha a' cur ri tòiseachadh, adhartachadh, agus adhartas aillse broilleach.
Tha cuid de na prìomh atharrachaidhean pathophysiological ann an aillse broilleach a 'toirt a-steach:
1. Atharrachaidhean ginteil: Faodaidh atharrachaidhean ann an gineachan sònraichte, leithid BRCA1 agus BRCA2, an cunnart a bhith a 'leasachadh aillse broilleach a mheudachadh.
Faodaidh na h-atharrachaidhean sin a bhith air an oighreachadh no air an faighinn rè beatha neach.
2. Mì-chothromachadh hormonail: Faodaidh hormona, gu sònraichte estrogen, pàirt a ghabhail ann an leasachadh agus fàs aillse broilleach.
Faodaidh mì-chothromachadh ann an ìrean hormona no nochdadh gu cus estrogen an cunnart aillse broilleach a mheudachadh.
3. Inflammation: Faodaidh sèid leantainneach anns an fhèith broilleach cur ri leasachadh aillse broilleach le bhith a 'brosnachadh fàs agus mairsinn cheallan aillse.
4. Microenvironment Tumor: Faodaidh an àrainneachd a tha timcheall air a 'chnàmh, a' toirt a-steach am matrix extracellular, ceallan dìon, agus soithichean fala, buaidh a thoirt air fàs agus sgaoileadh aillse broilleach.
5. Metastasis: Faodaidh aillse broilleach sgaoileadh gu pàirtean eile den bhodhaig tron t-siostam lymphatic no sruth fala, a 'leantainn gu cruthachadh tumors àrd-sgoile ann an organan fad às.
Tha tuigse air pathophysiology aillse broilleach deatamach airson ro-innleachdan casg, lorg tràth, agus làimhseachaidh èifeachdach a leasachadh.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
['Àicheadh: meidigeach']
["Tha an làrach-lìn seo air a thoirt seachad airson adhbharan foghlaim agus fiosrachaidh a-mhàin agus chan eil e a' toirt seachad comhairle mheidigeach no seirbheisean proifeiseanta."]
["Cha bu chòir am fiosrachadh a chaidh a thoirt seachad a chleachdadh airson duilgheadas slàinte no galar a dhearbhadh no a làimhseachadh, agus bu chòir dhaibhsan a tha a'sireadh comhairle meidigeach pearsanta co-chomhairle a chumail ri lighiche-sprèidh."]
["Thoiribh fa-near gu bheil an lìon neural a tha a' cruthachadh fhreagairtean do na ceistean, gu sònraichte neo-chruinneasach nuair a thig e gu susbaint àireamhach. Mar eisimpleir, an àireamh de dhaoine a chaidh a dhearbhadh le galar sònraichte."]
["Faigh comhairle an dotair agad no solaraiche slàinte eile a tha airidh air comhairle a thaobh tinneas meidigeach. Na dì-meas comhairle meidigeach proifeiseanta no dàil ann a bhith ga shireadh air sgàth rudeigin a leugh thu air an làrach-lìn seo. Ma tha thu a'smaoineachadh gum faodadh èiginn meidigeach a bhith agad, cuir fòn gu 911 no rachaibh chun t-seòmar èiginn as fhaisge sa bhad. Chan eil dàimh dotair-euslainteach air a chruthachadh leis an làrach-lìn seo no a chleachdadh. Chan eil BioMedLib no a luchd-obrach, no neach sam bith a tha a' cur ris an làrach-lìn seo, a 'dèanamh riochdachaidhean sam bith, fosgailte no a' toirt a-steach, a thaobh an fhiosrachaidh a tha air a thoirt seachad an seo no a chleachdadh."]
['Àicheadh: còraichean']
["Tha Achd Dlighe-sgrìobhaidh na Mìle Bliadhna Didseatach 1998, 17 U.S.C. § 512 (an DMCA) a' toirt ath-chuinge do shealbhadairean dlighe-sgrìobhaidh a tha den bheachd gu bheil stuth a tha a' nochdadh air an eadar-lìon a' briseadh an còraichean fo lagh dlighe-sgrìobhaidh na SA. "]
["Ma tha thu a' creidsinn ann an deagh chreideamh gu bheil susbaint no stuth sam bith a tha ri fhaotainn a thaobh ar làrach-lìn no ar seirbheisean a' briseadh d' dlighe-sgrìobhaidh, faodaidh tu fhèin (no an riochdaire agad) fios a chur thugainn ag iarraidh gun tèid an susbaint no an stuth a thoirt air falbh, no gun tèid cothrom a chur air. "]
["Feumar sanasan a chur ann an sgrìobhadh tro phost-d (faic an roinn 'Contact' airson seòladh puist-d). "]
["Tha an DMCA ag iarraidh gum bi am fiosrachadh a leanas anns an fhios agad mu bhriseadh còraichean-sgrìobhaidh a thathar ag ràdh: (1) tuairisgeul air an obair fo chòraichean-sgrìobhaidh a tha fo chasaid briseadh; (2) tuairisgeul air an t-susbaint a thathar ag ràdh a tha a 'briseadh agus fiosrachadh gu leòr gus leigeil leinn an t-susbaint a lorg; (3) fiosrachadh conaltraidh dhut, a' toirt a-steach do sheòladh, àireamh fòn agus seòladh puist-d; (4) aithris bhuat gu bheil creideas math agad nach eil an t-susbaint san dòigh a tha gearan air a cheadachadh le sealbhadair a 'chòraichean-sgrìobhaidh, no an neach-ionaid aige, no le gnìomh lagha sam bith; "]
['(5) Dearbhadh agaibh, air a shoidhnigeadh fo pheanas mionnachaidh, gu bheil am fiosrachadh san fhiosrachadh ceart agus gu bheil ùghdarras agaibh na còraichean-sgrìobhaidh a thathar ag ràdh a chaidh a bhriseadh a chur an gnìomh; ']
['agus (6) ainm-sgrìobhte corporra no eileagtronaigeach an t-sealbhadair dlighe-sgrìobhaidh no neach a tha ùghdarraichte a bhith ag obair às leth an t-sealbhadair dlighe-sgrìobhaidh. ']
["Ma dh'fhailicheas tu air a' ghearan agad a dheasachadh, faodaidh e dàil a chur air mura cuir thu a-steach am fiosrachadh gu lèir gu h-àrd."]
['Cuir fios thugainn']
['Cuir post-d thugainn le ceist / moladh sam bith.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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