What causes Alzheimer?

['Ehendu ko kuatiarogue']

Mba'e omoñepyrũ alzheimer?

Alzheimer mba'asy ningo peteĩ mba'asy oporombohasýva ñande rajyguépe, opoko meméva apytu'ũre, oporombohasy mandu'a jejavýpe, apytu'ũ ñemoambue ha iñambue teko.

Noñemyesakãporãi mba'etépa ogueru ko mba'asy, hakatu oñeimo'ã oĩha heta factor genético, ambiental ha estilo de vida.

Oĩ ambue mba'e ikatúva oporombohasy Alzheimer-gui:

1. Genética: Ojeikuaa oĩha ambue gen ombohetavéva riesgo ojeguereko hag̃ua Alzheimer mba'asy, ha'eve hína apolipoproteína E (APOE) gen.

2. Edad: riesgo ojeguerekóva Alzheimer-gui ojupive ohóvo ary reheve, hetave tapichápe ojejuhu 65 ary rire.

3. Hasykue ogapýpe: Oĩramo peteĩ ogaygua oguerekóva Alzheimer ikatu ombohetave upe mba'asy.

4. Akãrague akytã'ai: Akãrague akytã'ai ohasámava, ha'eve umi opytáva chugui inconsciente, ikatu ombohetave Alzheimer mba'asy.

5. Umi factor de riesgo cardiovascular: Umi condición taha'e presión arterial yvate, colesterol yvate ha diabetes ikatu ombohetave riesgo ojeguereko hag̃ua Alzheimer mba'asy.

6. Mba'e oikóva: jeiko oguapýva, tembi'u naiporãiva ha apytu'ũ ñemombytu'u'ỹ ikatu ombohetave Alzheimer-pegua mba'asy.

7. Inflamación: Inflamación crónica apytu'ũme ikatu oporombohasy Alzheimer-gui.

8. Estrés oxidativo: Peteĩ desequilibrio oĩva umi radical libre producción ha ñande rete capacidad omboyke hag̃ua umi tóxico ikatu hína oporombohasy Alzheimer-gui.

9. Placa amiloide ha maraña neurofibrilar: Placa amiloide ha maraña neurofibrilar ñembyaty cerebro-pe, ha'e peteĩ mba'e ojehechakuaáva Alzheimer mba'asy rehe, katu ndojeikuaaporãi mba'etépa hembiapo ko mba'asy ñemboguatápe.

Iporã ja'e mba'asy Alzheimer-pegua hasyetereiha ha ikatuha hína oĩ heta mba'e ojoajúva.

Ojehapereka hína ojeikuaave hag̃ua mba'éichapa oiko ko mba'asy ha toñemoheñói ñepohano oikoitéva ko mba'asy vaiete rehegua.

['Jehechapy']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

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["Ko marandu oñeme'ẽva ndojeporúi va'erã ojeikuaa térã oñepohano hag̃ua peteĩ problema de salud térã mba'asy, ha umi tapicha ohekáva consejo médico ha'eñoháme oñe'ẽva'erã peteĩ pohanohára ikatupyrýva ndive."]

["Ejesareko ta'ãngamýi ñandutigua omoheñóiva mbohovái porandukuérape, noĩporãi ojeipapávo papapy rehegua, techapyrã, tapichakuéra hasýva peteĩ mba'asýpe."]

["Akóinte eheka ne pohãnohára térã ambue pohanohára ikatupyrýva ñe'ẽ peteĩ mba'asýpe. Ani araka'eve remboyke térã reha'arõ'ỹ rehekávo ñe'ẽ pohanohára ikatupyrýva ñe'ẽ remoñe'ẽre ko ñanduti rendápe. Reimo'ãramo ikatuha reikotevẽ peteĩ mba'e hasýva, ehenoikuaa 911 térã tereho pya'e tasyópe. Ko ñanduti renda térã ijeporu ndojapói mba'eveichagua pohanohára ha hasýva jokupyty. BioMedLib, imba'apohára térã oimeraẽ tapicha oipytyvõva ko ñanduti rendápe, nomboajéi mba'eve, he'íva térã he'iséva, marandu oĩva ko'ápe térã ijeporu."]

['Copyright: Copyright']

["Pe Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (DMCA) ome'ẽ recurso umi copyright járape ogueroviáva umi mba'e ojehechaukáva Internet-pe opokovaiha iderecho rehe EE.UU. léi jehaiporãmby rehegua rupive. "]

["Rogueroviáramo añetehápe oimeraẽ mba'e térã tembiporu ojepurukuaáva ore ñanduti renda térã tembipurupyahu rupive opyrũha ne derécho rehe, nde (térã ne rembijokuái) ikatu oremondo peteĩ ñemomarandu ojerurévo ojeipe'a hag̃ua upe mba'e térã tembiporu, térã ojejokopa hag̃ua ijeike. "]

['Umi ñemomarandu oñemog̃uahẽva\'erã kuatia rupive, correo electrónico rupive (ojehecháta "Contacto" pe).']

["DMCA ojerure ne ñemomarandu rehe ejaposégui mba'evai ejaposéva rehe toike ko'ã mba'e: (1) tembiapo ojejaposéva rehegua ha'éva mba'evai; (2) jehaipy ha mba'ekuaarã ome'ẽva oréve jehaipyre ha'éva mba'evai ha ome'ẽva oréve pa'ũ rojuhu hag̃ua; (3) ne ñanduti veve, ne rendaite, ne pumbyry papapy ha ne ñanduti veve; (4) ñe'ẽme'ẽ erekóva rejeroviaha pe mba'evai ejaposéva rehe ndojeruréiha mba'evai apohára, imaranduhára térã léi."]

["5. peteî declaración nde rejapóva, remoîva nde réra ha remoîva'erâha nde jurúpe, umi mba'e oîva ñemomarandúpe oîmbaha añetehápe ha rerekoha pokatu remoañete haguâ umi derecho oje'éva nde rehe ojepoko vaiha;"]

["ha (6) peteĩ firma física térã electrónica copyright jára rehegua térã peteĩ tapicha omoneĩva oporoñemomba'e hag̃ua copyright jára rérape. "]

["Ndoikéi ramo opaite ko'ã mba'e ikatu ombohape nde denuncia ñemboguata."]

['Ñemboheraguapy']

["Remba'eporanduséramo térã ereko hag̃ua ne remiandu ehai oréve."]

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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