Patofisiologi diabetes nuduhake studi babagan proses fisiologis sing ora teratur sing nyebabake pangembangan diabetes mellitus.
Diabetes mellitus minangka klompok penyakit metabolik sing ditondoi kanthi kadar gula getih (glukosa) sing dhuwur amarga cacat ing sekresi insulin, aksi insulin, utawa kalorone.
Patofisiologi diabetes kalebu interaksi kompleks faktor genetik, lingkungan, lan gaya urip sing nyumbang kanggo pangembangan penyakit kasebut.
Ing diabetes tipe 1, patofisiologi kalebu karusakan autoimun saka sel beta sing ngasilake insulin ing pankreas, sing nyebabake kekurangan produksi insulin.
Iki nyebabake ora bisa ngatur kadar glukosa getih, sing nyebabake hiperglikemia (gula getih dhuwur).
Ing diabetes tipe 2, patofisiologi luwih rumit lan kalebu resistensi insulin lan gangguan sekresi insulin.
Resistensi insulin dumadi nalika sel-sel awak ora nanggapi insulin kanthi bener, nyebabake ora bisa nggunakake glukosa kanthi efektif kanggo energi.
Iki nyebabake pankreas ngasilake luwih akeh insulin kanggo nyoba ngatasi resistensi, nanging suwe-suwe, pankreas bisa uga ora bisa ngatasi panjaluk kasebut, sing nyebabake penurunan produksi insulin.
Diabetes gestasional, sing kedadeyan nalika meteng, disebabake dening owah-owahan hormon sing nyebabake resistensi insulin.
Plasenta ngasilake hormon sing bisa mblokir tumindak insulin, sing nyebabake kenaikan kadar glukosa getih.
Patofisiologi diabetes uga kalebu pangembangan komplikasi, kayata karusakan pembuluh getih, saraf, lan organ, sing bisa nyebabake masalah kesehatan sing serius kayata penyakit jantung, stroke, penyakit ginjel, lan mundhut penglihatan.
Ngerti patofisiologi diabetes penting banget kanggo ngembangake perawatan lan strategi pencegahan sing efektif kanggo penyakit kronis iki.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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