D acu i d tafizitulujit n waṭṭan n ukansir n waḍu?
Tasnudert n tdawsa n unfafad bu uqacuc tga azal i ibeddilen deg tsuda d yimikanen n tfizitologit ig nnumen i d-iḍerrun deg usnulfu d ufara n unfafad bu uqacuc.
Aṭṭan n unfafad bu uεebbuḍ d aṭṭan yemgaraden i d-yettasen seg tuget ur nettwaḥkem d beṭṭu n yiɣsan ur nṣeḥḥa deg uεebbuḍ.
Izirigen-a zemren ad sbedden tigujilin u ad ten-ssenzlen ɣer yimukan nniḍen n tfekka, ayen yettawin ɣer waṭas n yisumar d wuguren.
Tasnudert n tdawsa n ukunsir n waḍu tettawi-d ɣef waṭas n yimgan, gar-asen ibeddilen ijenṭiyen, imgan n twennaḍt d wamek yettwafren tudert.
Imuttiyen ijenṭiyen zemren ad d-ilin deg DNA n yifuyla n waḍu, d ayen yettawin ɣer unefli d beṭṭu ur nettwaḥkem ara n yifuyla.
Imuttiyen-a zemren ad ttwaṛebbin neɣ ad d-ɣlin, yerna zemren ad d-ilin imi d-ttwaɣen s imuddiren imsenṭaḍen, am ddexxan n ddexxan, radon, asbestos, d usluɣu n ubeḥri.
Aṭṭan n waṭṭan n ubeḥri yezmer ad yettwassenyez ɣef sin n leṣnaf imeqqranen: Aṭṭan n ubeḥri n tsilunin timecṭuḥin (SCLC) d win n ubeḥri ur nelli ara n tsilunin timecṭuḥin (NSCLC). NSCLC yettwabḍa daɣen ɣef kraḍ n leṣnaf: adenokarcinoma, karcinoma n tsilunin tiferkitin, d karcinoma n tsilunin timeqranin.
Tussna n tfizikt n waṭṭanen n ukunsir n waḍu tezmer ad temgarad, imi sεan ibeddilen ijenṭiyen yemgaraden yerna ttemririn-d akken nniḍen i usafar.
Tasnudert n tdawsa n unfafad bu uqacuc teḥwaj daɣen assaɣ gar n tsilunin n unfafad d yiẓuran i sent-d-yezzin, ladɣa anagraw anaffal.
Izirigen imuḍinen zemren ad rewlen ɣef unagraw anaffal, d ayen i ten-yettaǧǧan ad ttimɣuren u ad ttwazerɛen war ma yettwaḥbes.
Nnig waya, amḍiq ameẓyan n tgezzayt yezmer ad yesnerni amɣi n tgezzayt d metastase s usuddes n umḍiq i tsilunin n kunsir.
Tasnudert n tdawsa n unfafad bu uεebbuḍ d tamhelt yemgaraden, dɣa imnadiyen ttkemmilen leqdic akken ad fehmen ugar timahilin yellan ddaw-as akken ad d-snulfun isufar iǧehden ugar u ad snerniwen igmaḍ n umuḍin.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
['Anfafad: amejjay']
['Asmel-a web yettunefk-d kan i yiswiyen n uselmed d usissen, ur d-yettak ara iwellihen imejjayen neɣ isefka udmawanen.']
['Isallen i d-yettunefken ur ilaq ara ad ttwasqedcen i usebded neɣ i usemḥi n kra n wugur n tezmert neɣ aṭṭan, yerna wid yettnadin ɣef yiwellihen imsujjiyen udmawanen yessefk ad ẓren amejjay yesɛan turagt.']
['Ttxil-k ẓer belli azeṭṭa amseddayan i d-yettaken tiririyin i tuttriwin, ur iṣeḥḥa ara mliḥ ma yella d ayen yerzan uḍḍun. D amedya, amḍan n yimdanen yettwaḍḍfen s kra n waṭṭan.']
['Ssutur dima ṛṛay n ṭṭbib-ik neɣ n kra n umejjay-nniḍen ara iwalmen ɣef waṭṭan-ik. Ɣur-k ad tḥeqreḍ ṛṛay n ṭṭbib amsadur neɣ ad tεeṭṭleḍ deg usuter-is ɣef lǧal n kra i teɣriḍ deg usmel-a. Ma tɣileḍ ahat tesεiḍ liḥala n tεeǧlanit deg tezmert, siwel 911 neɣ ṛuḥ ɣer texxamt n tεeǧlanit i d-iqerben. Ulac assaɣ gar ṭṭbib d umuḍin i d-yettnulfun s usmel-a neɣ aseqdec-is. BioMedLib neɣ ixeddamen-is, neɣ kra n win yettekkiyen deg usmel-a, ur d-ttaken ara yakk kra n yisumren, s wawal neɣ s usemres, ɣef ayen yerzan isallen i d-yettunefken dagi neɣ aseqdec-is.']
['Anekcum: azref n uḍfar']
['Asaḍuf n umeskar n yizerfan n wemdan n alfin (Digital Millennium Copyright Act) n 1998, 17 U.S.C. § 512 (DMCA) yettak-d ttawil i yimeskaren n yizerfan n wemdan i yumnen belli ayen i d-yettbanen deg Internet yettḍurru izerfan-nsen ddaw usaḍuf n umeskar n yizerfan n wemdan n Marikan. ']
['Ma tumneḍ s wul yelhan belli kra n taɣult neɣ taɣawsa yettwafken deg unermes-nneɣ neɣ deg yiqeddacen-nneɣ tegzem azref-ik n uḥraz, tzemreḍ (neɣ amsedday-ik) ad aɣ-d-tazneḍ izen akken ad nessuter asuffeɣ n taɣult neɣ n taɣawsa-nni, neɣ ad nessader tuqqna ɣer-s. ']
['Isental yessefk ad ttwazen s tira s yimayl (ẓer asebter "Contact" i tansa n yimayl).']
['DMCA teḥwaǧ isalli-inek n tukksa n yizerfan yettwanekṛen ad d-yeglu s yisallen-a: (1) asegzi n umahil yettwaḥerzen s yizerfan yettwanekṛen i d-yettwanekren; (2) asegzi n uḍris yettwanekren d yisallen ara aɣ-yeǧǧen ad d-naf uḍris-nni; (3) isallen n usiwel inek, ladɣa tansa-inek, uṭṭun n tilifun d tansa imayl; (4) awal sɣur-k d akken tumneḍ s wayen yelhan belli aḍris-nni s wamek i d-tettcetkiḍ ur yettwasemres ara sɣur bab n yizerfan, neɣ amesten-is, neɣ s useqdec n kra n usaḍuf; ']
['(5) yiwet n tseddi sɣur-k, yettwatten s uḥasef n lekdeb, d akken isallen yellan deg uzenzi d iṣeḥḥan u tesεiḍ azref ad tesseḍruḍ izerfan umeskar i d-yeqqaren ttwarẓen; ']
['akked (6) azmul n tfekka neɣ n tuqqna tagensit n bab n yizerfan neɣ n umdan yettwafernen ad yexdem s yisem n bab n yizerfan. ']
['Ma ur d-terriḍ ara isallen-agi akk, yezmer ad d-yeglu s uεeṭṭel deg usefrek n ucetki-inek.']
['Assaɣ']
['Ttxil-k azen-aɣ-d imayl ma tesεiḍ asteqsi / asumer.']
What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
Disclaimer: medical
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['Ɣef']
['BioMedLib yesseqdac iselkimen imseddayen (algoritmes n ulmad n tnaεurt) i usnulfu n tuqqniwin n tuttriwin d tririyin.']
['Nebda s 35 imelyan n teẓrigin n tesnujjya tameddurt n PubMed/Medline. Rnu daɣen, isebtar n web n RefinedWeb.']
