What causes Alzheimer?

Ese ni iki gitera indwara ya Alzheimer?

Indwara ya Alzheimer ni indwara y'imitsi igenda ihindagurika yibasira cyane ubwonko, igatera ibibazo byo kwibagirwa, kwangirika k'ubushobozi bwo gutekereza n'imiyoborere.

Nubwo nta wuzi neza igitera iyo ndwara, abantu batekereza ko iterwa n'ibintu bitandukanye, urugero nk'imiterere y'umubiri, aho umuntu aba n'uko abaho.

Bimwe mu bishobora gutuma umuntu arwara indwara ya Alzheimer harimo:

1. Ingirabuzima fatizo zigena uko umuntu azaba ateye: Hari ingirabuzima fatizo zimwe na zimwe zagaragajwe ko zishobora gutuma umuntu arwara indwara ya Alzheimer, cyane cyane ingirabuzima fatizo yitwa apolipoprotéine E (APOE).

2. Imyaka: Iyo umuntu ashaje, ibyago byo kurwara indwara ya Alzheimer biriyongera, kandi abenshi mu bayirwara baba barengeje imyaka 65.

3. Kuba umuntu yarigeze kurwara iyo ndwara mu muryango: Iyo umuntu yarigeze kurwara iyo ndwara mu muryango, bishobora gutuma arushaho kwibasirwa na yo.

4. Gukomereka mu mutwe: Gukomereka mu mutwe, cyane cyane mu gihe umuntu yatakaje ubwenge, bishobora gutuma umuntu arushaho kurwara indwara ya Alzheimer.

5. Ingaruka zo kurwara umutima: Indwara z'umuvuduko w'amaraso ukabije, kugira ibinure byinshi mu maraso no kurwara diyabete, bishobora gutuma umuntu arwara indwara yo kwibagirwa.

6. Imibereho: Kudakora imyitozo ngororangingo, kurya nabi no kudakora cyane bishobora gutuma umuntu arwara indwara ya Alzheimer.

7. Kuribwa mu bwonko: Kuribwa mu bwonko mu gihe kirekire bishobora gutuma umuntu arwara indwara yitwa Alzheimer.

8. Umunaniro ukabije: Iyo umubiri udashobora gukora imisemburo myinshi mu gihe umubiri uba ucyeneye kuyikuramo, bishobora gutuma umuntu arwara indwara ya Alzheimer.

9. Amapande ya amyloid na za mikorobe: Kwiyongera kwa za mikorobe mu bwonko ni ikimenyetso cy'indwara ya Alzheimer, ariko uruhare zigira mu gutuma umuntu arwara iyo ndwara ntiruzwi neza.

Ni ngombwa kumenya ko indwara ya Alzheimer iterwa n'ibintu byinshi kandi ko ishobora kuba iterwa n'ibyo bintu byombi.

Ubushakashatsi burakomeje kugira ngo hamenyekane neza imikorere y'icyo kibazo kandi haboneke uburyo bwiza bwo kugivura.

['Ibitabo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

['Icyitonderwa: ubuvuzi']

["Uru rubuga rwashyiriweho kwigisha abantu no kubaha amakuru gusa, ntirutanga inama ku birebana n'ubuvuzi cyangwa ngo rukore nk'ikigo gitanga serivisi z'ubuvuzi."]

["Amakuru atangwa n'iyi porogaramu ntagomba gukoreshwa mu gusuzuma cyangwa kuvura ikibazo cy'uburwayi cyangwa indwara runaka, kandi abashaka inama z'ubuvuzi bagombye kugisha inama umuganga ubifitiye uburenganzira."]

['Nyamuneka menya ko imbuga nkoranyambaga zitanga ibisubizo kubibazo, ntabwo zifite ukuri mugihe kijyanye numubare. Kurugero, umubare wabantu basanzwemo indwara runaka.']

["Buri gihe ujye usaba inama umuganga wawe cyangwa undi muntu wemewe mu bijyanye n'ubuzima ku bijyanye n'uburwayi. Ntuzigere wirengagiza inama z'abaganga cyangwa ngo utinde kuzisaba bitewe n'ikintu wasomye kuri uru rubuga. Niba utekereza ko ufite ikibazo cyihutirwa, hamagara 911 cyangwa ujye ku ivuriro rikwegereye. Nta mubano hagati y'umuganga n'umurwayi ukorwa n'uru rubuga cyangwa ikoreshwa ryarwo. Yaba BioMedLib cyangwa abakozi bayo, cyangwa undi muntu wese wagize uruhare kuri uru rubuga, nta gihamya batanga, yaba igaragara cyangwa itagaragara, ku bijyanye n'amakuru atangwa hano cyangwa ikoreshwa ryayo."]

["Ibirego: uburenganzira bw'umuhanzi"]

["Itegeko ryo mu 1998 ryerekeye uburenganzira bw'ibihumbi by'ibihumbi by'ibihumbi by'ibihumbi, 17 U.S.C. § 512 (DMCA) ritanga ubujurire ku bafite uburenganzira bw'umuhanzi bemera ko ibintu bigaragara kuri interineti bibangamira uburenganzira bwabo hakurikijwe amategeko y'uburenganzira bw'umuhanzi muri Amerika. "]

['Niba wemera ko ibintu cyangwa ibikoresho byashyizwe ku rubuga rwacu cyangwa serivisi bitubahiriza uburenganzira bwawe, wowe (cyangwa umuhagarariye) ushobora kutwoherereza ubutumwa udusaba ko ibyo bintu cyangwa ibikoresho bikurwaho, cyangwa ko utabikoresha.']

['Itangazo rigomba koherezwa mu nyandiko kuri interineti (reba ahanditse "Kwitaba" kugira ngo ubone aderesi ya interineti). ']

["DMCA isaba ko imenyesha ryawe ry'ikirego cyo kuvutswa uburenganzira rikubiyemo amakuru akurikira: (1) ibisobanuro by'igikorwa kirengera uburenganzira bw'umuhanzi kivugwaho kuvutswa uburenganzira; (2) ibisobanuro by'ibikubiyemo bivugwa ko ari ukurenga ku mategeko n'amakuru ahagije atuma dushobora kubona ibikubiyemo; (3) amakuru yo kuguhamagaraho, harimo aderesi yawe, nomero ya terefone na aderesi imeyiri; (4) inyandiko yawe ivuga ko ufite icyizere ko ibikubiyemo mu buryo bwatanzwe nta burenganzira bifite na nyiri uburenganzira bw'umuhanzi, cyangwa umukozi we, cyangwa mu mategeko ayo ari yo yose; "]

["(5) inyandiko yawe isinyweho, uhanishwa kubeshya, yemeza ko amakuru ari mu itangazo ari ukuri kandi ko ufite ububasha bwo kurengera uburenganzira bw'umuhanzi uvugwaho kubwamburwa; "]

["kandi (6) umukono usanzwe cyangwa wa elegitoroniki w'ufite uburenganzira ku nyandiko cyangwa uw'umuntu wabiherewe uburenganzira bwo gukora mu izina ry'ufite uburenganzira ku nyandiko. "]

['Kudatanga amakuru yose yavuzwe haruguru bishobora gutuma ikibazo cyawe gitinda gukemurwa.']

['Uko twavugana na we']

['Ohereza imeri ikibazo / igitekerezo.']

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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