What is pathophysiology of Diabetes?

['Wande ruwu adǝ fanne']

Abi shima physiology kwasa tәlibe wo?

Pathophysiology kwasuwa shiro diabetes gultində shima kəra awoa tiyi ti kamma lezənama shiro diabetes mellitus gultində.

Diabetes mellitus jami donyi kasuwa donyi suro buwu lan wajin ma, tahyiraat donyi sukari ye suro buwu lan nǝm kǝrawu lan wajin ma (glucose) shi donyi dalil insulin be luwala kǝnzǝli be awu cida insulin be awu indiso ma.

Pathophysiologydo kwasa shiwurye-a ye suronzǝn nǝmkam mbeji kate geneticya, kǝndaram kǝndaram be-a, kuru letǝgǝram kǝnǝngabe-a sandi samma so banazǝyin.

Kashi 1 diabetes mellitus lan, pathophysiologydǝ shima kǝlâ nza wuratǝbe insulin kǝndowu beta cells pancreaticbe shidoy kǝla insulinbe kǝltǝnzǝben.

Adǝye sukku donyi suro buye ngǝlaro notobe suwudin, hyperglycemia (zawur buye) ro suwudin.

Kashi 2 me, kwasuwa shiro type 2 diabetes gultin dǝ ye, shima dǝ zauro asutu kuttu kuru insulin resistance dǝga suwudin, kuru insulin secretion dǝga wuzǝyin.

Insulin resistantdə shima loktu donyi tiye də lan insulin nguwutəgə lan mbauzəyin ma, adəye səkə ta'adir glucose ye də fandatiyin ba.

Adəye səkə pancreas də insulin nguwu sutuluyin kurun dəga kaltəgəro, amma loktuwa gozəna lan, pancreas də raksə muradə dəga kaltəgəro səkinba, adəye səkə insulin sutuluyin fulutə.

Kwasa kǝli kǝli surobe (gestational diabetes) dǝ sa nǝmngǝli lan wajin, faltǝ hormonbe shima dǝ sǝkǝ insulin resistance ro suwudin.

Awo tiyi kamuye shiro placenta gultin dǝ hormone so sutuluyin, shi doni insulin dǝga kaltǝyin ma, adǝye sukari suro buye dǝga sǝrayin.

Pathophysiology kwasuwa shiro diabetes sayindəbe suron kaziyya ngəwu wajin, alamanna zawal bube-a, zar-a, kuru tiyi dabbaye-a zauyin, sandi doni kazəyiya nəlefabe kura-kura jili kwasuwa kərənbe-a, strok-a, kwasuwa kərənbe-a kuru shim bannabe-a suwudin.

Kǝrǝn kam donyi diabetesye nasha donyi physiologybe ya asutin dǝ shima kasuwa donyi kurun futǝnama be kǝlâ.

['Wutəgə']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

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What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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