De ziekte vaan Alzheimer weurt gediagnosticeerd door 'n combinatie vaan methodes, boe-oonder 'n grondige medische evaluatie, cognitieve en neuropsychologische teste, hersenafbeeldinge en 't proces vaan 't eliminere vaan aander meugeleke oorsake.
1. Medisch oonderzeuk: 'ne Dokter zal 'n lichamelek oonderzeuk doen en 'n gedetailleerde medische historie opnumme um aander meugeleke oorsake vaan geheugeverlies of cognitief verval oet te sluite, wie schildklierprobleme, vitamine-tekorte of hersentumore.
2. Cognitieve en neuropsychologische teste: Dees teste beoordeile geheuge, taol, probleemoplossing en aander cognitieve functies um de umvaank vaan cognitieve versjlechtering te bepaole en te oondersjeie tösse normaal leeftiedsverwant geheugeverlies en dementie.
3. Beeldvorming vaan de hersene: Magnetische resonantie beeldvorming (MRI) of computertomografie (CT) scans kinne helpe bij 't identificere vaan structurele veranderinge in de hersene die kinne wijze op Alzheimer.
Positronemissie tomografie (PET) scans kinne ouch gebruuk weure um de niveaus vaan bepaolde proteïne die mèt de ziekte vaan Alzheimer verband hawwe te maete.
4. Bloodtèsse: Recente oonderzeuke höbbe laote zien tot bepaolde bloodtèsse kinne helpe bij 't diagnosticere vaan Alzheimer door de niveaus vaan specifieke proteïne of biomarkers die mèt de krenkde verband hawwe te maete.
5. Proces vaan eliminatie: Umtot d'r gein einmaolege definitieve test veur de ziekte vaan Alzheimer is, behels de diagnose dèks 't oetgeslote weure vaan aander meugeleke oorsake vaan dementie-achtige symptome.
't Is belangriek te merke dat 'n definitieve diagnose vaan Alzheimer pas nao d'n doed gemaak kin weure door 'n oonderzeuk vaan hersenweefsel.
De huidige diagnostische methodes kinne evels 'n hoeg zekerheidsgraad geve veur 'n klinische diagnose terwijl de persoen nog leef is.
Vroege diagnose is belangriek veur 't beginne vaan behandeling en 't planne veur de touwkoms.
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[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.
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Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.
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How is alzheimer diagnosed?
Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.
1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.
2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.
3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.
Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.
4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.
5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.
It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.
However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.
Early diagnosis is important for starting treatment and planning for the future.
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