Dikke darmkanker, ouch wel dikke darmkanker geneump, weurt veroorzaakt door de ónbeheerste greuj van abnormale celle in de dikke darm of rectum.
De exacte oorzaak vaan darmkanker is neet bekind, mer versjèllende factore kinne 't risico op 't oontwikkele vaan de krenkde vergroete.
Dit zien:
1. Laeftied: 't Risico op darmkanker kump mèt de laeftied veur, en de mieste gevalle zien vaan lui euver de 50.
2. Familiegesjiedenis: 'n Persoonleke of familiegesjiedenis vaan darmkanker of poliepe vergroet 't risico op 't oontwikkele vaan de krenkde.
3. Erfde syndrome: Bepaolde erfde genetische syndrome, wie familiale adenomateuze polyposis (FAP) en erfeleke neet-polyposis colorectale kanker (HNPCC), kinne 't risico op dikke darmkanker vergroete.
4. Leefstijlfactoren: 'n Dieet mèt väöl roed en verwerk vleis, euvergewich, rouke en euvermatig alcoholgebruuk kin 't risico op darmkanker vergroete.
5. Inflammatoire darmziekte: Langdurige inflammatoire darmziektes, wie colitis ulcerosa en Crohn's ziekte, kinne 't risico op darmkanker vergroete.
6. Type 2 diabetes: Lui mèt type 2 diabetes höbbe 'n hoeger risico op darmkanker.
7. Bestralingstherapie: Bestralingstherapie veur aander kankers in de buik kin 't risico op darmkanker vergroete.
8. Ras: Afro-Amerikanen höbbe 'n hoeger risico op darmkanker es ander rasse.
't Is belangriek te merke dat 't höbbe vaan ein of mie vaan dees risicofactoren neet per se beteikent dat 'n persoen darmkanker zal oontwikkele, en sommege lui die darmkanker oontwikkele höbbe gein bekinde risicofactoren.
Regelmaoteg screening en vreug opsporing kinne helpe darmkanker te veurkoume of 't in 'n vreug stadium te opsporen es 't 't meiste te behanjele is.
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Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.
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What causes colon cancer?
Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.
The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.
These include:
1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.
2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.
3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.
4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.
5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.
6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.
7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.
8. Race: African Americans have a higher risk of developing colon cancer than other races.
It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.
Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.
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