L'urticaria, comunement cognossuda cuma urticaria, l"è una condizion de la pell caratterizada de l'aparizion de bruf de color ross, alzà e pruriginus in su la pell.
La fisiopatologia de l'urticaria la coinvolge el rilasciament de istamina e olter mediator inflamatori dei mastocit, qe i è cellule immunitarie qe se troeuven ind la pel e olter tessud.
Ind l'urticaria acuta, el rilasciament de istamina e olter mediator l"è scatenad de una reazion allergica a un allergen specifeg, comè el mangiar, la medesina o la puntura de insett.
Chesto al fa che i mastocit se degranulen, liberand istamina e olter mediadur che fan diventar i vas sanguigni permeabili, condusend a la formaziun de rued.
Ind l'urticaria cronica, la causa l"è despess scunusüda, ma se pensa che la sia ligada a un mecanism autoimun.
In chest cas, el corp el prodüss autoanticorp che mira al recetur IgE de alta affinità (FcεRI) in sui mastocit, che porta a la sua attivaziun e al rilasci de istamina e olter mediadur.
In de l'urticaria acuta e cronica, el rilasciament de istamina e olter mediator porta ai sintom carateristich de prurito, ros e gonfior.
El tratament de solet el coinvolge l'uso de antiistaminich per blocar i efet de l'istamina e ridur i sintom.
In di cas sever, pœden vesser drovads olter medegh cuma i corticosteroid o l'omalizumab per controllar la condizion.
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Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
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What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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