Diabetesa patofiziologeja ir pietejums par neveiklim fiziologiskim procesim, kas var izraiseit diabeta atteisteibu.
Cukura diabets ir metabolisma slimeibu grupa, kurai rakstureiga augsta cukra (glikozis) leimeņa leimeņa deļ insulina izadaleišonys, insulina darbeibys voi obeju tryukumu.
Diabeta patofiziologejā ir sarežgeita genetisku, vidis i dzeivisveida faktoru sovstarpeiga īdarbeiba, kas veicynoj slimeibys atteisteibu.
1. tipa diabeta patofiziologejā ir īkļauta insulinu ražojūšūs beta šyunu autoimūna iznycynuošona aizkuopē, kas nūvad pi insulina ražuošonys tryukuma.
Tys izraisa navīnleidzeibu ar glikozis leimini, kas rūsynoj hiperglikemeju (augstu glikozis leimiņu).
2. tipa diabeta patofiziologeja ir sarežgeituoka i ītver gon insulina rezistenci, gon ari pasamazinātu insulina sekreceju.
Insulina rezistence rūnās, kod šyunys nav adekvatys pret insulinu, leidz ar tū navar efektivi izmontuot glikozi energejis īgivei.
Tys līk padūmu dzemdeibom ražuot vaira insulina, kab puorvarātu rezistenci, tok laika gaitā padūmu dzemdeibom var nabyut vareibys uzturēt paceli pīprasejumu, kas nūvad pi insulina ražuošonys sasamazynuošonys.
Gestacejis diabets, kas rūnās gryuteibys laikā, ir īrūbežuots ar hormonalom izmaiņom, kas nūvad pi insulina rezistencis.
Placenta ražoj hormonus, kas var blokeit insulina darbeibu, kas izraisa glikozis leimiņa pasalelynuošonu.
Diabetesa patofiziologejā ir īsaisteita ari komplikceju atteisteiba, par pīmāru, ašņa, nervu i organu būjuošona, kas var izraiseit smogys veseleibys problemys, par pīmāru, sirds slimeibys, insulta, nieru slimeibys i redzis zudumu.
Diabeta patofiziologejis izpratne ir cīši svareiga, kab izstruoduotu efektivu itū hronisku slimeibu uorstiešonys i profilaksis strategeju.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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['Vysod meklejit padumu nu sova uorsta voi cyta kvalificāta uorsta, kab saprostu jiusu slimeibu. Nikod naatsakuortojit profesionalū uorsta padumu voi aizkavejit tū mekliešonu deļtuo, ka esat koč kū izlasiejs itamā interneta vītnē. Ka jiusim ruodīs, ka jiusim var byut uorsteibys uorkuortys situaceja, zvaniet 911 voi īīt tyvuokajā uorstnīceibys centrā.']
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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