What is pathophysiology of Heart attack?

Wuliriza olupapula luno

Pathophysiology y'obulwadde bw'omutima y'eruwa?

Obulwadde bw'omutima, era obumanyiddwa nga myocardial infarction, buzingiramu okukosebwa kw'omusaayi mu kitundu ky'omubiri gw'omutima, ekiviirako obutoffaali bw'omutima okufa.

Kino kitera okubaawo olw'okuziba kw'omukka oguyitibwa coronary artery olw'omusaayi oguyitibwa blood clot, oguyitibwa atherosclerosis, embeera ey'okukuŋŋaanyizibwa kw'amawuggwe mu mmunyeenye.

Ekiwundu kino kirimu cholesterol, amasavu, ebintu ebiva mu butoffaali, calcium, ne fibrin.

Ensigo bw'emenyeka, esobola okuleetawo omusaayi oguyinza okuziba omubiri, oguyinza okuziba omubiri n'okulemesa omusaayi ogulina omukka ogujjudde omukka okutuuka mu mutima.

Obutaba na oxygen buno buviirako obutoffaali bw'omubiri gw'omutima okufa, ne buviirako obulwadde bw'omutima.

Obunene bw'obuvune bwesigamye ku bunene bw'ekitundu ekiteekebwateekebwa omubiri n'ebiseera ebiri wakati w'obulwadde n'obujjanjabi.

Obubonero bw'obulwadde bw'omutima buyinza okuzingiramu obulumi mu kifuba oba obutaba bulungi, okufuuyira, okukaaba, okweraliikirira, n'obulumi mu mikono, mu bulago, mu nsingo, oba mu mugongo.

Obujjanjabi bw'obulwadde bw'omutima butera kuzingiramu okuzzaawo omusaayi mu mubiri amangu ddala nga bwe kisoboka, nga bakozesa eddagala oba enkola nga angioplasty ne stenting oba coronary artery bypass surgery.

Kikulu okukijjukira nti obulwadde bw'omutima bukalu nnyo era butwaliramu ebintu bingi, nga mw'otwalidde ebintu eby'ekinnansi, engeri y'obulamu, n'embeera y'obutonde.

Ebintu ebiyinza okuleetera omuntu okufuna obulwadde bw'omutima mwe muli obulwadde bw'omusaayi obw'amaanyi, cholesterol ey'amaanyi, okunywa sigala, sukaali, okwegulumiza, obutakola dduyiro, n'okuba n'obulwadde bw'omutima mu maka.

Okufuga ebintu bino ebireeta akabi kuyinza okukuyamba okukendeeza ku busobozi bw'okufuna obulwadde bw'omutima.

Ebikwata ku bantu

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Scott J: Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004, 14 (3): 271-9.

Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .

Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.

LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.

Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.

Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.

Okwewala obuvunaanyizibwa: eby'obujjanjabi

Omukutu guno guweereddwa olw'ebigendererwa by'enjigiriza n'obubaka bwokka era teguwa kubuulirira kw'ekisawo oba obuweereza bw'ekikugu.

Obubaka obuweereddwa tebusaanidde kukozesebwa okuzuula oba okujjanjaba bulwadde, era abo abanoonya amagezi g'ekisawo balina okwebuuza ku musawo alina layisensi.

Weetegereze nti enkola ya neural net ekola eby'okuddamu mu bibuuzo, si ntuufu nnyo bwe kituuka ku muwendo gw'abantu. Ng'ekyokulabirako, omuwendo gw'abantu abalwadde obulwadde obumu.

Bulijjo noonya amagezi g'omusawo wo oba omusawo omulala omutuufu ku bikwata ku mbeera y'obulamu. Teweerabira magezi g'omusawo oba okulwawo okuganoonya olw'ekintu ky'osomye ku mukutu guno. Bw'oba olowooza oyinza okuba n'embeera ey'amangu mu by'obulamu, yita 911 oba genda mu ddwaaliro ly'amangu erisinga okumpi amangu ddala. Tewali nkolagana ya musawo n'omulwadde ekolebwa ku mukutu guno oba okukozesawo. BioMedLib oba abakozi baagwo, oba omuntu yenna ayamba ku mukutu guno, talina ky'agamba, ekyogamba oba ekiteeberezebwa, ku bikwata ku bubaka obuli wano oba okukozesawo.

Okwewala obuvunaanyizibwa: eddembe ly'okuwandiika

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What is pathophysiology of heart attack?

The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.

This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.

The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.

When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.

This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.

The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.

Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.

Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.

It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.

Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.

Managing these risk factors can help reduce the likelihood of experiencing a heart attack.

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