Pathophysiology mar kansa mar thuno wuoyo kuom lokruok ma ok kare matimore e yore mapile mag ngima kod yore matimore e dongruok kod dongruok mar kansa mar thuno.
Tiyo gi yorni oriwo nono gik matimore e dend ng'ato kod gik matimore e ng'ato ma miyo ng'injo mag kansa dongo kendo landore e dend ng'ato.
Mano oriwo gik manyalo miyo ng'ato obed gi tuwo mar kansa mar thuno, gik manyalo miyo ng'ato obed gi tuwo mar kansa mar thuno, kod gik manyalo miyo tuwo mar kansa mar thuno omedre.
Moko kuom lokruoge madongo mag pathophysiological e kansa mar thuno oriwo:
1. Lokruok mag anyuola: Lokruok mag anyuola moko, kaka BRCA1 kod BRCA2, nyalo miyo ng'ato obed gi tuwo mar kansa mar thuno.
Lokruok ma kamago nyalo bedo mar anyuola kata nyalo bedoe e ngima ng'ato.
2. Chwanyruok mar hormone: Hormone, to moloyo estrogen, nyalo konyo e miyo kansa mar thuno ochakre kendo dongo.
Bedo gi hormone mang'eny maok owinjore kata bedo gi estrogen mang'eny nyalo miyo ng'ato obed gi tuwo mar kansa mar thuno.
3. Ywak: Ywak mosiko e ofuko mar thuno nyalo miyo ng'ato obed gi tuwo mar kansa mar thuno kuom miyo ng'injo mag kansa omed dongo kendo bedo mangima.
4. Kuonde ma tuwo mar kansa yudoree: Kuonde ma tuwo mar kansa yudoree, moriwo nyaka kuonde ma tuwo mar kansa yudoree, ng'injo mag geng'o tuoche, kod ng'injo mag remo, nyalo miyo tuwo mar kansa mar thuno omed dongo kendo landore.
5. Metastasis: Tuwo mar kansa mar thuno nyalo landore e fuonde mamoko mag del kokalo kuom lymphatic system kata remo, kendo mano nyalo miyo ng'ato obed gi tuwo mar secondary tumor e fuonde mamoko mag del.
Ng'eyo kaka tuwo mar kansa mar thuno chalo en gima duong' ahinya e loso yore mag geng'o tuwono, fwenyo tuwono chon, kod thiedhe.
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Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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Chiegni ni
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