How is Alzheimer diagnosed?

['Kelg-y seb-kãngã']

Wãn to la b bãngd bãagã?

B sẽn maand to-to n bãng bãagã yaa toor-toore. Wala makre, logtorã vaeesda bãagã sõma, n maand vaeesg sẽn na yɩl n bãng bãagã sẽn namsd ned to-to, n get a yĩngã, a yamã, la a sẽn tõe n maan bũmb ning n bãng bãagã sã n sɩd tara pãnga.

1. Logtorã vaeesgo: Logtorã na n vaeesa bãadã, n bao n bãng a bãagã sẽn sɩng to-to, sẽn na yɩl n bãng bũmb a taab sẽn tõe n wa ne a yĩn-sidgã kaalem, wala makre, a sã n pa tar yĩn-wɩsgrã, a sã n pa tar vitamin-rãmb wʋsgo, bɩ a sã n tara kalkõtã.

2. Bãngrã la yam-tagsgã vaeesgo: B vaeesda ned pʋ-tẽerã, a sẽn tõe n gom to-to wã, a sẽn tõe n welg zu-loees to-to wã, la a yam-tagsgã yɛl a taab sẽn na yɩl n bãng a sã n pa le tõe n tags sõma, la a sã n pa le tõe n tẽegd yɛl wʋsg a kʋʋlem wakate.

3. Masĩn dãmb sẽn maand n get ninsaal kalkõtã: Masĩn dãmb sẽn maand tɩ ninsaal kalkõtã tar pãng n tõe n yã bũmb nins sẽn kɩt tɩ bãagã beẽ wã.

B tõe n tũnuga ne masĩn a to me n mag porotɛn dãmb kẽer sẽn tar pãng wʋsg bãagã pʋgẽ.

4. Zɩɩm vaeesgo: Vaeesg b sẽn maan sẽn pa kaoos wilgame tɩ zɩɩm vaeesg kẽer tõe n sõnga ne bãagã bãngre, b sã n mag porotɛn dãmb takɩ bɩ bõn-kɩds sẽn wilgd bãagã sẽn wat ne yɛl ninsã.

5. B sẽn pa tõe n bãng bãagã sẽn wat ne bũmb ninsã: Sẽn mik tɩ bãagã tɩɩm yaa toor fasɩ wã yĩnga, naoor wʋsgo, b sã n na n bãng bãagã sẽn wat ne bũmb ninsã, b segd n bao n bãnga bũmb a taab sẽn tõe n wa ne bãagã.

Yaa tɩlae tɩ d bãng tɩ yaa ned kũum poor bal la b tõe n bãng bãagã sã n sɩd yaa a Alzeimeer bãaga.

La logtoeemdã sẽn maand to-to rũndã-rũndã wã tõe n kɩtame tɩ b bãng bãagã sã n sɩd tara ned a to, a soabã sã n ket n vɩ.

B sã n bãng bãagã sẽn sɩngd wakat ningã, yaa tɩlae tɩ b sɩng tɩbsg la b maan magb beoog yĩnga.

['Sõss sẽn tik Biiblã zugu']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

['Bãngr-gomde: logtoeemdã']

['Yaa zãmsg la kibay kũun yĩng bal la b yiisd sit kãngã, la pa logtoeemdã wɛɛngẽ sagls bɩ tʋʋm-sõng maaneg yĩng ye.']

['B pa segd n tũnug ne kɩbay nins b sẽn kõ wã n bao bãag bɩ zu-loɛɛg tɩɩm ye. Sẽn dat-b tɩbsg b toor segd n tɩ yãa logtor sẽn tar sor n tõe n tɩp-ba.']

['D tẽeg tɩ b sẽn maand to-to n leokd sogsgã to-to wã pa zems ye.']

['Y sã n wa karemd bũmb sẽn be sɩtã pʋgẽ, bɩ y ra tol n yĩm tɩ y segd n tɩ gesa logtor ye. Y sã n tagsdẽ tɩ y tara yĩn-wɩsgr yell bɩ y bool 911 wall y kẽng logtor yirã.']

['Bas-m-yam: sɛbã zãab wɛɛngẽ']

['Digital Millennium Copyright Act sẽn yaa yʋʋmd 1998 soabã, 17 U.S.C. § 512 (DMCA) kõta sor tɩ ned sã n tẽed tɩ bũmb sẽn be ẽntɛrnetã pʋgẽ kɩɩsda a sẽn tar sor n tõe n maan bũmb ninsã, a tõe n tɩ kos n paam n lebse.']

['Yãmb sã n tẽed ne pʋ-peelem tɩ bũmb sẽn be tõnd sɩt wɛɛbã pʋgẽ bɩ tõnd tʋʋm-noyã pʋsẽ n sãamd yãmb dʋrwa wã, yãmb (bɩ y tʋʋm-tʋmdã) tõe n toola tõnd koɛɛg n kos tɩ d yiis bũmbã wall d gɩdg tɩ y ra paam n kẽ ye.']

['B segd n tʋma koees ne ẽtɛrnetã (Ges-y ẽtɛrnetã adɛrs sẽn be babg ning sẽn yet tɩ "Tõnd sõsg zĩigã").']

['DMCA wã baoodame tɩ yãmb sẽn na n togs ned tɩ b maan-a-la bũmb sẽn kɩɩsd a sẽn tar sor n tõe n maan bũmb ningã, bɩ y wilg-a bũmb nins sẽn pʋgdã: 1) bũmb ning sẽn kɩt tɩ b maan-a bũmb ningã, 2) bũmb ning sẽn kɩt tɩ b maan-a bũmb ningã, la y wilg-d bũmb ning sẽn kɩt tɩ d tõe n bãng a sẽn be zĩig ninga. 3) y sẽn tõe n paam ned n gom ne-a to-to, n paas y adɛrsã, telefõnnã nimero, la y e-mailã. 4) y sã n yeel tɩ y kɩsa sɩd tɩ bũmb ning sẽn kɩt tɩ y maan bũmb ningã pa ned ning sẽn tar sor n tõe n maan bũmbã, bɩ a tʋm-tʋmdã, bɩ laloa wã sẽn kõ sor tɩ y maan ye.']

['5) Y sã n wa rat n wilg tɩ y pa tar sor n na n kɩɩs ned a to, bɩ y gʋls sebr n wilg tɩ y sẽn togsã yaa sɩda, la tɩ y tara sor n na n wilg tɩ nedã sẽn maan bũmb ning n kɩɩs yãmb dʋrwa rãmbã yaa sɩda.']

['La (6) sɛb nins sẽn tar-b sor n na n yiis sɛbã, bɩ ned sẽn tar sor n na n tʋm sɛbã yiisg yĩngã.']

['Y sã n pa gʋls kibay nins sẽn be yĩngrã, tõe n kɩtame tɩ y yẽgengã kaoos n pa sa ye.']

['Sõsg ne neda']

['Y sã n tar sokr bɩ y sẽn dat n bãnge, bɩ y gʋls-d lɛtr n tool-do.']

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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