Pathophysiology ya tlhaselo ya pelo, yeo gape e tsebjago e le go hwa ga pelo, e akaretša go šitišwa ga tšhelo ya madi karolong ya lešika la pelo, e lego seo se lebišago lehung la disele tša pelo.
Se gantši se direga ka baka la go thibana ga tšhika ya kgokgotso ya madi, yeo gantši e bakwago ke atherosclerosis, boemo bjoo go bjona plaque e kgobokanago ditšhikeng.
Plaque e bopša ke cholesterol, dilo tše di nago le makhura, ditšweletšwa tša ditšhila tša disele, calcium le fibrin.
Ge plaka e phatloga, e ka baka gore go be le madi ao a kgobokanago, ao a ka thibago tšhika gomme a thibela madi ao a humilego ka oksitšene gore a se fihle mošifeng wa pelo.
Go hloka ga yona oksitšene mo go dira gore disele tša mešifa ya pelo di hwe, e lego seo se feleletšago ka go hlaselwa ke pelo.
Bogolo bja tshenyo bo ithekgile ka bogolo bja lefelo leo le fepšago ke tšhika yeo e thibetšwego le nako yeo e fetilego magareng ga tlhaselo le kalafo.
Dika tša tlhaselo ya pelo di ka akaretša bohloko goba go se iketle sehubeng, go hema ka pela, go feroga dibete, go ba le dihlong le bohloko matsogong, molaleng, lerameng goba mokokotlong.
Kalafo ya tlhaselo ya pelo gantši e akaretša go bušetša madi go ya mošifeng wa pelo kapejana ka mo go kgonegago, e ka ba ka dihlare goba mekgwa e bjalo ka angioplasty le stenting goba go buiwa ga ditšhika tša pelo.
Go bohlokwa go lemoga gore pathophysiology ya tlhaselo ya pelo e raragane gomme e akaretša dilo tše dintši, go akaretša tša leabela, mokgwa wa bophelo le dilo tša tikologo.
Dilo tšeo di ka bakago bolwetši bja pelo di akaretša kgateletšego e phagamego ya madi, cholesterol e phagamego, go kgoga, bolwetši bja swikiri, go nona kudu, go se itšhidulle le ge e ba go na le motho wa lapa yo a nago le bolwetši bja pelo.
Go laola dilo tše tša kotsi go ka thuša go fokotša kgonagalo ya go hlaselwa ke bolwetši bja pelo.
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LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.
Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.
Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.
['Boikano: bja tša kalafo']
['Wepesaete ye e neetšwe feela bakeng sa go ruta le go nea tsebišo gomme ga e nee keletšo ya tša kalafo goba ditirelo tša tša kalafo.']
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['(5) setatamente sa gago, seo se saennwego ka tlase ga kotlo ya go bolela maaka, gore tshedimošo yeo e lego tsebišong e nepagetše le gore o na le maatla a go phethagatša ditokelo tša mongwadi tšeo go thwego di a gatakelwa; ']
['le (6) tshaeno ya kgonthe goba ya elektroniki ya mong wa tokelo ya ngwalollo goba motho yo a dumeletšwego go dira legatong la mong wa tokelo ya ngwalollo. ']
['Go palelwa ke go akaretša tshedimošo ka moka ya ka godimo go ka dira gore go šongwa ga ngongorego ya gago go diege.']
['Go Ikgokaganya']
['Re romele imeile ka kgopelo le ge e le efe goba tšhišinyo.']
What is pathophysiology of heart attack?
The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.
This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.
The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.
When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.
This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.
The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.
Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.
Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.
It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.
Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.
Managing these risk factors can help reduce the likelihood of experiencing a heart attack.
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