What is pathophysiology of Breast cancer?

['Liɛŋ wargak ɛmɛ']

Ɛŋu mi̱ la pathophysiology duŋ kancer thuɔp?

Pathophysiology duŋ thuɔm kancer lotdɛ ni̱ gɛɛr mi̱ /ci̱ rɔ lot rɛy la̱t pua̱a̱ny ran kɛnɛ ta̱a̱ in lät kɛ min ci̱ tuɔɔk rɛy pi̱e̱thä kɛnɛ räth thuɔm kancer.

Jɛn matdɛ ŋi̱i̱c kɛ kui̱i̱ baölöji̱kal kɛnɛ möli̱köli̱kal tin la nööŋkɛ pieth mi̱ /ca luäŋ kɛ ga̱ŋ kɛnɛ däk thëlli̱ kanthɛrö rɛy pua̱a̱ny.

Nɛmɛ matdɛ ji̱i̱n, epigenetic, kɛnɛ gua̱th in cieŋ raan thi̱n tin luäk kɛ tuk, jak, kɛnɛ räth kä kancer thuɔp.

Tha̱a̱ŋ kä tin di̱t kä pathophysiölöji̱kal min gɛɛr rɔ rɛy kancer thuɔpni̱ cu määni̱:

1. Gɛni̱ tin /ca rɔ̱ lot: Gɛni̱ tin /ca rɔ̱ lot rɛy ji̱i̱ni̱ tin ciee BRCA1 kɛnɛ BRCA2, de kɛn riɛk in bi̱ tuɔk kä kanthɛr thith rep.

Kɛn mutɛciɔni̱ ti̱ti̱ dëë kɛ jek ɛ raan kiɛ dëë kɛ jek kɛ gua̱a̱th teekä ran.

2. Ɣɔrmɔɔnni̱ tin /ci̱ rɔ̱ lot: Ɣɔrmɔɔnni̱, ɛlɔ̱ŋ ɛ ɣi̱thtöri̱jen, de̱e̱ kɛ luäk kɛ kui̱i̱ kä ɣöö bi̱ kanthɛr thuɔk.

Mi̱ /ci̱ ɣɔrmɔni̱ rɔ̱ lot kiɛ mi̱ ci̱ rɔ̱ lot kɛ ɣöthtröji̱n ɛlɔ̱ŋ derɛ rɔ rep kɛ ɣöö bi̱ raan tekɛ kanthɛr.

3. Kɛn jua̱th tin laa tä kɛ jua̱th rɛy puɔ̱ny ran laa jakɛ tuɔm kä kanthɛr kɛ ɣöö laa jakɛ thëlli̱ kanthɛr kä laa pith.

4. Tumör mi̱ tɔt: Kä gua̱a̱th in te rɛy tumörä, amäni̱ min te raar thëllular matrik, thëlli̱ tin gaŋ rɔ̱ kä jua̱th, kɛnɛ riɛm, derɛ pieth kɛnɛ däk kä kanthɛr thith luäŋ.

5. Metathathith: Kɛnthɛr in te rɛy thuɔp derɛ wä rɛy pua̱a̱ny ran kɛ duɔ̱ɔ̱p mi̱ cie lymphatic kiɛ riɛm, kä derɛ nööŋ ni̱ tuɔmni̱ ti̱ dɔ̱ŋ rɛy pua̱a̱ny ran.

Ŋäc kɛ ta̱a̱ in tä pua̱a̱ny ran kɛ juey thuɔkdɛ ɛ mi̱ di̱i̱t ɛlɔ̱ŋ kɛ kui̱ kä ɣöö ba luäk mi̱ gɔaa jek, kɛ ɣöö ba jɛ jek kɛ gua̱a̱thdɛ, kɛnɛ ɣöö ba jɛ luäk.

['Kuënɛ']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.

Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.

Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.

Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.

Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.

['Lät kɛ kui̱i̱ jua̱thni̱']

['Ɛn wɛbthaay ɛmɛ ca la̱th lät kɛ kui̱ ŋi̱i̱cä kɛnɛ läri kä /cɛ lot ni ɣöö ba ji̱ moc kɛ luäk ki̱mä kiɛ lät ti̱ gööl.']

['Lät kɛ läri tin ca ŋun /ca kɛ bi̱ lät kɛ ɣöö ba jua̱th jek kiɛ ba kɛ ciɛŋ, kä nɛy tin görkɛ luäk ki̱mädiɛn kärɔ̱ ba kɛ thiec kä ki̱m mi̱ tekɛ luäk ki̱mä.']

['Guic ɛ gɔaa ɛn ɣöö ɛn neural net min jak luɔc kä thie̱cni̱, /cɛ thuɔ̱k ɛlɔ̱ŋ mi̱ ci̱ ben kä nämbäri̱ tin te thi̱n. cetkɛ pek nath tin ca jek kɛ juey mi̱ rɛlrɔ.']

['Ni ciaŋ go̱ri ruac kä ki̱mdu kiɛ ram in kɔ̱ŋ mi ŋäc luäk pua̱a̱ny kɛ kui̱ jua̱thdu. /Cu ruac ki̱mdu car kiɛ jääny kɛ go̱ri kɛ kui̱ kä mi ci kuɛn kä wɛbthaay ɛmɛ. Mi caari jɛ ɛn ɣöö deri tekɛ juey mi go̱o̱ri luäk, cɔl 911 kiɛ wër guäth in thia̱k kɛ ji kɛ pɛ̈th. /Thilɛ maar kam ki̱m kɛnɛ juey mi bi̱ tuɔɔk kɛ kui̱ kä wɛbthaay ɛmɛ kiɛ la̱tdɛ. /Ci̱ BioMedLib kiɛ la̱a̱tkɛ, kiɛ ram in gɔ̱a̱r kɛ kui̱ kä wɛbthaay ɛmɛ, bi̱ ruac lat, kiɛ bi̱ ruac lat, kɛ kui̱ läri tin ca ka̱m raar rɛydɛ kiɛ la̱tdɛ.']

['Lät kɛ: ŋuɔ̱t']

['Ɛn Digital Millennium Copyright Act 1998, 17 U.S.C. § 512 (ɛ DMCA) ɛ ŋuɔ̱t mi̱ ŋun ji̱ cuŋni̱ tin ŋääth kɛn ɣöö ci̱ ŋɔaani̱ tin te kä intɛrnɛt ŋuɔ̱tkiɛn to̱l kɛ kui̱ ŋuɔ̱tni̱ cuŋni̱ tin te kä U.S.']

['Mi ca ji̱ ŋäth kɛ thuɔ̱k ɛn ɣöö tëëkɛ mi̱ ca gɔ̱r kiɛ mi̱ ca ka̱m ji̱ rɛy wɛbthaayäda kiɛ lät tin kɔ̱ŋ tin ci̱ ŋuɔ̱t tin ca gɔ̱r ya̱r, ji̱n (kiɛ ram in lät kɛ kui̱du) deri̱ kɔ jäk kä warɛgak mi̱ bi̱ ji̱ thiec ɛn ɣöö ba min ca gɔ̱r kiɛ min ca gɔ̱r woc, kiɛ ba duɔ̱ɔ̱r la̱t kɛ ɣöö bi̱ ji̱ cop thi̱n.']

['Kɛn läri̱ ba kɛ jäk kɛ wargak ɛ la i̱thtäm (guic ni̱ gua̱th in ci̱ i̱thtäm in ca gɔ̱r "Kɔntak" kɛ kui̱ i̱thtäm in ci̱ jäk).']

['DMCA go̱o̱rɛ ɣöö bi̱ ji̱n warɛgakdu lat kɛ kui̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä mat thi̱n kɛ läär ti̱ti̱: (1) latdɛ kɛ kui̱i̱ la̱t in ca gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä min ca lar i̱ ca gɛr; (2) latdɛ kɛ kui̱i̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛnɛ läär ti̱ ro̱ŋ kɛ ɣöö bi̱ kɔn kɛ jek; (3) läri̱ kɛ kui̱i̱ kä min dëë ji̱ luäk kɛ jek, amäni̱ ci̱ötdu, nämbärɛ kä tin ci̱ ji̱ luäk kɛ jek, kɛnɛ emaildu; (4) latdu kɛ ɣöö ci̱ ji̱n ɛ ŋa̱c ɛn ɣöö min ca gɔ̱r kɛ kui̱i̱ kä tin ca lar /ci̱kɛ bi̱ lät kɛ luäkdɛ ɛ gua̱n ŋuɔ̱tni̱ gɔ̱rä, kiɛ ɛ la̱tdɛ, kiɛ kɛ luäk ŋuɔ̱tni̱; ']

['(5) mi ci ji gɔr piny kɛ kuic kä ɣöö bi ji ruac kɛ thuɔ̱k, ɛn ɣöö läri tin ca gɔr ɛ thuɔ̱k kä te ji kɛ lua̱ŋ kɛ ɣöö bi yiöw tin ca gɔr piny tin ca lar ɛ ji̱n ka̱m raar;']

['kɛnɛ (6) mi̱ ca gɔ̱r piny ɛ gua̱n ŋuɔ̱tni̱ kiɛ ram mi̱ tekɛ lua̱ŋ kɛ lät kɛ kui̱dɛ.']

['Mi /kenɛ läri tin ca lat nhial diaal mat thi̱n dɔ̱ŋ derɛ ku lɛ wɔ̱ jɔ̱ɔ̱r kɛ lätni̱ kɛ kɛ.']

['Röm kɛ jɛ']

['Thiecɛ kɔ kɛ email kɛ thiecni kiɛ cär.']

What is pathophysiology of breast cancer?

Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.

It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.

This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.

Some of the key pathophysiological changes in breast cancer include:

1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.

These mutations can be inherited or acquired during a person's lifetime.

2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.

An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.

3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.

4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.

5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.

Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.

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