E malesa di Alzheimer ta wordo diagnostica a traves di un combinacion di metodo, incluyendo un evaluacion medico completo, testnan cognitivo y neuropsicologico, imagen di cerebro, y e proceso di eliminacion di otro posibel causanan.
1. Un evaluashon médiko: Un dòkter lo hasi un eksamen físiko i tuma un historia médiko detayá pa saka afó otro posibel kousa di pèrdida di memoria òf deterioro kognitivo, manera problema di tiroides, falta di vitamina òf tumor cerebral.
2. Testnan kognitivo i neuropsikológiko: E testnan aki ta evaluá memoria, idioma, solushon di problema i otro funshonnan kognitivo pa determiná e grado di deterioro kognitivo i pa hasi un diferensia entre pèrdida di memoria normal relashoná ku edat i demensia.
3. Imaging di serebro: Magnetic resonance imaging (MRI) of computed tomography (CT) scans por yuda identifica cambionan structural den e serebro cu por indica Alzheimer.
Tambe por usa tomografia di emishon di positron (PET) pa midi e nivel di sierto proteina ku ta asosiá ku Alzheimer.
4. Análisis di sanger: Investigashon resien a mustra ku sierto análisis di sanger por yuda diagnostiká Alzheimer dor di midi e nivel di proteina spesífiko òf biomarkernan ku ta asosiá ku e malesa.
5. E proseso di eliminashon: Komo ku no tin un prueba definitivo pa Alzheimer, hopi biaha ta ekskluí otro posibel kousa di síntoma di demensia.
Ta importante pa nota ku un diagnóstiko definitivo di Alzheimer por wòrdu hasí solamente despues di morto dor di un eksamen di e tehido di serebro.
Sinembargo, e métodonan di diagnóstiko aktual por duna un nivel haltu di siguridat pa un diagnóstiko klíniko miéntras e persona ta na bida ainda.
Diagnostico tempran ta importante pa por cuminsa tratamento y plania pa futuro.
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Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.
Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.
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How is alzheimer diagnosed?
Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.
1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.
2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.
3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.
Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.
4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.
5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.
It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.
However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.
Early diagnosis is important for starting treatment and planning for the future.
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