Alzheimer ta un malesa neurodegenerativo progresivo ku ta afektá prinsipalmente e serebro, kousa pèrdida di memoria, deterioro kognitivo i kambio di komportashon.
No ta konosí kiko presis ta kousa Alzheimer, pero ta kere ku ta un kombinashon di faktornan genétiko, ambiental i estilo di bida.
Algun di e faktornan ku por kontribuí na desaroyo di Alzheimer ta:
1. Genétika: A identifiká sierto gen ku ta oumentá e riesgo di desaroyá Alzheimer, spesialmente e gen apolipoproteina E (APOE).
2. Edat: E riesgo di haña Alzheimer ta oumentá ku edat, i mayoria hende ta haña e malesa despues di 65 aña.
3. Historia familiar: Si un hende di bo famia tin Alzheimer, e riesgo pa bo tambe haña e malesa ta mas grandi.
4. Heridanan na kabes: Si bo a yega di sufri heridanan na kabes, spesialmente esnan ku ta pone bo pèrdè konsiensia, bo por haña Alzheimer.
5. Faktornan di riesgo pa desaroyá malesa di kurason: Kondishonnan manera preshon haltu, kolesteròl haltu i diabétis por oumentá e riesgo di desaroyá Alzheimer.
6. Estilo di bida: Un estilo di bida sedentario, mal alimentashon i falta di aktividat mental por oumentá e riesgo di Alzheimer.
7. Inflamacion: Inflamacion cronico den e celebro por contribui na desaroyo di Alzheimer.
8. Strès oksidativo: Un desbalanse entre e produkshon di radikalnan liber i e abilidat di e kurpa pa desintoxiká nan por kontribuí na desaroyo di Alzheimer.
9. Placa di amiloide i konekshon di neurofibrilario: E akumulashon di plaka di amiloide i konekshon di neurofibrilario den e serebro ta un señal di Alzheimer, pero no ta kompletamente komprondé e ròl ku nan ta hunga den desaroyo di e malesa.
Ta importante pa nota ku e kousa di Alzheimer ta kompliká i probablemente ta enbolbí un kombinashon di e faktornan aki.
Investigashon ta andando pa komprondé mihó e mekanismo ku ta pone e malesa aki bou di kontròl i pa desaroyá tratamentunan efektivo pa e malesa aki.
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Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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