Inona ny fisiopatolojian'ny homamiadan'ny prostate?
Ny fisiopatolojian'ny homamiadan'ny prostate dia manondro ireo rafitra sy dingana fototra izay mitarika amin'ny fivoarana sy ny fivoaran'ny aretina.
Ny homamiadan'ny prostate dia fivontosana ratsy izay mipoitra avy amin'ny sela ao amin'ny fihary prostate, izay taova kely miendrika voanjo eo ambanin'ny fivavian'ny lehilahy.
Mamoaka tsiranoka misy tsirinaina ny prostate, ary io tsiranoka io no mamelona sy mitondra ny tsirinaina.
Tsy fantatra tsara ny tena mahatonga ny homamiadan'ny prostate, nefa fantatra fa misy antony maromaro mety hampitombo ny mety hahatonga an'ilay aretina.
Anisan'izany ny taona, ny tantaram-pianakaviana, ny firazanana, ary ny fiovan'ny fototarazo sasany.
Ny homamiadan'ny prostate dia mahazatra kokoa amin'ny lehilahy antitra, ary ny ankamaroan'ny tranga dia mitranga amin'ny lehilahy mihoatra ny 65 taona.
Mety ho voan'ny kanseran'ny prostate koa ny lehilahy manana fianakaviana voan'izy io, toy ny lehilahy afrikanina-amerikanina sy taranaka avy any Karaiba.
Ny pathophysiology ny homamiadan'ny prostate dia ahitana ny fitomboana tsy voafehy sy ny fizarazaran'ny sela ao anatin'ny fihary prostate.
Mety ho vokatry ny fiovan'ny fototarazo izay miteraka fitomboana be loatra na tsy fiasan'ny fototarazo mpampitsahatra fivontosana izany.
Mety hiteraka fivontosana ny fitomboan'ny sela, noho ireo fiovana ireo.
Rehefa mihalehibe ny fivontosana, dia mety hiditra amin'ny taova sy taova manodidina, toy ny fivaviana, ny rectum, ary ny lymph node akaiky.
Amin'ny tranga sasany, afaka misaraka amin'ny fivontosana voalohany ny sela homamiadana ary miparitaka any amin'ny faritra hafa amin'ny vatana amin'ny alàlan'ny lalan-dra na ny rafi-pitatitra lymphatic, dingana iray fantatra amin'ny hoe metastasis.
Rehefa miparitaka ny kansera, dia sarotra kokoa ny mitsabo azy.
Mety hisy vokany eo amin'ny homamiadan'ny prostate koa ny hormonina, indrindra fa ny testosterone.
Mety handrisika ny fitomboan'ny sela homamiadan'ny prostate ny testosterone, ary mikendry ny hampihena ny fatran'io hormonina io na hanakana ny vokany ny fitsaboana maro atao amin'ny homamiadan'ny prostate.
Raha fintinina, ny pathophysiology ny homamiadan'ny prostate dia ahitana ny fitomboana tsy voafehy sy ny fizarazaran'ny sela ao anatin'ny fihary prostate, izay mety ho voatariky ny fototarazo, ny hormonina ary ny tontolo iainana.
Tena ilaina ny mahatakatra ny fototry ny aretina mba hahafahana mamorona fitsaboana mahomby sy hanatsarana ny fahasalaman'ny mararin'ny homamiadan'ny prostate.
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Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
['Fialana andraikitra: fitsaboana']
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['Fifandraisana']
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What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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