Pathophysiology of diabetes waxaa loola jeedaa daraasadda geeddi-socodka jir ahaaneed ee aan habooneyn ee keena horumarinta sonkorowga.
Diabetes mellitus waa koox cudurro dheef-shiid kiimikaad ah oo lagu garto heerarka sare ee sonkorta dhiigga (glucose) oo ka dhalata cilladaha dheecaanka insulin, ficilka insulin, ama labadaba.
Cudurka sonkorowga wuxuu ku lug leeyahay isdhexgalka adag ee hiddo-wadaha, deegaanka, iyo qaab nololeedka kuwaas oo gacan ka geysta horumarinta cudurka.
Cudurka macaanka ee nooca 1aad, pathophysiology wuxuu ku lug leeyahay burburinta autoimmune ee unugyada beta ee soo saara insulin ee pancreas, taasoo keenta yaraanta wax soo saarka insulin.
Tani waxay keentaa awood la'aanta in la xakameeyo heerarka gulukooska dhiigga, taasoo keenta hyperglycemia (sulphur dhiig oo sarreeya).
Cudurka macaanka ee nooca 2aad, pathophysiology-ku waa mid aad u adag wuxuuna ku lug leeyahay iska caabinta insulin iyo xakamaynta dheecaanka insulin.
Caabbinta insulinku waxay dhacdaa marka unugyada jidhku aysan si sax ah uga jawaabin insulin, taasoo keenta awood la'aanta inay si wax ku ool ah u isticmaalaan gulukooska tamarta.
Tani waxay keentaa in sambabka uu soo saaro insulin badan si uu isku dayo in uu ka gudbo iska caabinta, laakiin waqti ka dib, sambabka ayaa laga yaabaa inuusan awoodin in uu la socdo baahida, taasoo keenta hoos u dhaca wax soo saarka insulin.
Sonkorowga uurka, oo dhaca inta lagu jiro uurka, waxaa sababa isbeddelada hormoonka ee keena difaac la'aanta insulin.
Placenta waxay soo saartaa hormoonno xakameyn kara waxqabadka insulin, taasoo keenta kororka heerarka gulukooska dhiigga.
Cudurka sonkorowga wuxuu sidoo kale ku lug leeyahay horumarinta dhibaatooyinka, sida dhaawaca xididdada dhiigga, dareemayaasha, iyo xubnaha, taas oo keeni karta dhibaatooyin caafimaad oo halis ah sida cudurka wadnaha, istaroogga, cudurka kelyaha, iyo luminta aragga.
Fahamka cudurka sonkorowga wuxuu muhiim u yahay horumarinta daaweynta wax ku oolka ah iyo istiraatiijiyadaha ka hortagga cudurkan joogtada ah.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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