Alzheimers keselligi öňe barýan neýrodegenerativ kesele esasen beýni täsir edip, ýatlama gowşamasyna, bilişsel gowşama we hereket üýtgänliklerine sebäp bolýar.
Altsgeýmer keseliniň anyk sebäbi doly düşünilmeýär, ýöne ol genetik, daşky we ýaşaýş usuly faktorlarynyň birleşiginden döreýändigi ynanylýar.
Altsgeymer keseliniň döremegine goşant goşýan käbir faktorlara şular degişli:
1. Genetika: Altsgeýmer keseliniň döremegine sebäp bolýan käbir genler, esasanam, E apolipoprotein (APOE) geni anyklandy.
2. Garrylyk: Altsgeýmer keseliniň döremeginiň mümkinçiligi garrylyk bilen artýar.
Maşgala taryhy: Maşgala taryhynyň Altsgeýmer keselinden ejir çekýänleri köp bolýar.
Başyň ýaralanmagy: Başyň ýaralanmagy, esasanam, aljymer keseliniň döremegine sebäp bolup biler.
5. Ýüregiň we gan-damarlaryň agyrymyna sebäp bolýan zatlar: Ganyň basymynyň, galsteriň we süýji keseliniň artmagy Altsgeýmer keseliniň döremegine sebäp bolýar.
6: Ýaşaýyş şertleri: Oturup işlemek, nädogry iýmitlenmek we pikirini hereketlendirmeklik Altsgeýmer keseline eltip biler.
7. Ýagyşlanma: Beýniň yzygiderli ýagyşlanmagy Altsgeýmer keseliniň döremegine sebäp bolup biler.
8. Oksidatsion stres: Erkin radikallaryň emele gelmegi we bedeniň olary detoksik etmek ukybynyň deňsizligi Altsgeymer keseliniň döremegine sebäp bolup biler.
9. Amiloid plaklar we neýrofibrillary topaklar: Beýniň içinde amiloid plaklar we neýrofibrillary topaklaryň birikdirilmegi Altsgeýmer keseliniň nyşanydyr, ýöne olaryň ýagdaýyň ösüşinde tutýan orny doly düşünilmeýär.
Altsgeýmer keseliniň sebäbiniň çylşyrymlydygyny we bu amilleriň birleşigini öz içine alýandygyny unutmaly däl.
Bu howply ýagdaýyň esasy mehanizmlerini gowy düşünmek we netijeli bejergiler taýýarlamak üçin barlaglar dowam edýär.
Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.
Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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['1998-nji ýylyň Digital Millennium Copyright Act, 17 U.S.C. § 512 (DMCA) haky bolanlar üçin Internetde görünýän materiallary ABŞ haky boýunça hukuklaryny bozýar diýip pikir edýänlere çäre görmäge mümkinçilik berýär. ']
['Eger siz biziň web saýtymyz ýa-da hyzmatlarymyz bilen baglanyşykly edip berilýän maglumat ýa-da materiallaryň siziň avtorlyk hukugyňyzy bozýandygyny dogry ynansaňyz, siz (ýa-da wekiliňiz) maglumat ýa-da materiallary aýyrmak ýa-da olara girmegiň bökülmegi barada bize habarlama ýollap bilersiňiz.']
['Habarlamalar elektron poçta arkaly ýazylgy ýollanmaly (elektron poçta jaýyny görmek üçin "Mugallymlar" bölüminde seret).']
['DMCA nusgasyna görä, hakyňy bozmak barada habar bermegiňde şu maglumatlar gerek: (1) hakyňy bozmakda aýyplanýan hakyňy goraýan işiň suratlandyrmasy; (2) hakyňy bozýan maglumatyň suratlandyrmasy we maglumaty tapmaga ýeterlik maglumat; (3) seniň bilen habarlaşmak üçin maglumat, şol sanda seniň adres, telefon we elektron poçtalaryň; (4) seniň hakyňy bozýan maglumatyň hak eýesi ýa-da onuň wekili tarapyndan ýa-da kanun boýunça rugsat berilmändigine gowy ynamyň bardygy barada şaýatlyk.']
['5) Siziň ýalan sözlemek jezasy astynda gol çekip, habarlamada berilýän maglumatyň dogrydigini we siziň bozulan diýip aýyplanýan avtorlyk hukugyny goramaga ygtyýaryňyzyň bardygyny tassyklaýan şaýatlygyňyz;']
['we (6) hak eýesiniň ýa-da hak eýesi adyndan hereket etmäge ygtyýary bolan adamyň fiziki ýa-da elektron goly. ']
['Eger ýokarda agzalan maglumatlaryň ählisini ýazmasaň, şikayetleriňiň çözülmegi giçleşdiriler.']
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['Haýsy soragyňyz / teklibiňiz bar bolsa bize email ýollaň.']
What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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