Ko'krak saratoni patofiziologiyasi ko'krak saratoni rivojlanishiga va rivojlanishiga olib keladigan asosiy mexanizmlar va jarayonlarni anglatadi.
Kolon saratoni, shuningdek, kolorektal saratoni deb ham ataladi, bu katta ichakning bir qismi bo'lgan kolon yoki rektumda boshlanadigan saraton turi.
Odatda u polip deb nomlangan o'sish sifatida boshlanadi, u vaqt o'tishi bilan saraton kasalligiga aylanishi mumkin.
Ko'krak saratoni patofiziologiyasi bir nechta omillarni o'z ichiga oladi, shu jumladan genetik mutatsiyalar, yallig'lanish va atrof-muhit omillari.
Kolon hujayralarining DNKida genetik mutatsiyalar sodir bo'lishi mumkin, bu esa hujayraning nazoratsiz o'sishiga va bo'linishiga olib keladi.
Ushbu mutatsiyalar meros bo'lib o'tishi yoki sotib olinishi mumkin va ular hujayraning o'sishi, bo'linishi va ta'mirlanishi bilan bog'liq bo'lgan turli genlarga ta'sir qilishi mumkin.
Ko'krakning yallig'lanishi, ya'ni ichakning yallig'lanish kasalligi kabi kasalliklar tufayli paydo bo'lishi mumkin, shuningdek, ko'krak saratoni xavfini oshirishi mumkin.
Surunkali yallig'lanish hujayra o'sishi va bo'linishini rag'batlantiradigan kimyoviy moddalar chiqarilishiga olib kelishi mumkin, bu esa saraton rivojlanishiga olib kelishi mumkin.
Atrof-muhit omillari, masalan, ovqatlanish, turmush tarzi va ba'zi kimyoviy moddalarga ta'sir ko'rsatish ham ko'krak saratoni rivojlanishiga hissa qo'shishi mumkin.
Masalan, qizil va qayta ishlangan go'shtlarni ko'p iste'mol qilish ko'krak saratoni xavfini oshiradi.
Boshqa omillar, masalan, semizlik, chekish va jismoniy faollikning etishmasligi ham bu xavfni oshirishi mumkin.
Ko'krak saratoni rivojlanganidan so'ng, u bir nechta bosqichlardan o'tishi mumkin, dastlabki bosqichda ko'krak saratoni ko'krak saratoni bilan cheklangan bo'lib, keyinchalik tananing boshqa qismlariga tarqalgan bo'ladi.
Saraton hujayralari yaqin atrofdagi to'qimalar va organlarga hujum qilishi mumkin, shuningdek limfa tizimi yoki qon oqimi orqali jigar yoki o'pka kabi uzoq joylarga tarqalishi mumkin.
Ko'krak saratoni uchun davolash, odatda, saratonning bosqichi va joylashuviga qarab, jarrohlik, kimyoterapiya va nurlanish terapiyasini o'z ichiga oladi.
Erta aniqlash va davolash natijalarni yaxshilash uchun muhim ahamiyatga ega, chunki ko'krak saratoni dastlabki bosqichida aniqlanganda ko'pincha davolanadi.
Kolonoskopiya kabi muntazam tekshiruvlar ko'krak saratoni eng dastlabki bosqichida, ya'ni davolanishi mumkin bo'lgan vaqtda aniqlashga yordam beradi.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
Mas'uliyatdan voz kechish: tibbiy
Ushbu veb-sayt faqat ta'lim va axborot maqsadlari uchun mo'ljallangan bo'lib, tibbiy maslahat yoki professional xizmatlar ko'rsatmaydi.
Ma'lumotlardan sog'liqni saqlash muammolari yoki kasalliklarni tashxislash yoki davolash uchun foydalanmaslik kerak va shaxsiy tibbiy maslahat so'raganlar litsenziyaga ega bo'lgan shifokor bilan maslahatlashishlari kerak.
Iltimos, savollarga javoblarni ishlab chiqaradigan neyron tarmog'i, ayniqsa, raqamli tarkibga kelganda noto'g'ri ekanligiga e'tibor bering. Masalan, ma'lum bir kasallik bilan kasallangan odamlar soni.
Har doim shifokoringiz yoki boshqa malakali sog'liqni saqlash provayderining maslahatini so'rang. Hech qachon professional tibbiy maslahatni e'tiborsiz qoldirmang yoki ushbu veb-saytda o'qiganingiz sababli uni so'rashni kechiktirmang. Agar siz tibbiy favqulodda vaziyatga duchor bo'lishingiz mumkin deb o'ylasangiz, darhol 911 ga qo'ng'iroq qiling yoki eng yaqin favqulodda vaziyatlar bo'limiga boring. Ushbu veb-sayt yoki uning ishlatilishi bilan hech qanday shifokor- bemor munosabatlari yaratilmaydi. BioMedLib ham, uning xodimlari ham, ushbu veb-saytga hech qanday hissa qo'shuvchi, bu erda taqdim etilgan ma'lumot yoki uning ishlatilishi bilan bog'liq hech qanday bayonot bermaydi.
Mas'uliyatdan voz kechish: mualliflik huquqi
1998-yilgi raqamli ming yillik mualliflik huquqi to'g'risidagi qonun, 17 U.S.C. 512-moddasi (DMCA) Internetda paydo bo'lgan materiallar AQSh mualliflik huquqi to'g'risidagi qonun bo'yicha o'z huquqlarini buzadi deb hisoblaydigan mualliflik huquqi egalari uchun choralar ko'rsatadi.
Agar siz bizning veb-saytimiz yoki xizmatlarimiz bilan bog'liq bo'lgan har qanday tarkib yoki material sizning mualliflik huquqingizni buzadi deb yaxshi ishonchga ega bo'lsangiz, siz (yoki sizning vakilingiz) bizga tarkib yoki materialni olib tashlashni yoki unga kirishni to'xtatishni so'rab xabar yuborishingiz mumkin.
Xabarlar yozma ravishda elektron pochta orqali yuborilishi kerak (elektron pochta manzili uchun "Muloqot" bo'limiga qarang).
DMCA sizning da'vo qilingan mualliflik huquqi buzilganligi to'g'risidagi xabarnomangizda quyidagi ma'lumotlarni o'z ichiga olishini talab qiladi: (1) da'vo qilingan mualliflik huquqi buzilgan asarning tavsifi; (2) da'vo qilingan mualliflik huquqi buzilgan tarkibning tavsifi va bizga tarkibni topishga imkon beradigan etarli ma'lumotlar; (3) siz uchun aloqa ma'lumotlari, shu jumladan sizning manzilingiz, telefon raqami va elektron pochta manzili; (4) siz tomonidan da'vo qilingan tarzda tarkib mualliflik huquqi egasi yoki uning vakili yoki har qanday qonun tomonidan ruxsat berilmaganligiga ishonchingiz borligi to'g'risidagi bayonot;
(5) siz tomonidan yolg'on guvohlik berish jazosi ostida imzolangan, bildirishnomadagi ma'lumotlar to'g'ri ekanligi va siz buzilgan deb da'vo qilingan mualliflik huquqlarini amalga oshirish vakolatiga ega ekanligingiz to'g'risidagi bayonot;
va (6) mualliflik huquqi egasining yoki mualliflik huquqi egasi nomidan harakat qilishga vakolatli shaxsning jismoniy yoki elektron imzosi.
Yuqoridagi barcha ma'lumotlarni kiritmaslik sizning shikoyatingizni ko'rib chiqishni kechiktirishi mumkin.
Aloqa qilish
Iltimos, har qanday savol / taklif bilan bizga elektron pochta xabarini yuboring.
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
Disclaimer: medical
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