How is Alzheimer diagnosed?

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Come se fa a diagnosticar l'Alzheimer?

El morbo de Alzheimer el vien diagnosticà co na combinassiòn de metodi, tra cui na completa vałutasiòn mèdega, test cognitivi e neuropsicologici, imaging cerebrałe e el proceso de eliminassiòn de altre posibiłi cause.

1. Esame mèdego: Un dotor el farà un esame fisico e el farà un'anamnesi detajada par escludare altre posibiłi cause de perdita de memoria o declino cognitivo, come problemi de tiroide, carense de vitamine o tumori al zervel.

2. Test cognitivi e neuropsicologici: Sti test i valuta ła memoria, el linguagio, ła sołusion de problemi e altre funsion cognitive pa determinar l'estensión del danno cognitivo e pa diferensiar tra ła normałe perdita de memoria ligada a l'età e ła demensa.

3. Imaging del zervel: ła imaging a risonansa magnetica (MRI) o ła tomografia computerixada (CT) łe pol jutar a identificar canbiamenti struturałi nel zervel che i pol indicar el morbo de Alzheimer.

Łe scansioni a tomografia a emission de positroni (PET) łe pol anca esar usà pa misurar i livełi de serte proteine asociàe al morbo de Alzheimer.

4. Esami del sangue: Ricerche recenti ga mostrà che certi esami del sangue pol jutar a diagnosticar el morbo de Alzheimer misurando i livełi de specifiche proteine o biomarcatori asocià ała malatia.

5. Processo de eliminasion: Sicome no ghe xe un unico test definitivo pała małatia de Alzheimer, ła diagnosi speso ła implica escludare altre posibiłi cause de sintomi simiłi ała demensa.

Xe inportante ricordar che na diagnosi definitiva deła małatia de Alzheimer ła pol esar fata soło dopo ła morte co un exame del tesùo cerebrałe.

Comunque, i metodi de diagnostica atuali i pol dar un alto liveło de sicuresa pa na diagnosi clinica mentre ła persona ła xe ancora viva.

Ła diagnosi precoce xe importante pa scominsiar el tratamento e pa pianificar el futuro.

['Riferimenti']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

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[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

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Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

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How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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