What is pathophysiology of Lung cancer?

['Déglul xët wii']

Lan mooy patofisiyoloji bu jàngoroy pooj bi?

Jàngoroy feebar yiy tax ba nit am jàngoroy pënd dafay tekki ay coppite ci doxalin ak doxalin yuy tax ba nit am jàngoroy pënd.

Kanser bu pënd bi dafa jafe lool, di jàngoro juy juddoo ci yokkute ak séddale gu amul yoon ci ay selil bu baaxul ci pënd bi.

Cellal yii mën nañu jur ay sëq te law ci yeneen wàll yi yaram wi, indi ay firnde ak ay jafe-jafe yu bare.

Jàngoroy feebar yiy tax ba nit am jàngoroy pënd dafay ànd ak ay sabab yu bari, ñu ci mel ni ay coppite ci gene, ay sabab yu aju ci li muy dund ak li muy dundal.

Yëngu-yënguy gene mën na am ci ADN bu selilukaayu pajum deret ji, di indi yokkute ak séddale selilukaay bu amul benn yoon.

Yëngu-yëngu yooyu mën nañu leen a donn walla ñu jële leen ci nit, te mën nañu juddoo ci ay yëngu-yëngu yuy jur jàngoroy kansaar, niki saxarum saxar, radon, asbestos, ak feebar yiy wàlle ci jaww ji.

Kanser bu tubbëf mën na ko séddale ci ñaari xeeti kansar: kansër bu tubbëf bu ay selil yu ndaw (SCLC) ak kansër bu tubbëf bu ay selil yu ndaw (NSCLC). NSCLC dees na ko séddale ci ñetti xeeti tubbëf: adenocarcinoma, squamous cell carcinoma, ak large cell carcinoma.

Jëfekaayu jàngoroy xëtu bakkan yii mën na wuute, ndax dañuy am ay wuute ci gene yi ñu am te wuute ci ni ñu di ci nangu.

Jàngoroy feebar yiy jur jàngoroy pënd dafay boole itam jokkoo gi am diggante selil yi ak yaram wi ko wër, boole ci sistem bu aar yaram.

Selil yi am jàngoroy kansaar mën nañu rëcc ci sistem bu aar yaram bi, di leen may ñu màgg te law ci lu kenn mënul a tere.

Te itam, microenvironnement bu tumoor bi mën na yokk màggug tumoor bi ak metastase bi ci joxe ab mbay buy dëfal ay selil cancer.

Jàngoroy feebar yiy tax ba nit am jàngoroy bakkan mooy lu jafe te di lu am solo, te ay gëstukat di ci wéy di liggéey ngir gën a xam jëfekaay yi koy waral ngir mën a sos ay faj yu gën a baax te gën a baaxal ñi ci wopp.

['Royuwaay:REF']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.

Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.

Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.

Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .

Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .

Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.

['Waxtaan: wér-gu-yaram']

['Web bii dañu koy defar ngir jàngal ak a xamle rekk te du ngir jox ay digal ci wàllu wér-gu-yaram walla ay liggéey yu ñu mën a def.']

['Xam-xam bi ñu leen di jox waruñu koo jëfandikoo ngir seet walla faj wér-gi-yaram walla jàngoro, te ñi bëgg a laaj ay leeral ci wàllu wér-gi-yaram war nañu seeti doktoor bu ñu nangu.']

['Seetal ne jàmbaar gii di sàkk tontu yi ci laaj yi, dafa ñàkk solo lool ci lu jëm ci limu limu nit ñi, niki limub ñi ñu jàngal ab jàngoro.']

['Danga war a wutal sa doktoor walla beneen fajkat bu am xam-xam ci lu jëm ci wér-gu-yaram. Bul sàggane walla nga gaaw a wutal sa doktoor ndax dara lu nga jàng ci dal bii. Soo xalaatee ne am nga lu la soxla ci wér-gu-yaram, wool 911 walla nga dem ci fajukaay bu la gën a jege ci saa si. Dal bii walla jëfandikoo ko taxul nga nekk ak ab doktoor walla ab jarag. BioMedLib walla ay liggéeykatam, walla kenn ci ñi koy jëfandikoo, duñu wax dara, muy lu leer mbaa lu leeradi, ci lu jëm ci xibaar yi ñu leen di jox fii walla ci ni ñu koy jëfandikoo.']

['Séddo: sañ-sañu jëfandikoo']

['Sàrtu sàmm-sañu-xët yi ñu bind ci Internet ci atum 1998 (Digital Millennium Copyright Act of 1998), 17 U.S.C. § 512 (ci angale mooy DMCA) dafay may boroom-sañu-xët yi ñu jàpp ne ay mbind yu feeñ ci Internet dañuy yàq seen sañ-sañ ci yoon wi ñu bind ci Amerig. ']

['Sudee gëm nga ci lu wér ne lenn ci li nekk ci sunu dal bi walla ci sunuy liggéey dafa moy say sañ-sañ, yaw (mbaa sa jawriñ) mën nga nu yónnee ab bataaxal di laaj ñu dindi li nekk ci dal bi walla ci liggéey bi, walla ñu téye sa jàll ci moom. ']

['Bind nañu ay yëgle ci mbind, ci ab bataaxal (Xoolal "Contact" ngir xam màkkaanu bataaxal bi).']

['DMCA dafa digle ne sa bataaxal bu jëm ci jàddug sañ-sañ bu ñu sos war na ëmb li ci topp: (1) xët wu jëm ci liggéey bi ñu sos ne jàdd nañ ko; (2) xët wu jëm ci li ñu sos ne jàdd nañ ko ak ay xibaar yu doy ngir may nu nu nu man a gis li mu ëmb; (3) ay xibaar yu jëm ci yaw, boole ci sa màkkaanu dal, sa limu telefóni ak sa màkkaanu imeel; (4) ab kàddu bu jóge ci yaw bu lay xamal ne am nga yaakaar bu wér ne li nga sos ci anam wi ñu la ko sosu, moom boroom sañ-sañ bi, walla ki ko dénk, walla benn yoon, nanguwu ko; ']

['(5) ab bataaxal bu ñu la jox, nga dëggal ci sa loxo ne li nga bind dëgg la te am nga sañ-sañu sàmm sañ-sañu jëfandikoo sañ-sañu bind bi ñu la sosal ne yàqu na;']

['ak (6) benn màndarga buy firndeel walla buy wone ay màndarga yuy wone ne moom la sañ-sañu jëfandikoo walla mu ngi koy jëfandikoo ci turu moom. ']

['Suñ la ci dugalul lépp lu ñu wax ci kaw, mën na tax ba say tawat di gaaw a jàppale.']

['Waxtaan']

['Yónneel nu ab imeel bu la laaj walla nga am ay xalaat.']

What is pathophysiology of lung cancer?

The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.

Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.

These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.

The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.

Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.

Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.

The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.

Cancer cells can evade the immune system, allowing them to grow and spread unchecked.

Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.

The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.

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