What causes Alzheimer?

['Ivwilila ku chihanda chino']

Yika yakuneha yikola ya Alzheimer?

Musongo wa Alzheimer uli yikola yize yakupinjisa wongo, yakupinjisa wongo, ni kupinjisa manyonga ni yitanga.

Mumu liaka atu akupwa ni yikola yacho, kuchanyingikine kanawa, alioze kakufuliela ngwo yakuneha kuli atu a ku musunya, ku yitanga ni ku yitanga ya atu.

Yuma yize muyihasa kulingisa mutu apwe ni yikola yacho yili:

1. Shimbi ja mu jimo: Shimbi jimwe ja mu jimo jakukwasa atu kupwa ni yikola ya Alzheimer, chilemu chinji shimbi ya apolipoprotein E (APOE).

2. Mushinakaji: Uhashi wa kupwa ni yikola yacho wakuya ni kukola chinji, mumu atu anji kakuyiza nayo muze hanahichi miaka 65.

3. Usoko: Nyi umwe mu usoko we kali ni yikola yacho, chino muchihasa kutohwesa yikola yacho.

4. Kuputa mu mutwe: Nyi mutu hapwa ni kuputa mu mutwe, chipema nyi kakupuka, chino muchihasa kumulingisa apwe ni yikola ya Alzheimer.

5. Yuma yize yakuneha yikola ya mbunge: Yikola ngwe, manyinga apema, cholesterol, ni yikola ya shuga, muyihasa kukolesa yikola ya Alzheimer.

6. Yuma yize yakuneha yikola yacho: Kutwama wika, ni kuhona kulia kanawa, ni kuhona kulinga yize mufupa mufupa mufupa muzanga kulinga, muchihasa kutohwesa yikola yacho.

7. Kufwika: Kufwika cha wongo che chakuneha yikola ya Alzheimer.

8. Musongo wa Alzheimers: Musongo wacho wakuneha yikola yize yakuneha yikola ya kapinda mu mujimba.

9. Malita ni yihanda ya mu wongo: Kuvula cha malita ni yihanda ya mu wongo chili chijimbikilo cha yikola ya Alzheimer, alioze mulimo wo kuchinyingiwe kanawa.

Chili chilemu kunyingika ngwo, chishina chakuneha yikola ya Alzheimer chili chikalu chinji, nawa chakuneha yuma yinji.

Sango jinji kanajifwambwishila hanga atu anyingike kanawa yize yakuneha yikola yacho ni kuchiza yitumbo yize muyihasa kuyuka yikola yacho.

['Kuhanjika']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

['Ulemu: ukwaso wa yikola']

['Site yino kayitela hanga atu anyingike hakutwala ku yikola ni yikuma yikwo, kuyishi ni yiyulo ya mandotolo.']

['Sango jacho katambile kujizachisa hanga awane hanji awahise yikola, nawa waze anafupu yiyulo ya mandotolo katamba kuya kuli ndotolo.']

['Tala ha makina yize yakukwasa hanga uwane kumbululo lia yihula, hi yikalu ko muze anavuluka unji wa atu waze ali ni yikola.']

['Teta mashimbu eswe kuwana yiyulo ya ndotolo we hanji umwe mukwa-kuhana yiyulo ya uhayele ha chikuma cha yikola. Kanda ulionga yiyulo ya ndotolo hanji kutohwesa kuyitanga ha mukunda wa yimwe yuma yize watanga ha site yino. Nyi wanyonga ngwo uli ni mulonga wa uhayele, shinga 911 hanji yako ha chipatulo cha usopeso chize chili hakamwihi. Kukushi usepa wa ndotolo ni ndotolo uze wakunjila ha site yino hanji ha kuzachisa site yino. Chipwe BioMedLib hanji akwa-kukalakala nayo, hanji yoze wakukwasa ha site yino, keshi kulinga nichimwe, chipwe kusolola, hakutwala ku sango jize jili ha site yino hanji ha kuzachisa site yino.']

['Uhashi wa akwa-kusoneka']

['Shimbi ya Digital Millennium Copyright Act ya 1998, 17 U.S.C. § 512 (DMCA) yinambe ngwo, waze ali ni shimbi ja akwa-kusoneka waze anafuliela ngwo yuma yize yili ha Internet yinapinjisa shimbi ja akwa-kusoneka ja mu Estados Unidos. ']

['Nyi unafuliela ni mbunge yeswe ngwo yikuma yeswe yize akuzachisa ha site yino yinapinjisa shimbi ja akwa-kusoneka, yena (mba yoze wakuzachisa) muhasa kututumina mukanda hanga ututuhwise yikuma yacho hanji kuhona kuyimona.']

['Sango jacho katamba kujituma ha mukanda ha email (tala ha chihanda cha "Contact" ha email).']

['Shimbi ya DMCA yinambe ngwo, sango je ha yize akuhanjika ngwo yapinjisa shimbi ja akwa-kusoneka yili ni sango jacho: (1) kulumbununa mulimo uze uli ni shimbi ja akwa-kusoneka uze anazangamisa; (2) kulumbununa yikuma yize anazangamisa ni sango jize jinahase kutukwasa hanga tuwane yikuma yacho; (3) kulweza yoze mutuhasa kumuheta, ngwe adresi, numero ya telefone ni email; (4) maliji waze yena musolola ngwo, yuma yize anazangamisa kuyishi ni utayizo wa mwene wa shimbi ja akwa-kusoneka, hanji yoze akuzachisa, hanji ni shimbi jize anazangamisa; ']

['(5) Sango jize yena musoneka, ni shimbi jize makahana, ngwo sango jize jili ha mukanda jili ja umwenemwene nawa uli ni ulite wakukwasa hanga akwa-kusoneka afunge shimbi jize anakwambulula ngwo jinalitepulula;']

['nawa (6) chijimbikilo cha mwata wa shindakenyo ya ulite wa yuma hanji cha muthu yoze uli ni ulite wa kulinga yuma ha jina lia mwata wa shindakenyo ya yuma.']

['Nyi kuhona kusa sango jacho mu mukanda, kuchihasa kutohwesa chikuma chikuma.']

['Kulitakana']

['Tutuminenu mukanda ni yihula ni yiyulo yenu.']

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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