Kë ye cɔl 'pathophysiology of colon cancer' ee yen nyuɔɔth ke ye tuanytuɛɛny tɔ̈ në raan guöp yic kek ye lac bɛ̈n në raan guöp yic.
Colon cancer, aye cɔl colorectal cancer, ee tuany ë cancer ye rot jɔɔk në colon ka rectum, man ye biäk de tuɛnytuɛny dït.
Ee rot lac jɔɔk ke ye cil cɔl polyp, man lëu bï rot ya juak ku bï ya tuaany.
Kë ye cɔl 'pathophysiology of colon cancer' ee yen naŋ kä juëc ye kek cɔk loi röt, agut cï kä ye röt waar në genetic yic, tuanytuɛɛny, ku jɔl ya kä ye röt looi në piny yic.
Gɛ̈ɛ̈r de kä ke genetic alëu bï rot ya looi në DNA de colon cells yic, man ye cell ya cɔk cil ku bï ya tek.
Kä cï röt waar käkë alëu bï kek ya yök në raan yic ka bïk ya tɔ̈ në yen, ku ka lëu bïk genes juëc ya cɔk loi röt në cil de cell yic, ku bï kek ya tek yiic ku bï kek ya cɔ̈kpiny.
Tuɛnytuɛny tɔ̈ në yïcök dït yic, man lëu bï ya kë de tuanytuɛny ke yïcök dït, alëu bï tuanytuɛny ke colon cancer juak.
Tuɛnytuɛnytuɛɛny ye lac bɛ̈n alëu bïk chemicals ya looi ku bïk cell ya juak ku tekkë röt, ku ka lëu bïk tuany de cancer ya looi.
Kä ye röt looi në ɣän kɔ̈k yiic, cïmën de mïïth ye kek cam, pïïrden, ku jɔl ya kä ye kek dek në chemicals kɔ̈k yiic, alëu bïk tuany de colon cancer ya juak.
Ciin de mïïth tɔ̈ në ciin de cuäŋ yic ku mïïth cï kek ya looi, në nyooth, acï kek ya rek kenë tuany de colon cancer.
Kä kɔ̈k, cït mɛn dït de guɔ̈p, tajiir, ku cïn kë ye looi, alëu bïk ciin de tuaany juak.
Na cï tuany de colon cancer rot lac looi, ke ka lëu bï ya naŋ ciin juëc ye kek lac juak yiic, jɔɔk në tuany tueeŋ de colon cancer yic agut cï ciin dït cï tuany de cancer ya ɣet në biäk kɔ̈k ke guɔ̈p yic.
Käm 'cancer cells' alëu bïk ya lɔ në guöp tɔ̈ në kek kɔ̈ɔ̈th ku bïk ya tekthok, ku ka lëu bïk ya tekthok në lymphatic system ka riɛm yic ku bïk ya lɔ në guöp kɔ̈k peei yiic, cïmën de liver ka lungs.
Wal tuany de colon cancer aye yen mat thïn ëbën agut cï tuany de chemotherapy, ku jɔl ya radiation therapy, ku ka ye rot gɛɛi në tuany de cancer.
Yök de tuany ku kony de tuany në ye thaa kän ee kë thiekic ago kä ye yök ke tuany ya cɔk piath, në kë yenë tuany de colon cancer lac kony në ye thaa ɣɔn cenë yen lac yök.
Thëm de rɔt, cït mɛn colonoscopy, alëu bï tuany de colon cancer ya yök në thɛɛr tueeŋ yiic, të lëu benë yen ya kony.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
['Wɛ̈t cï lueel: wal']
['Wɛbthait kën ee piööc ku wël tɔ̈u thïn ku acie kë ye looi bï kɔc ke akïm ya lɛ̈k wala bï kɔc ke luɔi ya kony.']
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['Tiɛ̈ŋë kä ye kuɔɔny de neural net looi, man ye kä ye bɛ̈n në kä cï kek ya thiëëc yiic, aye kek cɔk tɔ̈ ëke cïï kek ye deet yiic në thɛɛr juëc yiic. Cïmën de, ciin de kɔc cï kek yök ëke tuany.']
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["Wël aa bë ke tuɔɔc në athöör yic në email (tïŋ 'Rin de athöör' në biäk de email)."]
['DMCA ee wïc lɔnadɛ̈ ke kë ca lueel de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i anɔŋic wël cï keek gɔ̈ɔ̈r: (1) luɛɛl de kä cï keek luɔ̈ɔ̈i cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i cï keek lueel; (2) luɛɛl de kä cï keek gɔ̈ɔ̈r cï keek lueel ku wël cï keek lueel bï keek cɔk lëu bïkë kä cï keek gɔ̈ɔ̈r yök; (3) wël bï yïn ke kɔn ya kɔɔr, nɔŋiic adrɛ̈ɛ̈rdu, namba de telepun ku adrɛ̈ɛ̈r de imeel; (4) wɛ̈t cï lueel në yï nhom lɔnadɛ̈ ke yïn ye gam ke kë cï gɔ̈ɔ̈r cï looi në kueer cï yïn ye gaam acie gam në raan de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i, ka raan de lööŋ, ka në luɔɔi de löŋ; ']
['(5) athöör cï yïn gätpiny në awuɔ̈c de wɛ̈t lueth, lɔnadɛ̈ ke wël tɔ̈ në athöör yic aye yith ku lɔnadɛ̈ ke yïn anɔŋ riɛl ba kä cï gɔ̈t ke lööŋ ke raan nɔŋ nhïïm ya looi në kë cï wuɔ̈ɔ̈c; ']
['Ku (6) ke ye kä cï gɔ̈t ke guɔ̈p ka kä cï gɔ̈t ke mɛ̈ɛ̈t de raan de kä cï luɔ̈ɔ̈i ka raan cï gäm riɛl bï luui në nyin de raan de kä cï luɔ̈ɔ̈i. ']
['Na këc wël cï gɔ̈ɔ̈r nhial tɔ̈u thïn kedhiɛ gɔ̈t, ke ka lëu bï këdun cï yïn gaam ya gääu.']
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
Disclaimer: medical
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