What is pathophysiology of Diabetes?

['Piŋë në ye athöörë yic']

Ye tuanyëcuäny de cuäŋ ŋö?

Puɔ̈ɔ̈c de tuany de cuäŋ aye jam në puɔ̈ɔ̈c de tɛ̈n yenë tuany de cuäŋ rot luɔɔi thïn ku ka ye tuany de cuäŋ bɛ̈n cɔk loi rot.

Tuanyëcuäny (diabetes mellitus) ee tuanytuɛnytuɛɛny ke cuäŋ ye röt lac looi në riɛmic (glucose) ye rot lac looi në kë de tuanytuɛɛny ke insulin, ka kë ye kek looi në insulin, ka kedhiɛ.

Kä ye tuaany de cuäŋ cɔl 'pathophysiology of diabetes' nyuɔɔth ee käjuëc ye röt looi në kaam de genetic, environmental, ku jɔl ya tɛ̈n yenë raan pïïr thïn, man ye tuany cɔl 'diabetes' bɛ̈i.

Në tuaany de type 1 diabetes, ke pathophysiology ee yen mat thïn ëbën agut cï autoimmune destruction de insulin-producing beta cells tɔ̈ në pancreas yic, man ye insulin ya looi ke cie lac piath.

Kän ee yen cɔk lëu bï glucose ya mac apath në riɛm yic, ku ka ye yen cɔk cɔl hyperglycemia (blood sugar) ya juak.

Në tuaany de type 2 diabetes, ke pathophysiology ee yic rilic apɛi ku ee yen mat thïn ëbën agut cï insulin resistance ku jɔl ya insulin secretion.

Insulin resistance ee rot looi të cïï cells ke guɔ̈p bɛɛr luui apath në insulin, man ye glucose cɔk lëu bï ya looi ke ye miök.

Kän ee pancreas cɔk looi insulin bï yen ya them bï riɛl de insulin ya tiaam, ku na lä thɛɛr, ke pancreas acïï lëu bï ya rëër ke wïc insulin, ku kän ee insulin ya cɔk loi rot.

Kë ye cɔl Gestational diabetes, man ye rot looi në thaa de meth, ee rot looi në kë de hormones ye kek röt waar ku ye kek cɔk luui apath në insulin.

Mïth aye käm cɔl 'hormones' looi man lëu bïk insulin ya gël ago ya luui apath, ku bï ciin de glucose ya juak në riɛm yic.

Kë ye cɔl 'pathophysiology of diabetes' ee yen mat thïn ëbën agut cï kä ye yen cɔk ril yic, cïmën de riääk de riɛm, kä ye raan riɔ̈ɔ̈k, ku jɔl ya guöp, man lëu bï raan ya gäm tuaany de cuäŋ, tuaany de nhom, tuaany de cuäŋ, ku jɔl ya kë ye raan daai.

Puɔ̈ɔ̈c de pathophysiology de tuaany de cuäŋ ee kë thiekic apɛi ago wɛ̈l ye tuaany gël ku bï tuaany de cuäŋ ya lac looi.

['Kä cï gɔ̈ɔ̈r']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

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['Na ye gam në yith ke këriɛ̈ɛ̈c ka kä cï gɔ̈ɔ̈r tɔ̈ në wɛbthaitda ka kuɔɔnyda yic acï löŋ de gël de kä cï gɔ̈ɔ̈r dhoŋ kɔ̈u, ke yïn (ka raan ye yïn luɔ̈ɔ̈i) alëu ba ɣok tuɔ̈c wɛ̈t bï këriɛ̈ɛ̈c ka kä cï gɔ̈ɔ̈r nyaai, ka bï yïn pëën ba lɔ thïn. ']

["Wël aa bë ke tuɔɔc në athöör yic në email (tïŋ 'Rin de athöör' në biäk de email)."]

['DMCA ee wïc lɔnadɛ̈ ke kë ca lueel de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i anɔŋic wël cï keek gɔ̈ɔ̈r: (1) luɛɛl de kä cï keek luɔ̈ɔ̈i cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i cï keek lueel; (2) luɛɛl de kä cï keek gɔ̈ɔ̈r cï keek lueel ku wël cï keek lueel bï keek cɔk lëu bïkë kä cï keek gɔ̈ɔ̈r yök; (3) wël bï yïn ke kɔn ya kɔɔr, nɔŋiic adrɛ̈ɛ̈rdu, namba de telepun ku adrɛ̈ɛ̈r de imeel; (4) wɛ̈t cï lueel në yï nhom lɔnadɛ̈ ke yïn ye gam ke kë cï gɔ̈ɔ̈r cï looi në kueer cï yïn ye gaam acie gam në raan de kä cï keek gɔ̈ɔ̈r cï keek luɔ̈ɔ̈i, ka raan de lööŋ, ka në luɔɔi de löŋ; ']

['(5) athöör cï yïn gätpiny në awuɔ̈c de wɛ̈t lueth, lɔnadɛ̈ ke wël tɔ̈ në athöör yic aye yith ku lɔnadɛ̈ ke yïn anɔŋ riɛl ba kä cï gɔ̈t ke lööŋ ke raan nɔŋ nhïïm ya looi në kë cï wuɔ̈ɔ̈c; ']

['Ku (6) ke ye kä cï gɔ̈t ke guɔ̈p ka kä cï gɔ̈t ke mɛ̈ɛ̈t de raan de kä cï luɔ̈ɔ̈i ka raan cï gäm riɛl bï luui në nyin de raan de kä cï luɔ̈ɔ̈i. ']

['Na këc wël cï gɔ̈ɔ̈r nhial tɔ̈u thïn kedhiɛ gɔ̈t, ke ka lëu bï këdun cï yïn gaam ya gääu.']

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What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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