Na pathophysiology ni kenisa ni sucu e vakaibalebaletaki ena veisau ni ivakarau ni yago kei na ka e dau yaco ena gauna e tubu tiko kina na kenisa ni sucu.
E okati kina na kena vakadikevi na veika bula kei na veika somidi e vakavuna na tubu kei na tete ni sela ni kenisa ena yate.
E okati kina na genetic, epigenetic, kei na environmental factors e vakavuna na kenisa ni sucu.
E so na veisau lelevu e dau yaco ena kenisa ni sucu e okati kina:
1. Veisau ni gene: Na veisau ni gene me vaka na BRCA1 kei na BRCA2 e rawa ni vakavuna na kenisa ni sucu.
Na veisau oqo e rawa ni dewavi se rawati ena gauna e bula tiko kina e dua.
2. Na kena sega ni veiraurau na hormone: Na hormone, vakabibi na estrogen, e rawa ni vakavuna na kenisa ni sucu.
Ke sega ni veiraurau na iwiliwili ni hormone se sivia na estrogen, e rawa ni tubu na kena rawa ni tauvi iko na kenisa ni sucu.
3. Vuvuce: Na vuvuce ni tikiniyago ni sucu e rawa ni vakavuna na kenisa ni sucu ni tubu qai bula tiko ga kina na sela ni kenisa.
4. Na vanua e tubu tiko kina na kenisa: Na vanua e tubu tiko kina na kenisa, wili kina na sela ni yago, na sela ni sotia ni yago, kei na sala ni dra, e rawa ni vakavuna na tubu kei na tete ni kenisa ni sucu.
5. Metastasis: Na kenisa ni sucu e rawa ni tete ina so tale na tikiniyago ena sala ni dra, qai vakavuna me tubu tale kina na kenisa ena so tale na tikiniyago.
E bibi me kilai na ka e dau vakavuna na kenisa ni sucu me rawa ni tarovi kina, kilai totolo, qai qaravi vinaka.
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Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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