What is pathophysiology of Diabetes?

['Ðǒtó wexwɛ elɔ']

Etɛ ka nyí azɔmɛ alɔkpa alɔkpa ɖò azɔnkwín yɛzɔnnɔ ɔ mɛ?

Azɔnkwín sín nǔ nɔ nyí pathophysiology é nɔ dó gesí nǔ e nɔ nyí nǔ nɔ jɛ ɖò agbaza mɛ lɛ é bo nɔ zɔ́n bɔ è nɔ jɛ azɔnkwín zínzán jí é.

Azɔnkwín zínzán tɔn ɔ́ nyí azɔn alɔkpa ɖé bɔ sukpɔ́ e ɖò hun mɛ é nɔ́ jɛji bɔ é nɔ́ zɔ́n bɔ è nɔ ɖó insulin kpɛɖé kpɛɖé.

Nǔ e nɔ zɔ́n bɔ azɔnkwín ɔ nɔ gblé lɛ é wɛ nyí nǔ e nɔ tɔ́n sín gbɛtɔ́ sín jɔwamɔ mɛ lɛ é, nǔ e nɔ dó mɛ lɛ é kpo gbɛzinzan mɛtɔn kpo.

Ðò hwézɔnnɔzɔnnɔ alɔkpa 1 ɔ mɛ ɔ, nǔ nɔ zɔ́n bɔ è nɔ hu azinzɔ́n nɔ bló insulin lɛ é é wɛ nyí nǔ nɔ nyí gbɔn ɖò agbaza ɔ mɛ é.

Enɛ nɔ zɔ́n bɔ è nɔ kpéwú bo nɔ bló bɔ sukpɔ́ e ɖò hun mɛ é nɔ nɔ jí ǎ, bɔ enɛ nɔ zɔ́n bɔ sukpɔ́ e ɖò hun mɛ é nɔ yì jǐ.

Ðò hwézɔnnɔ alɔkpa 2 ɔ mɛ ɔ, nǔ e nɔ zɔ́n bɔ è nɔ jɛ azɔn lɛ é nɔ vɛwǔ tawun, bɔ é nɔ byɔ ɖɔ è na ɖó insulin sín hudo ǎ, bɔ è na lɛ́ ɖó insulin sín hudo ǎ.

Insulin nɔ kpé lanmɛ nú agbaza ɔ hwenu e agbaza ɔ sín nǔ lɛ nɔ yí gbè nú insulin ganji ǎ é, bɔ enɛ nɔ zɔ́n bɔ é nɔ kpéwú bo nɔ zán glucose dó na hlɔnhlɔn agbaza ɔ ǎ.

Enɛ nɔ zɔ́n bɔ è nɔ ɖè insulin gègě sín ètín ɔ mɛ dó ɖí xwi xá nǔ e è nɔ ɖí xwi xá é, amɔ̌, ɖò hwenu ɖò yiyi wɛ é ɔ, è sixu wá mɔ ɖɔ è kún sixu kpéwú bo ɖè insulin ɔ bǐ ó, bɔ enɛ nɔ zɔ́n bɔ è nɔ ɖè insulin kpɛɖé.

Azɔnkwín nɔ nyí sukpɔ́ ɖò vǐkpo ɔ mɛ é, ee nɔ wá ɖò xò hwenu é ɔ, huzuhuzu e nɔ jɛ ɖò lanmɛ nú mɛ lɛ é wɛ nɔ zɔ́n bɔ è nɔ ɖó sìn e nɔ zɔ́n bɔ è nɔ ɖó insulin é ǎ.

Akɔví ɔ nɔ ɖè nǔ ɖěɖee nɔ sú ali dó nǔwiwa insulin tɔn bɔ é nɔ zɔ́n bɔ sukpɔ́ e ɖò hun mɛ é nɔ yì jǐ é.

Akpáxwé lanmɛ nɔ wà nǔ dó lanmɛ wu ɖò azɔnkwín ɔ hwenu lɛ é nɔ lɛ́ byɔ ɖɔ è ni ɖó tagba ɖevo lɛ, ɖi hunjɔjɔ, nǔ nɔ wà nǔ dó lanmɛ nú mɛ lɛ é kpo agbaza sín wǔjɔnú lɛ kpo gblé, bɔ enɛ sixu zɔ́n bɔ azɔn syɛnsyɛn lɛ nɔ wá ɖi hǔnzɔn, kanjɔzɔn, xomɛzɔn kpo nukúntíntɔ́nnɔ kpo.

Tuùntuùn nǔ e nɔ zɔ́n bɔ azɔn nɔ gblé mɛ lɛ é ɖò taji tawun bonu è na dó sixu kpé nukún dó azɔn syɛnsyɛn enɛ wu bo lɛ́ kpé nukún dó ye wu.

['Nǔ ɖevo lɛ']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

['Nǔgbɛnúmɛ: dotóoxwé sín']

['Nǔkplɔnkplɔn kpo nǔsisɔ kpo sín azɔ̌ kɛɖɛ wɛ è nɔ wà dó tɛn ɛntɛnɛti tɔn elɔ jí, bo nɔ na wěɖexámɛ dotóoxwé tɔn alǒ azɔ̌ ɖevo lɛ mɛ ǎ.']

['È ɖó na zán nǔ e è kplɔ́n mɛ lɛ é dó ba azɔn ɖé alǒ azɔn ɖé sín wuntun alǒ dó gbɔ na ǎ, bɔ mɛ ɖěɖee jló na ba wěɖexámɛ dotóo tɔn lɛ é ɖó na yì mɔ dotóo e ɖó acɛ bo nɔ wà azɔ̌ ɖò dotóoxwé é ɖé.']

['Mi ni flín ɖɔ nǔ e è nɔ ylɔ ɖɔ "neural net" bo nɔ na xósin nú nǔkanbyɔ lɛ é ɔ, nǔ e nɔ nyí nǔjɛdo tawun é wɛ nyí nǔ ɖěɖee è nɔ ylɔ ɖɔ "numeric content" lɛ é. Ði kpɔ́ndéwú ɔ, mɛ nabi è mɔ azɔn ɖé na é.']

['Nɔ ba wěɖexámɛ dotóo towe tɔn alǒ dotóo ɖevo e ɖó nǔwukpikpé é tɔn dó azɔn ɖé wu hwebǐnu. Ma wɔn wěɖexámɛ dotóo tɔn lɛ gbeɖé ó, alǒ ma lin tamɛ kpɔ́n dó nǔ e a xà ɖò tɛn ɛntɛnɛti tɔn elɔ jí lɛ é wu ó. Enyi a lin ɖɔ azɔn baɖabaɖa ɖé ɖò xwi ɖí xá we wɛ hǔn, ylɔ 911 alǒ yì dotóoxwé e sɛkpɔ we hugǎn é tlolo. Tɛn ɛntɛnɛti tɔn elɔ alǒ nǔ e a nɔ zán lɛ é nɔ zɔ́n bɔ kancica dotóo-azinzɔnnɔ ɖé tɔn nɔ tíìn ǎ. BioMedLib, azɔ̌watɔ́ tɔn lɛ, alǒ mɛ ɖevo ɖebǔ e nɔ wlan nǔ dó tɛn ɛntɛnɛti tɔn elɔ jí lɛ é nɔ ɖè kúnnuɖenú ɖebǔ xlɛ́, bo tlɛ nɔ ɖɔ lɔ ǎ, dó nǔ e è ɖɔ ɖò fí lɛ é alǒ nǔ e è nɔ zán lɛ é wu.']

['Nǔɖògbɛ́jlatɔ́ lɛ']

['Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (the DMCA) nɔ na acɛ mɛ e ɖó nǔɖokan yetɔn lɛ é bɔ ye na dó ba nǔɖe bo dó sixu mɔ nǔ e ye ɖó lɛ é ɖò Internet jí.']

["Enyi a ɖi nǔ ɖɔ nǔ ɖĕbǔ ɖò tɛn ɛntɛnɛti tɔn mǐtɔn jí alǒ azɔ̌wiwa mǐtɔn lɛ jí bo hɛn nǔ dó así nú mɛ ɔ, é xò nǔ dó acɛ nǔɖògbɛ́ towe lɛ wu ɔ, hwi (alǒ mɛ e nɔ kpé nukún dó wǔ towe é) sixu sɛ́ wɛn dó mǐ, bo byɔ ɖɔ mǐ ni ɖè nǔ ɖ'emɛ lɛ sín tɛn ɔ jí, alǒ ɖɔ mǐ ni sú ali dó mɛ."]

["È ɖó ná sɛ́ mɛ dó gbɔn email jí (e-mail è nɔ dó ɔ́' kpɔ́n 'Kɔntaktɔ́' ɔ́)."]

['DMCA byɔ ɖɔ ɖɔ nǔ elɔ lɛ ni nɔ akpáxwé nǔ e a ɖɔ é gbà acɛ dó nǔ é tɔn jí é: (1) xó dó azɔ̌ e ɖó acɛ dó nǔ é jí; (2) xó dó nǔ e ɖó acɛ dó nǔ é jí, kpo nǔ ɖevo e na zɔ́n bɔ mǐ na mɔ nǔ ɔ lɛ é kpo; (3) xó dó hwiɖée wu, ɖi adlɛsi towe, alokan towe kpo email towe kpo; (4) xó ɖɔ dó nǔ e wu a ɖi nǔ ɖɔ nǔ e ɖó acɛ dó nǔ e jí a ɖɔ é jí é kún nyí nǔ e ɖó acɛ dó nǔ é jí tɔn ɔ, alǒ mɛ e nɔ kpé nukún dó nǔ é tɔn wu é sín acɛ ó; ']

["(5) Ðɛ́ mɛ̀ è mi sɔ́ alɔ dó ɖ'así ná ɖò hwɛɖɔxɔsá ɔ́' è ɖó ná ɖó hwɛ̀ ɖɔ̀ xó è mi ɖɔ ɖò mɛ̀ è mi dó wèmá ɔ́ mɛ̀ ɔ́' sɔgbe bɔ̀ mi ɖó acɛ̀ bó ná dó ba ɖɔ è ní sú nǔ è è dó wèmá ɔ́ wú lɛ́ɛ sín axɔ́."]

['bɔ (6) alɔ wlanwlan mɛ e ɖó acɛ dó nǔ é tɔn alǒ mɛ e ɖó acɛ bo na wà nǔ dó wutu tɔn é tɔn. ']

['Nú a ma gɔ́ nǔ e ɖò jí lɛ é bǐ ǎ ɔ, é sixu zɔ́n bɔ è na lín có bo na dóhwɛ we.']

['Wǎ kpé mì']

['Mi kɛnklɛn bo sɛ́ nǔkanbyɔ mitɔn lɛ dó mǐ gbɔn e-mail jí.']

What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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