La malatie di Alzheimer e je une malatie neurodegenerative progressive che e interesse soredut il cerviel, causant pierdite di memorie, declin cognitîf e cambiaments comportamentâi.
La cause precise de malatie di Alzheimer no je stade ancjemò ben capide, ma si crôt che e sedi il risultât di une cumbinazion di fatôrs gjenetics, ambientâi e dal mût di vivi.
Fats che a puedin contribuî al svilup de malatie di Alzheimer a son:
1. gjenetiche: cierts gjens a son stâts identificâts che a aumentin il risi di vê la malatie di Alzheimer, in mût particolâr il gjen de apolipoproteine E (APOE).
L'Alzheimer al è il tierç plui grant disvilup di cheste malatie intal mont, e al cjape dentri plui di un miâr di personis.
3. Storie di famee: vê une storie di famee di malatie di Alzheimer al pues aumentâ il risi di svilupâ la cundizion.
4. Feridis al cjâf: une storie di feridis al cjâf, in particolâr chês che a puartin a pierdite di cussience, a puedin aumentâ il risi di malatie di Alzheimer.
5 - Fatôrs di risi cardiovascolârs: cundizions come la pression alte, il colesterôl alt e il diabete a puedin aumentâ il risi di vê la malatie di Alzheimer.
6 Fatôrs di stîl di vite: un stîl di vite sedentari, une alimentazion scjadente e une mancjance di stimui mentâi a puedin aumentâ il risi di malatie di Alzheimer.
7 Infiammazion: la infiammazion croniche tal cerviel e pues contribuî al svilup de malatie di Alzheimer.
8. Stress ossidât: un disecuilibri tra la produzion dai radicâi libars e la capacitât dal cuarp di disintossicâju al pues contribuî al svilup de malatie di Alzheimer.
Plachis amiloidis e gropis neurofibrilaris: la acumulazion di plachis amiloidis e gropis neurofibrilaris tal cerviel e je un aspiet distintîf de malatie di Alzheimer, ma il rûl che a àn tal svilup de cundizion nol è stât capît ben.
Al è impuartant savê che la cause de malatie di Alzheimer e je complesse e e viôt une cumbinazion di chescj fatôrs. ❚
La ricercje e je in cors par capî miôr i mecanisims che a stan sot e svilupâ trataments eficaçs par cheste cundizion devastante.
Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.
Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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['Par plasê note che la rêt neuronâl che a gjenere lis rispuestis aes domandis, e je imprecise soredut cuant a si trate di contignûts numerics.']
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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