La fisiopatologjie dal tumôr de mamm e si riferìs ai cambiaments anormai intai procès e mecanisims fisiologjics normâi che a sucedin tal svilup e la progression dal tumôr de mamm. ❚
Al impliche il studi dai mecanisims biologjics e molecolârs che a condusin ae cressite e ae difusion incontrolade des celulis dal tumôr intal tiessût dal sen.
Chest al cjape dentri i fatôrs gjenetics, epigjenetics e ambientâi che a contribuissin al inizi, ae promozion e ae progression dal tumôr de sede.
Cualchi cambiament fisiopatologjic clâf intal tumôr di sen al inclût:
1. Mutazions gjenetichis: Mutazions in cualchi gjen, come il BRCA1 e il BRCA2, a puedin aumentâ il risi di svilupâ il cancar al sen.
Chestis mutazions a puedin jessi ereditaris o acuisidis vie pe vite di une persone.
2. squilibris ormonâi: i ormonis, soredut i estrogjens, a puedin vê un rûl intal svilup e cressite dal cancar de mame.
Un disecuilibri tai nivei dai ormonis o l'espozion a un ecès di estrogjen a puedin aumentâ il risi di vê il cancar al sen.
3. Infiammazion: la infiammazion croniche intal tiessût dal sen e pues contribuî al svilup dal cancar dal sen promovint la cressite e la sorevivence des celulis dal cancar.
4. Microambient dal tumôr: l'ambient ator dal tumôr, includint la matriç extracelulâr, lis celulis imunitariis e i vasi sanguins, al pues influençâ la cressite e la difusion dal tumôr.
5 - Metastasi: il cancar al pues cjapâ altris parts dal cuarp par mieç dal sisteme linfatic o dal flus dal sanc, puartant ae formazion di tumôrs secondaris in orghins lontans.
Capî la fisiopatologjie dal tumôr dal sen al è fondamentâl par svilupâ strategjiis di prevenzion, individuazion precoce e cure eficacis.
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Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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