How is Alzheimer diagnosed?

['Èist ris an duilleag seo']

Ciamar a thèid alzheimer a dhearbhadh?

Tha galar Alzheimer air a dhearbhadh tro mheasgachadh de dhòighean, a 'toirt a-steach measadh meidigeach mionaideach, deuchainnean inntinneil agus neuropsychological, ìomhaighean eanchainn, agus pròiseas cuir às do dh' adhbharan eile a dh 'fhaodadh a bhith ann.

1. Measadh meidigeach: Bidh dotair a 'dèanamh sgrùdadh corporra agus a' toirt eachdraidh mheidigeach mionaideach gus cuir às do dh 'adhbharan eile a dh' fhaodadh a bhith ann airson call cuimhne no crìonadh inntinneil, leithid duilgheadasan thyroid, easbhaidhean vitimín, no tumors eanchainn.

2. Deuchainnean inntinneil agus neuropsychological: Bidh na deuchainnean sin a'measadh cuimhne, cànan, fuasgladh dhuilgheadasan, agus gnìomhan inntinneil eile gus ìre lagachadh inntinneil a dhearbhadh agus eadar-dhealachadh a dhèanamh eadar call cuimhne àbhaisteach co-cheangailte ri aois agus dementia.

3. Dealbhan eanchainn: Faodaidh dealbhan ath-bhualadh magnetach (MRI) no tomography coimpiutair (CT) sganaidhean cuideachadh le bhith a 'comharrachadh atharrachaidhean structarail san eanchainn a dh' fhaodadh a bhith a 'nochdadh galar Alzheimer.

Faodar sganaidhean tomography sgaoilidh positron (PET) a chleachdadh cuideachd gus ìrean de phròtainean sònraichte co-cheangailte ri galar Alzheimer a thomhas.

4. Deuchainnean fala: Tha rannsachadh o chionn ghoirid air sealltainn gum faod cuid de dheuchainnean fala cuideachadh le bhith a 'lorg galar Alzheimer le bhith a' tomhas ìrean de phròtainean sònraichte no biomarkers co-cheangailte ris a 'ghalair.

5. Pròiseas cuir às: Leis nach eil aon deuchainn deimhinnte ann airson galar Alzheimer, bidh breithneachadh gu tric a 'toirt a-steach a bhith a' cuir às do dh 'adhbharan eile a dh' fhaodadh a bhith ann airson comharraidhean coltach ri dementia.

Tha e cudromach a thoirt fa-near nach urrainnear breithneachadh deimhinnte air galar Alzheimer a dhèanamh ach às deidh bàs tro sgrùdadh air clò eanchainn.

Ach, tha na dòighean breithneachaidh a th' ann an-dràsta a' toirt ìre àrd de chinnt airson breithneachadh clionaigeach fhad's a tha an neach fhathast beò.

Tha breithneachadh tràth cudromach airson làimhseachadh a thòiseachadh agus planadh airson an ama ri teachd.

['Tagraidhean']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

['Àicheadh: meidigeach']

["Tha an làrach-lìn seo air a thoirt seachad airson adhbharan foghlaim agus fiosrachaidh a-mhàin agus chan eil e a' toirt seachad comhairle mheidigeach no seirbheisean proifeiseanta."]

["Cha bu chòir am fiosrachadh a chaidh a thoirt seachad a chleachdadh airson duilgheadas slàinte no galar a dhearbhadh no a làimhseachadh, agus bu chòir dhaibhsan a tha a'sireadh comhairle meidigeach pearsanta co-chomhairle a chumail ri lighiche-sprèidh."]

["Thoiribh fa-near gu bheil an lìon neural a tha a' cruthachadh fhreagairtean do na ceistean, gu sònraichte neo-chruinneasach nuair a thig e gu susbaint àireamhach. Mar eisimpleir, an àireamh de dhaoine a chaidh a dhearbhadh le galar sònraichte."]

["Faigh comhairle an dotair agad no solaraiche slàinte eile a tha airidh air comhairle a thaobh tinneas meidigeach. Na dì-meas comhairle meidigeach proifeiseanta no dàil ann a bhith ga shireadh air sgàth rudeigin a leugh thu air an làrach-lìn seo. Ma tha thu a'smaoineachadh gum faodadh èiginn meidigeach a bhith agad, cuir fòn gu 911 no rachaibh chun t-seòmar èiginn as fhaisge sa bhad. Chan eil dàimh dotair-euslainteach air a chruthachadh leis an làrach-lìn seo no a chleachdadh. Chan eil BioMedLib no a luchd-obrach, no neach sam bith a tha a' cur ris an làrach-lìn seo, a 'dèanamh riochdachaidhean sam bith, fosgailte no a' toirt a-steach, a thaobh an fhiosrachaidh a tha air a thoirt seachad an seo no a chleachdadh."]

['Àicheadh: còraichean']

["Tha Achd Dlighe-sgrìobhaidh na Mìle Bliadhna Didseatach 1998, 17 U.S.C. § 512 (an DMCA) a' toirt ath-chuinge do shealbhadairean dlighe-sgrìobhaidh a tha den bheachd gu bheil stuth a tha a' nochdadh air an eadar-lìon a' briseadh an còraichean fo lagh dlighe-sgrìobhaidh na SA. "]

["Ma tha thu a' creidsinn ann an deagh chreideamh gu bheil susbaint no stuth sam bith a tha ri fhaotainn a thaobh ar làrach-lìn no ar seirbheisean a' briseadh d' dlighe-sgrìobhaidh, faodaidh tu fhèin (no an riochdaire agad) fios a chur thugainn ag iarraidh gun tèid an susbaint no an stuth a thoirt air falbh, no gun tèid cothrom a chur air. "]

["Feumar sanasan a chur ann an sgrìobhadh tro phost-d (faic an roinn 'Contact' airson seòladh puist-d). "]

["Tha an DMCA ag iarraidh gum bi am fiosrachadh a leanas anns an fhios agad mu bhriseadh còraichean-sgrìobhaidh a thathar ag ràdh: (1) tuairisgeul air an obair fo chòraichean-sgrìobhaidh a tha fo chasaid briseadh; (2) tuairisgeul air an t-susbaint a thathar ag ràdh a tha a 'briseadh agus fiosrachadh gu leòr gus leigeil leinn an t-susbaint a lorg; (3) fiosrachadh conaltraidh dhut, a' toirt a-steach do sheòladh, àireamh fòn agus seòladh puist-d; (4) aithris bhuat gu bheil creideas math agad nach eil an t-susbaint san dòigh a tha gearan air a cheadachadh le sealbhadair a 'chòraichean-sgrìobhaidh, no an neach-ionaid aige, no le gnìomh lagha sam bith; "]

['(5) Dearbhadh agaibh, air a shoidhnigeadh fo pheanas mionnachaidh, gu bheil am fiosrachadh san fhiosrachadh ceart agus gu bheil ùghdarras agaibh na còraichean-sgrìobhaidh a thathar ag ràdh a chaidh a bhriseadh a chur an gnìomh; ']

['agus (6) ainm-sgrìobhte corporra no eileagtronaigeach an t-sealbhadair dlighe-sgrìobhaidh no neach a tha ùghdarraichte a bhith ag obair às leth an t-sealbhadair dlighe-sgrìobhaidh. ']

["Ma dh'fhailicheas tu air a' ghearan agad a dheasachadh, faodaidh e dàil a chur air mura cuir thu a-steach am fiosrachadh gu lèir gu h-àrd."]

['Cuir fios thugainn']

['Cuir post-d thugainn le ceist / moladh sam bith.']

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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['Mu dheidhinn']

["Bidh BioMedLib a' cleachdadh choimpiutairean fèin-ghluasadach (algorithms ionnsachaidh innealan) gus paidhrichean ceist is freagairt a chruthachadh."]

["Bidh sinn a' tòiseachadh le 35 millean foillseachadh bith-leigheis de PubMed/Medline. Cuideachd, duilleagan-lìn de RefinedWeb."]

['Faic "References" cuideachd "Disclaimer".']