Is riocht craiceann é urticaria, ar a dtugtar hives go coitianta, a bhfuil cuma itchy, ardaithe, welts dearga (wheals) ar an gcraiceann ann.
Baineann pathophysiology urticaria le scaoileadh histamine agus idirghabhálaithe athlastacha eile ó chealla mast, atá ina chealla imdhíonachta a fhaightear sa chraiceann agus i fíocháin eile.
I urticaria géar, déantar scaoileadh histamine agus idirghabhálaithe eile a spreagadh ag imoibriú ailléirgeach ar ailléirgeach ar leith, mar shampla bia, cógais, nó sting feithidí.
Mar thoradh air seo déantar na cealla mast a degranulate, ag scaoileadh histamine agus idirghabhálaithe eile a chuireann cosc ar soithigh fola a bheith leaky, rud a fhágann go gcruthófar wheals.
I urticaria ainsealach, is minic nach bhfuil an chúis ar eolas, ach meastar go bhfuil baint aige le meicníocht autoimmune.
Sa chás seo, táirgeann an corp autoantibodies a dhíríonn ar an nglacadóir IgE ard-affinity (FcεRI) ar mast cells, rud a fhágann go bhfuil siad gníomhach agus go scaoileann siad histamine agus idirghabhálaithe eile.
I urticaria géar agus ainsealach araon, tugann scaoileadh histamine agus idirghabhálaithe eile na hairíonna tréitheacha de itching, deargadh, agus swelling.
Is gnách go mbaineann an cóireáil le húsáid frith-histamínigh chun éifeachtaí histamine a bhac agus na hairíonna a laghdú.
I gcásanna tromchúiseacha, d'fhéadfaí cógais eile mar corticosteroids nó omalizumab a úsáid chun an riocht a rialú.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
Diúltú freagrachta: leighis
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Cumarsáid
Seol ríomhphost dúinn le haon cheist / moladh le do thoil.
What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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