What is prognosis of Alzheimer?

Kakva je prognoza za Alzheimerovu bolest?

Prognoza Alzheimerove bolesti je općenito loša, jer je to progresivno i degenerativno stanje za koje nema poznatog lijeka.

Brzina progresije varira od osobe do osobe, ali bolest se obično s vremenom pogoršava, što dovodi do smanjenja kognitivnih i fizičkih sposobnosti.

Kako bolest napreduje, pojedinci mogu doživjeti gubitak pamćenja, poteškoće u govoru i komunikaciji, dezorijentaciju i promjene raspoloženja i ponašanja.

S vremenom se možda neće moći brinuti za sebe i trebat će im punovremena pomoć.

Prosječni očekivani životni vijek nakon dijagnoze je oko 8-10 godina, ali to može znatno varirati ovisno o dobi pojedinca, općem zdravlju i drugim čimbenicima.

Iako ne postoji lijek, tretmani i terapije mogu pomoći u upravljanju simptomima i poboljšanju kvalitete života osoba s Alzheimerovom bolešću.

Referencije

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Kaldjian LC: Survival versus prognosis in Alzheimer disease. Ann Intern Med. 2004, 141 (7): 575; author reply 575.

Mayeux R, Stern Y, Sano M: Heterogeneity and prognosis in dementia of the Alzheimer type. Bull Clin Neurosci. 1985, 50 (): 7-10.

DeKosky ST, Golde T: Cerebrospinal Biomarkers in Alzheimer Disease-Potential Roles as Markers of Prognosis and Neuroplasticity. JAMA Neurol. 2016, 73 (5): 508-10.

Yaffe K: Treatment of Alzheimer disease and prognosis of dementia: time to translate research to results. JAMA. 2010, 304 (17): 1952-3.

Zhu B, Chen X, Li W, Zhou D: Effect of Alzheimer Disease on Prognosis of Intensive Care Unit (ICU) Patients: A Propensity Score Matching Analysis. Med Sci Monit. 2022, 28 (): e935397.

Malpetti M, Joie R, Rabinovici GD: Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials. J Nucl Med. 2022, 63 (6): 830-832.

Schaeffer EL, Figueiro M, Gattaz WF: Insights into Alzheimer disease pathogenesis from studies in transgenic animal models. Clinics (Sao Paulo). 2011, 66 Suppl 1 (): 45-54.

Bhagwat N, Pipitone J, Voineskos AN, Chakravarty MM: An artificial neural network model for clinical score prediction in Alzheimer disease using structural neuroimaging measures J Psychiatry Neurosci. 2019, 44 (4): 246-260.

Vermunt L, van Paasen AJL, Teunissen CE, Scheltens P, Visser PJ, Tijms BM: Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal. Neurology. 2019, 92 (23): e2699-e2705.

Raji MA, Brady SR: Mirtazapine for treatment of depression and comorbidities in Alzheimer disease. Ann Pharmacother. 2001, 35 (9): 1024-7.

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What is prognosis of alzheimer?

The prognosis of Alzheimer's disease is generally poor, as it is a progressive and degenerative condition with no known cure.

The rate of progression varies from person to person, but the disease typically worsens over time, leading to a decline in cognitive and physical abilities.

As the disease progresses, individuals may experience memory loss, difficulty with language and communication, disorientation, and changes in mood and behavior.

Eventually, they may become unable to care for themselves and require full-time assistance.

The average life expectancy after diagnosis is around 8-10 years, but this can vary widely depending on the individual's age, overall health, and other factors.

While there is no cure, treatments and therapies can help manage symptoms and improve quality of life for those with Alzheimer's disease.

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